mngR:Gene Product(s)

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Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

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Standard name

MngR

Synonyms

DNA-binding transcriptional dual regulator, fatty-acyl-binding[1], B0730[2][1], YbgB[2][1], transcriptional regulator of succinylCoA synthetase operon[2][1], fatty acyl responsive regulator[2][1], P30[2][1], FarR[2][1] , ECK0718, farR, JW0719, ybgB, b0730

Product description

MngR[2][3];

Component of MngR transcriptional repressor[2][3]; MngR-acyl-CoA[2][3]

mngAB operon repressor, mannosyl glycerate utilization[4]

EC number (for enzymes)


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Notes

Function

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<protect> Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0003700

transcription factor activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000524

F

Seeded from EcoCyc (v14.0)

complete

GO:0003700

transcription factor activity

PMID:12757941[5]

ISS: Inferred from Sequence or Structural Similarity

Swiss-Prot:P26602
Swiss-Prot:P39796
Swiss-Prot:B7V3J8

F

Seeded from EcoCyc (v14.0)

complete

GO:0003700

transcription factor activity

PMID:14645248[6]

IDA: Inferred from Direct Assay

F

Seeded from EcoCyc (v14.0)

complete

GO:0003700

transcription factor activity

PMID:7805834[7]

IDA: Inferred from Direct Assay

F

Seeded from EcoCyc (v14.0)

complete

GO:0005622

intracellular

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000524

C

Seeded from EcoCyc (v14.0)

complete

GO:0016566

specific transcriptional repressor activity

PMID:12757941[5]

ISS: Inferred from Sequence or Structural Similarity

Swiss-Prot:P26602
Swiss-Prot:P39796
Swiss-Prot:B7V3J8

F

Seeded from EcoCyc (v14.0)

complete

GO:0016566

specific transcriptional repressor activity

PMID:14645248[6]

IDA: Inferred from Direct Assay

F

Seeded from EcoCyc (v14.0)

complete

GO:0016566

specific transcriptional repressor activity

PMID:7805834[7]

IDA: Inferred from Direct Assay

F

Seeded from EcoCyc (v14.0)

complete

GO:0032582

negative regulation of gene-specific transcription

PMID:12757941[5]

ISS: Inferred from Sequence or Structural Similarity

Swiss-Prot:P26602
Swiss-Prot:P39796
Swiss-Prot:B7V3J8

P

Seeded from EcoCyc (v14.0)

complete

GO:0032582

negative regulation of gene-specific transcription

PMID:14645248[6]

IDA: Inferred from Direct Assay

P

Seeded from EcoCyc (v14.0)

complete

GO:0032582

negative regulation of gene-specific transcription

PMID:7805834[7]

IDA: Inferred from Direct Assay

P

Seeded from EcoCyc (v14.0)

complete

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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type Partner Notes References Evidence

Protein

Subunits of MngR transcriptional repressor

could be indirect

Protein

rpmF

PMID:16606699[8]

Experiment(s):EBI-1137834

Protein

prs

PMID:16606699[8]

Experiment(s):EBI-1137834

Protein

rpmB

PMID:16606699[8]

Experiment(s):EBI-1137834

Protein

rmlA2

PMID:16606699[8]

Experiment(s):EBI-1137834

Protein

Subunits of MngR-acyl-CoA

could be indirect


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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment Description Evidence Reference/Source Notes
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Notes

Structure and Physical Properties

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<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence

at EcoCyc 

MGHKPLYRQI ADRIREQIAR GELKPGDALP TESALQTEFG VSRVTVRQAL RQLVEQQILE
SIQGSGTYVK EERVNYDIFQ LTSFDEKLSD RHVDTHSEVL IFEVIPADDF LQQQLQITPQ
DRVWHVKRVR YRKQKPMALE ETWMPLALFP DLTWQVMENS KYHFIEEVKK MVIDRSEQEI
IPLMPTEEMS RLLNISQTKP ILEKVSRGYL VDGRVFEYSR NAFNTDDYKF TLIAQRKSSR
Length

240

Mol. Wt

28.273 kDa

pI

6.7 (calculated)

Extinction coefficient

28,420 (calc based on 8 Y, 3 W, and 0 C residues)

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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type Residues Description Notes References

Domain

6..69

PF00392 Bacterial regulatory proteins, gntR family

PMID:19920124[9]

Domain

90..229

PF07702 UTRA domain

PMID:19920124[9]

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Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=mngR taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

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Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type Source Notes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

NCBI (Protein) (EcoliWiki Page)

GI:16128705

Escherichia coli str. K-12 substr. MG1655

NCBI (Protein) (EcoliWiki Page)

GeneID:945371

Escherichia coli str. K-12 substr. MG1655

ASAP

ASAP:ABE-0002487

Escherichia coli str. K-12 substr. MG1655

UniProt (EcoliWiki Page)

UniProtKB/Swiss-Prot:P13669

Escherichia coli str. K-12 substr. MG1655

EcoCyc

EcoCyc:EG11109

Escherichia coli str. K-12 substr. MG1655

EcoGene

EcoGene:EG11109

Escherichia coli str. K-12 substr. MG1655

NCBI (Gene) (EcoliWiki Page)

GeneID:945371

Escherichia coli str. K-12 substr. MG1655

RegulonDB

RegulonDB:ECK120001095

Escherichia coli str. K-12 substr. MG1655

EchoBASE

EchoBASE:EB1100

Escherichia coli str. K-12 substr. MG1655

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Notes

Links

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References

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See Help:References for how to manage references in EcoliWiki.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 2.8 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ 3.0 3.1 3.2 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  5. ↑ 5.0 5.1 5.2 Aravind, L & Anantharaman, V (2003) HutC/FarR-like bacterial transcription factors of the GntR family contain a small molecule-binding domain of the chorismate lyase fold. FEMS Microbiol. Lett. 222 17-23 PubMed
  6. ↑ 6.0 6.1 6.2 Sampaio, MM et al. (2004) Phosphotransferase-mediated transport of the osmolyte 2-O-alpha-mannosyl-D-glycerate in Escherichia coli occurs by the product of the mngA (hrsA) gene and is regulated by the mngR (farR) gene product acting as repressor. J. Biol. Chem. 279 5537-48 PubMed
  7. ↑ 7.0 7.1 7.2 Quail, MA et al. (1994) Identification of a fatty acyl responsive regulator (FarR) in Escherichia coli. FEBS Lett. 356 183-7 PubMed
  8. ↑ 8.0 8.1 8.2 8.3 Arifuzzaman, M et al. (2006) Large-scale identification of protein-protein interaction of Escherichia coli K-12. Genome Res. 16 686-91 PubMed
  9. ↑ 9.0 9.1 Finn, RD et al. (2010) The Pfam protein families database. Nucleic Acids Res. 38 D211-22 PubMed

Categories

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