mntH:Gene Product(s)

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Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

MntH

Synonyms

manganese/divalent cation transporter[1], B2392[2][1], MntA[2][1], MntH[2][1], YfeP[2][1] , ECK2387, JW2388, mntA, yfeP, b2392

Product description

MntH manganese ion transporter[2][3]

Mn(2+) transporter, role in bacterial response to reactive oxygen species; also transports Fe(2+), Cd(2+) and other divalent metals[4]

EC number (for enzymes)


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Notes

Function

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<protect> Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0015292

uniporter activity

PMID:10712688[5]

IMP: Inferred from Mutant Phenotype

F

complete

GO:0015684

ferrous iron transport

PMID:10712688[5]

IMP: Inferred from Mutant Phenotype

P

preference for Mn(II)

complete

GO:0030001

metal ion transport

PMID:10712688[5]

IMP: Inferred from Mutant Phenotype

P

Mn(II) and Fe (II)

complete

GO:0005215

transporter activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001046

F

Seeded from EcoCyc (v14.0)

complete

GO:0005886

plasma membrane

GOA:hamap
GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_00221

C

Seeded from EcoCyc (v14.0)

complete

GO:0005886

plasma membrane

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0997

C

Seeded from EcoCyc (v14.0)

complete

GO:0005886

plasma membrane

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-1003

C

Seeded from EcoCyc (v14.0)

complete

GO:0006828

manganese ion transport

GOA:hamap
GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_00221

P

Seeded from EcoCyc (v14.0)

complete

GO:0015293

symporter activity

GOA:hamap
GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_00221

F

Seeded from EcoCyc (v14.0)

complete

GO:0015293

symporter activity

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0769

F

Seeded from EcoCyc (v14.0)

complete

GO:0005886

plasma membrane

PMID:14607838[6]

IDA: Inferred from Direct Assay

C

complete

GO:0016021

integral to membrane

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0812

C

Seeded from EcoCyc (v14.0)

complete

GO:0016021

integral to membrane

PMID:14607838[6]

IMP: Inferred from Mutant Phenotype

C

complete

GO:0016021

integral to membrane

GO_REF:0000023

IEA: Inferred from Electronic Annotation

SP_SL:SL-9909

C

Seeded from EcoCyc (v14.0)

complete

GO:0030001

metal ion transport

PMID:14607838[6]

IMP: Inferred from Mutant Phenotype

P

Cd(II)

complete

GO:0030001

metal ion transport

PMID:10712688[5]

IMP: Inferred from Mutant Phenotype

P

Seeded from EcoCyc (v14.0)

complete

GO:0030001

metal ion transport

PMID:14607838[6]

IMP: Inferred from Mutant Phenotype

P

Seeded from EcoCyc (v14.0)

complete

GO:0015293

symporter activity

PMID:18227061[7]

IDA: Inferred from Direct Assay

F

complete

GO:0030145

manganese ion binding

GOA:hamap
GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_00221

F

Seeded from EcoCyc (v14.0)

complete

GO:0006824

cobalt ion transport

PMID:15641799[8]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0030145

manganese ion binding

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0464

F

Seeded from EcoCyc (v14.0)

complete

GO:0015691

cadmium ion transport

PMID:18227061[7]

IDA: Inferred from Direct Assay

P

complete

GO:0006826

iron ion transport

PMID:15641799[8]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0006828

manganese ion transport

PMID:15641799[8]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0015691

cadmium ion transport

PMID:15641799[8]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0015078

hydrogen ion transmembrane transporter activity

PMID:15641799[8]

IMP: Inferred from Mutant Phenotype

F

complete

GO:0005384

manganese ion transmembrane transporter activity

PMID:15641799[8]

IMP: Inferred from Mutant Phenotype

F

complete

GO:0015086

cadmium ion transmembrane transporter activity

PMID:15641799[8]

IMP: Inferred from Mutant Phenotype

F

complete

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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type Partner Notes References Evidence
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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment Description Evidence Reference/Source Notes

plasma membrane

C-terminus localized to the periplasm with 11 predicted transmembrane domains

Daley et al. (2005) [9]

plasma membrane

From EcoCyc[3]


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Notes

Structure and Physical Properties

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<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence

at EcoCyc 

MTNYRVESSS GRAARKMRLA LMGPAFIAAI GYIDPGNFAT NIQAGASFGY QLLWVVVWAN
LMAMLIQILS AKLGIATGKN LAEQIRDHYP RPVVWFYWVQ AEIIAMATDL AEFIGAAIGF
KLILGVSLLQ GAVLTGIATF LILMLQRRGQ KPLEKVIGGL LLFVAAAYIV ELIFSQPNLA
QLGKGMVIPS LPTSEAVFLA AGVLGATIMP HVIYLHSSLT QHLHGGSRQQ RYSATKWDVA
IAMTIAGFVN LAMMATAAAA FHFSGHTGVA DLDEAYLTLQ PLLSHAAATV FGLSLVAAGL
SSTVVGTLAG QVVMQGFIRF HIPLWVRRTV TMLPSFIVIL MGLDPTRILV MSQVLLSFGI
ALALVPLLIF TSDSKLMGDL VNSKRVKQTG WVIVVLVVAL NIWLLVGTAL GL
Length

412

Mol. Wt

44.194 kDa

pI

10.2 (calculated)

Extinction coefficient

57,410 (calc based on 9 Y, 8 W, and 0 C residues)

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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type Residues Description Notes References

Domain

38..384

PF01566 Natural resistance-associated macrophage protein

PMID:19920124[10]

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<motif_map/>

tmhmm.php?gene=mntH&show=pic&.jpg
Click the image to view raw output from TMHMM.

Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=mntH taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

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Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type Source Notes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

NCBI (Protein) (EcoliWiki Page)

GI:16130324

Escherichia coli str. K-12 substr. MG1655

NCBI (Protein) (EcoliWiki Page)

GeneID:946899

Escherichia coli str. K-12 substr. MG1655

ASAP

ASAP:ABE-0007889

Escherichia coli str. K-12 substr. MG1655

UniProt (EcoliWiki Page)

UniProtKB/Swiss-Prot:P0A769

Escherichia coli str. K-12 substr. MG1655

EcoCyc

EcoCyc:G7254

Escherichia coli str. K-12 substr. MG1655

EcoGene

EcoGene:EG14157

Escherichia coli str. K-12 substr. MG1655

NCBI (Gene) (EcoliWiki Page)

GeneID:946899

Escherichia coli str. K-12 substr. MG1655

RegulonDB

RegulonDB:ECK120003828

Escherichia coli str. K-12 substr. MG1655

EchoBASE

EchoBASE:EB3909

Escherichia coli str. K-12 substr. MG1655

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Notes

Links

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References

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See Help:References for how to manage references in EcoliWiki.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 2.4 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ 3.0 3.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  5. ↑ 5.0 5.1 5.2 5.3 Makui, H et al. (2000) Identification of the Escherichia coli K-12 Nramp orthologue (MntH) as a selective divalent metal ion transporter. Mol. Microbiol. 35 1065-78 PubMed
  6. ↑ 6.0 6.1 6.2 6.3 Courville, P et al. (2004) Determination of transmembrane topology of the Escherichia coli natural resistance-associated macrophage protein (Nramp) ortholog. J. Biol. Chem. 279 3318-26 PubMed
  7. ↑ 7.0 7.1 Courville, P et al. (2008) Solute carrier 11 cation symport requires distinct residues in transmembrane helices 1 and 6. J. Biol. Chem. 283 9651-8 PubMed
  8. ↑ 8.0 8.1 8.2 8.3 8.4 8.5 8.6 Chaloupka, R et al. (2005) Identification of functional amino acids in the Nramp family by a combination of evolutionary analysis and biophysical studies of metal and proton cotransport in vivo. Biochemistry 44 726-33 PubMed
  9. ↑ Daley, DO et al. (2005) Global topology analysis of the Escherichia coli inner membrane proteome. Science 308 1321-3 PubMed
  10. ↑ Finn, RD et al. (2010) The Pfam protein families database. Nucleic Acids Res. 38 D211-22 PubMed

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