mppA:Gene Product(s)

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Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

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Standard name

MppA

Synonyms

murein tripeptide (L-ala-gamma-D-glutamyl-meso-DAP) transporter subunit[1], periplasmic-binding component of ABC superfamily[1], B1329[2][1], YnaH[2][1], MppA[2][1] , ECK1326, JW1322, ynaH, b1329

Product description

periplasmic murein tripeptide binding protein[2][3];

Component of Murein Tripeptide ABC Transporter[3]

Murein tripeptide/heme transport, periplasmic binding protein; L-ala-gamma-D-glutamyl-meso-DAP binding protein; feeds into the Dpp (heme)and Opp (murein peptide) transport systems[4]

EC number (for enzymes)


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Notes

Function

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<protect> Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0005215

transporter activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000914

F

Seeded from EcoCyc (v14.0)

complete

GO:0042939

tripeptide transport

PMID:9495761[5]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0015031

protein transport

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0653

P

Seeded from EcoCyc (v14.0)

complete

GO:0042597

periplasmic space

PMID:9495761[5]

IDA: Inferred from Direct Assay

C

complete

GO:0042597

periplasmic space

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0574

C

Seeded from EcoCyc (v14.0)

complete

GO:0042597

periplasmic space

GO_REF:0000023

IEA: Inferred from Electronic Annotation

SP_SL:SL-0200

C

Seeded from EcoCyc (v14.0)

complete

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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type Partner Notes References Evidence

Protein

Subunits of Murein Tripeptide ABC Transporter

could be indirect


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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment Description Evidence Reference/Source Notes

periplasm

Periplasm

PMID:9495761[5]

EchoLocation:mppA


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Notes

Structure and Physical Properties

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<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence

at EcoCyc 

MSVRGKLMKH SVSVTCCALL VSSISLSYAA EVPSGTVLAE KQELVRHIKD EPASLDPAKA
VGLPEIQVIR DLFEGLVNQN EKGEIVPGVA TQWKSNDNRI WTFTLRDNAK WADGTPVTAQ
DFVYSWQRLV DPKTLSPFAW FAALAGINNA QAIIDGKATP DQLGVTAVDA HTLKIQLDKP
LPWFVNLTAN FAFFPVQKAN VESGKEWTKP GNLIGNGAYV LKERVVNEKL VVVPNTHYWD
NAKTVLQKVT FLPINQESAA TKRYLAGDID ITESFPKNMY QKLLKDIPGQ VYTPPQLGTY
YYAFNTQKGP TADQRVRLAL SMTIDRRLMT EKVLGTGEKP AWHFTPDVTA GFTPEPSPFE
QMSQEELNAQ AKTLLSAAGY GPQKPLKLTL LYNTSENHQK IAIAVASMWK KNLGVDVKLQ
NQEWKTYIDS RNTGNFDVIR ASWVGDYNEP STFLTLLTST HSGNISRFNN PAYDKVLAQA
STENTVKARN ADYNAAEKIL MEQAPIAPIY QYTNGRLIKP WLKGYPINNP EDVAYSRTMY IVKH
Length

544

Mol. Wt

60.672 kDa

pI

9.1 (calculated)

Extinction coefficient

102,790 - 103,040 (calc based on 21 Y, 13 W, and 2 C residues)

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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type Residues Description Notes References

motif

1-22

UniProt Manual:Signal Peptides

UniProt:P77348

Domain

77..457

PF00496 Bacterial extracellular solute-binding proteins, family 5 Middle

PMID:19920124[6]

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Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=mppA taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

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Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type Source Notes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

NCBI (Protein) (EcoliWiki Page)

GI:90111250

Escherichia coli str. K-12 substr. MG1655

NCBI (Protein) (EcoliWiki Page)

GeneID:945951

Escherichia coli str. K-12 substr. MG1655

ASAP

ASAP:ABE-0004460

Escherichia coli str. K-12 substr. MG1655

UniProt (EcoliWiki Page)

UniProtKB/Swiss-Prot:P77348

Escherichia coli str. K-12 substr. MG1655

EcoCyc

EcoCyc:G6665

Escherichia coli str. K-12 substr. MG1655

EcoGene

EcoGene:EG13376

Escherichia coli str. K-12 substr. MG1655

NCBI (Gene) (EcoliWiki Page)

GeneID:945951

Escherichia coli str. K-12 substr. MG1655

RegulonDB

RegulonDB:ECK120003260

Escherichia coli str. K-12 substr. MG1655

EchoBASE

EchoBASE:EB3158

Escherichia coli str. K-12 substr. MG1655

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Notes

Links

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References

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See Help:References for how to manage references in EcoliWiki.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ 3.0 3.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  5. ↑ 5.0 5.1 5.2 Park, JT et al. (1998) MppA, a periplasmic binding protein essential for import of the bacterial cell wall peptide L-alanyl-gamma-D-glutamyl-meso-diaminopimelate. J. Bacteriol. 180 1215-23 PubMed
  6. ↑ Finn, RD et al. (2010) The Pfam protein families database. Nucleic Acids Res. 38 D211-22 PubMed

Categories

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