manA:Gene Product(s)

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Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

ManA

Synonyms

mannose-6-phosphate isomerase[1], Pmi[2][1], B1613[2][1], ManA[2][1], phosphomannose isomerase[2][1], phosphohexoisomerase[2][1], phosphohexomutase[2][1], D-mannose-6-phosphate ketol-isomerase[2][1] , ECK1608, JW1605, pmi, b1613

Product description

Mannosephosphate isomerase[3]

EC number (for enzymes)
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Notes

Function

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<protect> Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0004476

mannose-6-phosphate isomerase activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001250

F

Seeded from EcoCyc (v14.0)

complete

GO:0004476

mannose-6-phosphate isomerase activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR016305

F

Seeded from EcoCyc (v14.0)

complete

GO:0004476

mannose-6-phosphate isomerase activity

GOA:spec
GO_REF:0000003

IEA: Inferred from Electronic Annotation

EC:5.3.1.8

F

Seeded from EcoCyc (v14.0)

complete

GO:0005737

cytoplasm

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0963

C

Seeded from EcoCyc (v14.0)

complete

GO:0005737

cytoplasm

GO_REF:0000023

IEA: Inferred from Electronic Annotation

SP_SL:SL-0086

C

Seeded from EcoCyc (v14.0)

complete

GO:0008270

zinc ion binding

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001250

F

Seeded from EcoCyc (v14.0)

complete

GO:0008270

zinc ion binding

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0862

F

Seeded from EcoCyc (v14.0)

complete

GO:0046872

metal ion binding

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0479

F

Seeded from EcoCyc (v14.0)

complete

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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type Partner Notes References Evidence

Protein

prs

PMID:16606699[4]

Experiment(s):EBI-1140263

Protein

zwf

PMID:16606699[4]

Experiment(s):EBI-1140263

Protein

malZ

PMID:16606699[4]

Experiment(s):EBI-1140263

Protein

bioC

PMID:16606699[4]

Experiment(s):EBI-1140263

Protein

nadE

PMID:16606699[4]

Experiment(s):EBI-1140263

Protein

mviN

PMID:16606699[4]

Experiment(s):EBI-1140263

Protein

hybA

PMID:16606699[4]

Experiment(s):EBI-1140263

Protein

rplB

PMID:16606699[4]

Experiment(s):EBI-1140263

Protein

aas

PMID:16606699[4]

Experiment(s):EBI-1140263

Protein

ykgF

PMID:16606699[4]

Experiment(s):EBI-1140263

Protein

ushA

PMID:16606699[4]

Experiment(s):EBI-1140263

Protein

yqjG

PMID:16606699[4]

Experiment(s):EBI-1140263

Protein

yidK

PMID:16606699[4]

Experiment(s):EBI-1140263

Protein

gltX

PMID:16606699[4]

Experiment(s):EBI-1140263

Protein

ygaF

PMID:16606699[4]

Experiment(s):EBI-1140263

Protein

ydfT

PMID:15690043[5]

Experiment(s):EBI-892424

Protein

minC

PMID:15690043[5]

Experiment(s):EBI-892424

Protein

ycbY

PMID:15690043[5]

Experiment(s):EBI-892424

Protein

rimN

PMID:15690043[5]

Experiment(s):EBI-892424

Protein

rlmL

PMID:19402753[6]

LCMS(ID Probability):99.0

Protein

rimN

PMID:19402753[6]

LCMS(ID Probability):99.0

Protein

quuQ

PMID:19402753[6]

LCMS(ID Probability):99.0

Protein

minC

PMID:19402753[6]

LCMS(ID Probability):99.0

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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment Description Evidence Reference/Source Notes

cytoplasm

From EcoCyc[7]


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Notes

Structure and Physical Properties

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<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence

at EcoCyc 

MQKLINSVQN YAWGSKTALT ELYGMENPSS QPMAELWMGA HPKSSSRVQN AAGDIVSLRD
VIESDKSTLL GEAVAKRFGE LPFLFKVLCA AQPLSIQVHP NKHNSEIGFA KENAAGIPMD
AAERNYKDPN HKPELVFALT PFLAMNAFRE FSEIVSLLQP VAGAHPAIAH FLQQPDAERL
SELFASLLNM QGEEKSRALA ILKSALDSQQ GEPWQTIRLI SEFYPEDSGL FSPLLLNVVK
LNPGEAMFLF AETPHAYLQG VALEVMANSD NVLRAGLTPK YIDIPELVAN VKFEAKPANQ
LLTQPVKQGA ELDFPIPVDD FAFSLHDLSD KETTISQQSA AILFCVEGDA TLWKGSQQLQ
LKPGESAFIA ANESPVTVKG HGRLARVYNK L
Length

391

Mol. Wt

42.85 kDa

pI

5.3 (calculated)

Extinction coefficient

32,430 - 32,680 (calc based on 7 Y, 4 W, and 2 C residues)

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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type Residues Description Notes References

Domain

1..357

PF01238 Phosphomannose isomerase type I

PMID:19920124[8]

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Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=manA taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

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Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type Source Notes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

NCBI (Protein) (EcoliWiki Page)

GI:49176125

Escherichia coli str. K-12 substr. MG1655

NCBI (Protein) (EcoliWiki Page)

GeneID:944840

Escherichia coli str. K-12 substr. MG1655

ASAP

ASAP:ABE-0005398

Escherichia coli str. K-12 substr. MG1655

UniProt (EcoliWiki Page)

UniProtKB/Swiss-Prot:P00946

Escherichia coli str. K-12 substr. MG1655

EcoCyc

EcoCyc:EG10566

Escherichia coli str. K-12 substr. MG1655

EcoGene

EcoGene:EG10566

Escherichia coli str. K-12 substr. MG1655

NCBI (Gene) (EcoliWiki Page)

GeneID:944840

Escherichia coli str. K-12 substr. MG1655

RegulonDB

RegulonDB:ECK120000559

Escherichia coli str. K-12 substr. MG1655

EchoBASE

EchoBASE:EB0561

Escherichia coli str. K-12 substr. MG1655

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Notes

Links

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References

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See Help:References for how to manage references in EcoliWiki.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  4. ↑ 4.00 4.01 4.02 4.03 4.04 4.05 4.06 4.07 4.08 4.09 4.10 4.11 4.12 4.13 4.14 Arifuzzaman, M et al. (2006) Large-scale identification of protein-protein interaction of Escherichia coli K-12. Genome Res. 16 686-91 PubMed
  5. ↑ 5.0 5.1 5.2 5.3 Butland, G et al. (2005) Interaction network containing conserved and essential protein complexes in Escherichia coli. Nature 433 531-7 PubMed
  6. ↑ 6.0 6.1 6.2 6.3 Hu, P et al. (2009) Global functional atlas of Escherichia coli encompassing previously uncharacterized proteins. PLoS Biol. 7 e96 PubMed
  7. ↑ EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  8. ↑ Finn, RD et al. (2010) The Pfam protein families database. Nucleic Acids Res. 38 D211-22 PubMed

Categories

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