menB:Gene Product(s)

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Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

MenB

Synonyms

dihydroxynaphthoic acid synthetase[1], B2262[2][1], MenB[2][1], DHNA synthetase[2][1], O-succinylbenzoyl-CoA 1,4-dihydroxy-2-naphthoate-lyase (cyclizing)[2][1] , ECK2256, JW2257, b2262

Product description

NAPHTHOATE-SYN[2][3]

1,4-Dihydroxy-2-naphthoate synthase; menaquinone biosynthesis[4]

EC number (for enzymes)

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Notes

Function

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<protect> Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0005737

cytoplasm

C

Seeded from Riley et al 2006 [1].

Missing: evidence, reference

GO:0008935

naphthoate synthase activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR010198

F

Seeded from EcoCyc (v14.0)

complete

GO:0008935

naphthoate synthase activity

GOA:spec
GO_REF:0000003

IEA: Inferred from Electronic Annotation

EC:4.1.3.36

F

Seeded from EcoCyc (v14.0)

complete

GO:0009234

menaquinone biosynthetic process

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR010198

P

Seeded from EcoCyc (v14.0)

complete

GO:0009234

menaquinone biosynthetic process

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0474

P

Seeded from EcoCyc (v14.0)

complete

GO:0008935

naphthoate synthase activity

PMID:1629162[5]

IDA: Inferred from Direct Assay

F

complete

Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type Partner Notes References Evidence

Protein

hldD

PMID:15690043[6]

Experiment(s):EBI-884495, EBI-891396

Protein

rpsN

PMID:15690043[6]

Experiment(s):EBI-891396

Protein

nadE

PMID:16606699[7]

Experiment(s):EBI-1142375

Protein

pepD

PMID:16606699[7]

Experiment(s):EBI-1142375

Protein

rpsN

PMID:19402753[8]

LCMS(ID Probability):99.6

Protein

rfaD

PMID:19402753[8]

LCMS(ID Probability):99.6 MALDI(Z-score):38.730315

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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment Description Evidence Reference/Source Notes

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Notes

Structure and Physical Properties

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<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence

at EcoCyc

MIYPDEAMLY APVEWHDCSE GFEDIRYEKS TDGIAKITIN RPQVRNAFRP LTVKEMIQAL
ADARYDDNIG VIILTGAGDK AFCSGGDQKV RGDYGGYKDD SGVHHLNVLD FQRQIRTCPK
PVVAMVAGYS IGGGHVLHMM CDLTIAADNA IFGQTGPKVG SFDGGWGASY MARIVGQKKA
REIWFLCRQY DAKQALDMGL VNTVVPLADL EKETVRWCRE MLQNSPMALR CLKAALNADC
DGQAGLQELA GNATMLFYMT EEGQEGRNAF NQKRQPDFSK FKRNP
Length

285

Mol. Wt

31.633 kDa

pI

6.4 (calculated)

Extinction coefficient

36,900 - 37,900 (calc based on 10 Y, 4 W, and 8 C residues)


Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type Residues Description Notes References

Domain

35..206

PF00378 Enoyl-CoA hydratase/isomerase family

PMID:19920124[9]

<motif_map/>

Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=menB taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

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Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type Source Notes/Reference

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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

NCBI (Protein) (EcoliWiki Page)

GI:16130197

Escherichia coli str. K-12 substr. MG1655

NCBI (Protein) (EcoliWiki Page)

GeneID:946747

Escherichia coli str. K-12 substr. MG1655

ASAP

ASAP:ABE-0007476

Escherichia coli str. K-12 substr. MG1655

UniProt (EcoliWiki Page)

UniProtKB/Swiss-Prot:P0ABU0

Escherichia coli str. K-12 substr. MG1655

EcoCyc

EcoCyc:EG11368

Escherichia coli str. K-12 substr. MG1655

EcoGene

EcoGene:EG11368

Escherichia coli str. K-12 substr. MG1655

NCBI (Gene) (EcoliWiki Page)

GeneID:946747

Escherichia coli str. K-12 substr. MG1655

RegulonDB

RegulonDB:ECK120001336

Escherichia coli str. K-12 substr. MG1655

EchoBASE

EchoBASE:EB1342

Escherichia coli str. K-12 substr. MG1655

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Notes

Links

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References

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See Help:References for how to manage references in EcoliWiki.

  1. 1.0 1.1 1.2 1.3 1.4 1.5 1.6 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. 2.0 2.1 2.2 2.3 2.4 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  5. Sharma, V et al. (1992) Menaquinone (vitamin K2) biosynthesis: nucleotide sequence and expression of the menB gene from Escherichia coli. J. Bacteriol. 174 5057-62 PubMed
  6. 6.0 6.1 Butland, G et al. (2005) Interaction network containing conserved and essential protein complexes in Escherichia coli. Nature 433 531-7 PubMed
  7. 7.0 7.1 Arifuzzaman, M et al. (2006) Large-scale identification of protein-protein interaction of Escherichia coli K-12. Genome Res. 16 686-91 PubMed
  8. 8.0 8.1 Hu, P et al. (2009) Global functional atlas of Escherichia coli encompassing previously uncharacterized proteins. PLoS Biol. 7 e96 PubMed
  9. Finn, RD et al. (2010) The Pfam protein families database. Nucleic Acids Res. 38 D211-22 PubMed

Categories

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