macA:Gene Product(s)

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Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

MacA

Synonyms

macrolide transporter subunit, membrane fusion protein (MFP) component[1], B0878[2][1], YbjY[2][1], MacA[2][1] , ECK0869, JW0862, ybjY, b0878

Product description

MacA[2][3];

Component of MacAB macrolide efflux transporter complex[2]; MacAB-TolC Macrolide Efflux Transport System[3]

Membrane fusion protein (MFP) for macrolide efflux; subunit of ABC-type, TolC-dependent transporter MacAB; signal anchor; periplasmic[4]

EC number (for enzymes)


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Notes

Function

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<protect> Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0005886

plasma membrane

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0997

C

Seeded from EcoCyc (v14.0)

complete

GO:0005886

plasma membrane

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-1003

C

Seeded from EcoCyc (v14.0)

complete

GO:0006810

transport

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0813

P

Seeded from EcoCyc (v14.0)

complete

GO:0008565

protein transporter activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR006143

F

Seeded from EcoCyc (v14.0)

complete

GO:0009306

protein secretion

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR006143

P

Seeded from EcoCyc (v14.0)

complete

GO:0016020

membrane

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR006143

C

Seeded from EcoCyc (v14.0)

complete

GO:0019898

extrinsic to membrane

PMID:11544226[5]

IDA: Inferred from Direct Assay

C

complete

GO:0016020

membrane

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0472

C

Seeded from EcoCyc (v14.0)

complete

GO:0019898

extrinsic to membrane

GO_REF:0000023

IEA: Inferred from Electronic Annotation

SP_SL:SL-9903

C

Seeded from EcoCyc (v14.0)

complete

GO:0046677

response to antibiotic

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0046

P

Seeded from EcoCyc (v14.0)

complete

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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type Partner Notes References Evidence

Protein

Subunits of MacAB macrolide efflux transporter complex

could be indirect

Protein

rplV

PMID:16606699[6]

Experiment(s):EBI-1138239

Protein

rpmB

PMID:16606699[6]

Experiment(s):EBI-1138239

Protein

yibL

PMID:16606699[6]

Experiment(s):EBI-1138239

Protein

atpD

PMID:19402753[7]

MALDI(Z-score):22.953635

Protein

uidA

PMID:19402753[7]

LCMS(ID Probability):98.8

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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment Description Evidence Reference/Source Notes
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Notes

Structure and Physical Properties

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<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence

at EcoCyc 

MAYGVFRKFM KKRKTVKKRY VIALVIVIAG LITLWRILNA PVPTYQTLIV RPGDLQQSVL
ATGKLDALRK VDVGAQVSGQ LKTLSVAIGD KVKKDQLLGV IDPEQAENQI KEVEATLMEL
RAQRQQAEAE LKLARVTYSR QQRLAQTKAV SQQDLDTAAT EMAVKQAQIG TIDAQIKRNQ
ASLDTAKTNL DYTRIVAPMA GEVTQITTLQ GQTVIAAQQA PNILTLADMS AMLVKAQVSE
ADVIHLKPGQ KAWFTVLGDP LTRYEGQIKD VLPTPEKVND AIFYYARFEV PNPNGLLRLD
MTAQVHIQLT DVKNVLTIPL SALGDPVGDN RYKVKLLRNG ETREREVTIG ARNDTDVEIV
KGLEAGDEVV IGEAKPGAAQ
Length

380

Mol. Wt

41.724 kDa

pI

9.6 (calculated)

Extinction coefficient

24,410 (calc based on 9 Y, 2 W, and 0 C residues)

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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type Residues Description Notes References

motif

1-31

UniProt Manual:Signal Peptides

UniProt:P75830

Domain

60..238

PF00529 HlyD family secretion protein

PMID:19920124[8]

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Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=macA taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

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Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type Source Notes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

NCBI (Protein) (EcoliWiki Page)

GI:90111182

Escherichia coli str. K-12 substr. MG1655

NCBI (Protein) (EcoliWiki Page)

GeneID:947322

Escherichia coli str. K-12 substr. MG1655

ASAP

ASAP:ABE-0002986

Escherichia coli str. K-12 substr. MG1655

UniProt (EcoliWiki Page)

UniProtKB/Swiss-Prot:P75830

Escherichia coli str. K-12 substr. MG1655

EcoCyc

EcoCyc:G6461

Escherichia coli str. K-12 substr. MG1655

EcoGene

EcoGene:EG13694

Escherichia coli str. K-12 substr. MG1655

NCBI (Gene) (EcoliWiki Page)

GeneID:947322

Escherichia coli str. K-12 substr. MG1655

RegulonDB

RegulonDB:ECK120003061

Escherichia coli str. K-12 substr. MG1655

EchoBASE

EchoBASE:EB3458

Escherichia coli str. K-12 substr. MG1655

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Notes

Links

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References

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See Help:References for how to manage references in EcoliWiki.

  1. ↑ 1.0 1.1 1.2 1.3 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 2.4 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ 3.0 3.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  5. ↑ Kobayashi, N et al. (2001) Novel macrolide-specific ABC-type efflux transporter in Escherichia coli. J. Bacteriol. 183 5639-44 PubMed
  6. ↑ 6.0 6.1 6.2 Arifuzzaman, M et al. (2006) Large-scale identification of protein-protein interaction of Escherichia coli K-12. Genome Res. 16 686-91 PubMed
  7. ↑ 7.0 7.1 Hu, P et al. (2009) Global functional atlas of Escherichia coli encompassing previously uncharacterized proteins. PLoS Biol. 7 e96 PubMed
  8. ↑ Finn, RD et al. (2010) The Pfam protein families database. Nucleic Acids Res. 38 D211-22 PubMed

Categories

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