minC:Gene Product(s)

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Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

MinC

Synonyms

cell division inhibitor[1], B1176[2][1], MinB[2][1], MinC[2][1] , ECK1164, JW1165, minB, b1176

Product description

cell division inhibitor of the MinC-MinD-MinE and DicB-MinC systems that regulate septum placement[2][3]

Inhibition of FtsZ ring polymerization; forms membrane-associated coiled arrays, more concentrated at the poles[4]

EC number (for enzymes)


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Notes

Function

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<protect> Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000917

barrier septum formation

GOA:hamap
GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_00267

P

Seeded from EcoCyc (v14.0)

complete

GO:0000917

barrier septum formation

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR013033

P

Seeded from EcoCyc (v14.0)

complete

GO:0000917

barrier septum formation

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0717

P

Seeded from EcoCyc (v14.0)

complete

GO:0007049

cell cycle

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0131

P

Seeded from EcoCyc (v14.0)

complete

GO:0042127

regulation of cell proliferation

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR007874

P

Seeded from EcoCyc (v14.0)

complete

GO:0051301

cell division

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0132

P

Seeded from EcoCyc (v14.0)

complete

GO:0051726

regulation of cell cycle

GOA:hamap
GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_00267

P

Seeded from EcoCyc (v14.0)

complete

GO:0051726

regulation of cell cycle

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR013033

P

Seeded from EcoCyc (v14.0)

complete

GO:0051301

cell division

PMID:2137246[5]

EXP: Inferred from Experiment

P

complete

GO:0051302

regulation of cell division

PMID:2137246[5]

EXP: Inferred from Experiment

P

complete

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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type Partner Notes References Evidence

Protein

rplB

PMID:16606699[6]

Experiment(s):EBI-1139075

Protein

nuoE

PMID:16606699[6]

Experiment(s):EBI-1139075

Protein

smp

PMID:16606699[6]

Experiment(s):EBI-1139075

Protein

rpsB

PMID:16606699[6]

Experiment(s):EBI-1139075

Protein

slyD

PMID:16606699[6]

Experiment(s):EBI-1139075

Protein

rpsD

PMID:16606699[6]

Experiment(s):EBI-1139075

Protein

rpsC

PMID:16606699[6]

Experiment(s):EBI-1139075

Protein

yhjH

PMID:16606699[6]

Experiment(s):EBI-1139075

Protein

rplE

PMID:16606699[6]

Experiment(s):EBI-1139075

Protein

MinD

PMID:8752322[7]

2 hybrid screen

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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment Description Evidence Reference/Source Notes

plasma membrane

From EcoCyc[3]


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Notes

Structure and Physical Properties

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<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence

at EcoCyc 

MSNTPIELKG SSFTLSVVHL HEAEPKVIHQ ALEDKIAQAP AFLKHAPVVL NVSALEDPVN
WSAMHKAVSA TGLRVIGVSG CKDAQLKAEI EKMGLPILTE GKEKAPRPAP TPQAPAQNTT
PVTKTRLIDT PVRSGQRIYA PQCDLIVTSH VSAGAELIAD GNIHVYGMMR GRALAGASGD
RETQIFCTNL MAELVSIAGE YWLSDQIPAE FYGKAARLQL VENALTVQPL N
Length

231

Mol. Wt

24.775 kDa

pI

6.9 (calculated)

Extinction coefficient

16,960 - 17,335 (calc based on 4 Y, 2 W, and 3 C residues)

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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type Residues Description Notes References

Domain

125..230

PF03775 Septum formation inhibitor MinC, C-terminal domain

PMID:19920124[8]

Domain

1..104

PF05209 Septum formation inhibitor MinC, N-terminal domain

PMID:19920124[8]

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Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=minC taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

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Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type Source Notes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

NCBI (Protein) (EcoliWiki Page)

GI:16129139

Escherichia coli str. K-12 substr. MG1655

NCBI (Protein) (EcoliWiki Page)

GeneID:945744

Escherichia coli str. K-12 substr. MG1655

ASAP

ASAP:ABE-0003941

Escherichia coli str. K-12 substr. MG1655

UniProt (EcoliWiki Page)

UniProtKB/Swiss-Prot:P18196

Escherichia coli str. K-12 substr. MG1655

EcoCyc

EcoCyc:EG10596

Escherichia coli str. K-12 substr. MG1655

EcoGene

EcoGene:EG10596

Escherichia coli str. K-12 substr. MG1655

NCBI (Gene) (EcoliWiki Page)

GeneID:945744

Escherichia coli str. K-12 substr. MG1655

RegulonDB

RegulonDB:ECK120000589

Escherichia coli str. K-12 substr. MG1655

EchoBASE

EchoBASE:EB0591

Escherichia coli str. K-12 substr. MG1655

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Notes

Links

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References

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See Help:References for how to manage references in EcoliWiki.

  1. ↑ 1.0 1.1 1.2 1.3 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ 3.0 3.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  5. ↑ 5.0 5.1 de Boer, PA et al. (1990) Central role for the Escherichia coli minC gene product in two different cell division-inhibition systems. Proc. Natl. Acad. Sci. U.S.A. 87 1129-33 PubMed
  6. ↑ 6.0 6.1 6.2 6.3 6.4 6.5 6.6 6.7 6.8 Arifuzzaman, M et al. (2006) Large-scale identification of protein-protein interaction of Escherichia coli K-12. Genome Res. 16 686-91 PubMed
  7. ↑ Huang, J et al. (1996) Interaction between FtsZ and inhibitors of cell division. J. Bacteriol. 178 5080-5 PubMed
  8. ↑ 8.0 8.1 Finn, RD et al. (2010) The Pfam protein families database. Nucleic Acids Res. 38 D211-22 PubMed

Categories

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