marC:Gene Product(s)

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Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

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Standard name

MarC

Synonyms

predicted transporter[1], YdeC[2][1], YdeB[2][1], MarC[2][1], B1529[2][1] , ECK1522, JW1522, ydeB, ydeC, b1529

Product description

inner membrane protein involved in multiple antibiotic resistance[2][3]

Inner membrane protein, function unknown; not involved in antibiotic resistance[4]

EC number (for enzymes)


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Notes

Function

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<protect> Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0005887

integral to plasma membrane

PMID:11867724[5]

IDA: Inferred from Direct Assay

C

complete

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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type Partner Notes References Evidence
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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment Description Evidence Reference/Source Notes

plasma membrane

C-terminus localized to the periplasm with 6 predicted transmembrane domains

Daley et al. (2005) [6]

plasma membrane

From EcoCyc[3]


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Notes

Structure and Physical Properties

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<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence

at EcoCyc 

MLDLFKAIGL GLVVLLPLAN PLTTVALFLG LAGNMNSAER NRQSLMASVY VFAIMMVAYY
AGQLVMDTFG ISIPGLRIAG GLIVAFIGFR MLFPQQKAID SPEAKSKSEE LEDEPSANIA
FVPLAMPSTA GPGTIAMIIS SASTVRQSST FADWVLMVAP PLIFFLVAVI LWGSLRSSGA
IMRLVGKGGI EAISRLMGFL LVCMGVQFII NGILEIIKTY H
Length

221

Mol. Wt

23.618 kDa

pI

8.2 (calculated)

Extinction coefficient

16,960 - 17,085 (calc based on 4 Y, 2 W, and 1 C residues)

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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type Residues Description Notes References

Domain

5..217

PF01914 MarC family integral membrane protein

PMID:19920124[7]

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tmhmm.php?gene=marC&show=pic&.jpg
Click the image to view raw output from TMHMM.

Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=marC taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

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Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type Source Notes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

NCBI (Protein) (EcoliWiki Page)

GI:16129488

Escherichia coli str. K-12 substr. MG1655

NCBI (Protein) (EcoliWiki Page)

GeneID:947132

Escherichia coli str. K-12 substr. MG1655

ASAP

ASAP:ABE-0005106

Escherichia coli str. K-12 substr. MG1655

UniProt (EcoliWiki Page)

UniProtKB/Swiss-Prot:P0AEY1

Escherichia coli str. K-12 substr. MG1655

EcoCyc

EcoCyc:EG11637

Escherichia coli str. K-12 substr. MG1655

EcoGene

EcoGene:EG11637

Escherichia coli str. K-12 substr. MG1655

NCBI (Gene) (EcoliWiki Page)

GeneID:947132

Escherichia coli str. K-12 substr. MG1655

RegulonDB

RegulonDB:ECK120001584

Escherichia coli str. K-12 substr. MG1655

EchoBASE

EchoBASE:EB1593

Escherichia coli str. K-12 substr. MG1655

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Notes

Links

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References

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See Help:References for how to manage references in EcoliWiki.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 2.4 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ 3.0 3.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  5. ↑ Drew, D et al. (2002) Rapid topology mapping of Escherichia coli inner-membrane proteins by prediction and PhoA/GFP fusion analysis. Proc. Natl. Acad. Sci. U.S.A. 99 2690-5 PubMed
  6. ↑ Daley, DO et al. (2005) Global topology analysis of the Escherichia coli inner membrane proteome. Science 308 1321-3 PubMed
  7. ↑ Finn, RD et al. (2010) The Pfam protein families database. Nucleic Acids Res. 38 D211-22 PubMed

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