lpxA:Gene Product(s)

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Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

LpxA

Synonyms

UDP-N-acetylglucosamine acyltransferase[1], B0181[2][1], LpxA[2][1] , ECK0180, JW0176, b0181

Product description

LpxA[2][3];

Component of UDP-N-acetylglucosamine acyltransferase[2][3]

Lipid A biosynthesis, UDP-N-acetylglucosamine acyltransferase[4]

EC number (for enzymes)

2.3.1.129[1]

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Notes

Function

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<protect> Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0005737

cytoplasm

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0963

C

Seeded from EcoCyc (v14.0)

complete

GO:0005737

cytoplasm

GO_REF:0000023

IEA: Inferred from Electronic Annotation

SP_SL:SL-0086

C

Seeded from EcoCyc (v14.0)

complete

GO:0008610

lipid biosynthetic process

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR010137

P

Seeded from EcoCyc (v14.0)

complete

GO:0008610

lipid biosynthetic process

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0444

P

Seeded from EcoCyc (v14.0)

complete

GO:0008780

acyl-(acyl-carrier-protein)-UDP-N-acetylglucosamine O-acyltransferase activity

GOA:hamap
GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_00387

F

Seeded from EcoCyc (v14.0)

complete

GO:0008780

acyl-(acyl-carrier-protein)-UDP-N-acetylglucosamine O-acyltransferase activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR010137

F

Seeded from EcoCyc (v14.0)

complete

GO:0008780

acyl-(acyl-carrier-protein)-UDP-N-acetylglucosamine O-acyltransferase activity

GOA:spec
GO_REF:0000003

IEA: Inferred from Electronic Annotation

EC:2.3.1.129

F

Seeded from EcoCyc (v14.0)

complete

GO:0009245

lipid A biosynthetic process

GOA:hamap
GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_00387

P

Seeded from EcoCyc (v14.0)

complete

GO:0009245

lipid A biosynthetic process

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0441

P

Seeded from EcoCyc (v14.0)

complete

GO:0008780

acyl-(acyl-carrier-protein)-UDP-N-acetylglucosamine O-acyltransferase activity

PMID:3549716[5]

IDA: Inferred from Direct Assay

F

complete

GO:0005737

cytoplasm

PMID:3549716[5]

IDA: Inferred from Direct Assay

C

complete

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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type Partner Notes References Evidence

Protein

Subunits of UDP-N-acetylglucosamine acyltransferase

could be indirect

Protein

rpsT

PMID:16606699[6]

Experiment(s):EBI-1135819

Protein

fur

PMID:16606699[6]

Experiment(s):EBI-1135819

Protein

rpsD

PMID:16606699[6]

Experiment(s):EBI-1135819

Protein

rplF

PMID:16606699[6]

Experiment(s):EBI-1135819

Protein

nrdI

PMID:16606699[6]

Experiment(s):EBI-1135819

Protein

acnA

PMID:16606699[6]

Experiment(s):EBI-1135819

Protein

rplJ

PMID:16606699[6]

Experiment(s):EBI-1135819

Protein

rplQ

PMID:16606699[6]

Experiment(s):EBI-1135819

Protein

tyrB

PMID:16606699[6]

Experiment(s):EBI-1135819

Protein

rplO

PMID:16606699[6]

Experiment(s):EBI-1135819

Protein

yibL

PMID:16606699[6]

Experiment(s):EBI-1135819

Protein

yciH

PMID:16606699[6]

Experiment(s):EBI-1135819

Protein

ydiI

PMID:15690043[7]

Experiment(s):EBI-892532

Protein

mltD

PMID:15690043[7]

Experiment(s):EBI-892532

Protein

fhuB

PMID:15690043[7]

Experiment(s):EBI-892532

Protein

hcaB

PMID:15690043[7]

Experiment(s):EBI-892532

Protein

hflB

PMID:15690043[7]

Experiment(s):EBI-892532

Protein

hfq

PMID:15690043[7]

Experiment(s):EBI-892532

Protein

ribB

PMID:15690043[7]

Experiment(s):EBI-892532

Protein

rplC

PMID:15690043[7]

Experiment(s):EBI-892532

Protein

rplF

PMID:15690043[7]

Experiment(s):EBI-892532

Protein

rplL

PMID:15690043[7]

Experiment(s):EBI-892532

Protein

rplM

PMID:15690043[7]

Experiment(s):EBI-892532

Protein

rplN

PMID:15690043[7]

Experiment(s):EBI-892532

Protein

rplT

PMID:15690043[7]

Experiment(s):EBI-892532

Protein

rplU

PMID:15690043[7]

Experiment(s):EBI-892532

Protein

rplV

PMID:15690043[7]

Experiment(s):EBI-892532

Protein

rplX

PMID:15690043[7]

Experiment(s):EBI-892532

Protein

rpmB

PMID:15690043[7]

Experiment(s):EBI-892532

Protein

rpmG

PMID:15690043[7]

Experiment(s):EBI-892532

Protein

rpsB

PMID:15690043[7]

Experiment(s):EBI-892532

Protein

rpsI

PMID:15690043[7]

Experiment(s):EBI-892532

Protein

rpsJ

PMID:15690043[7]

Experiment(s):EBI-892532

Protein

queF

PMID:15690043[7]

Experiment(s):EBI-892532

Protein

ftsH

PMID:19402753[8]

LCMS(ID Probability):99.0

Protein

ribB

PMID:19402753[8]

LCMS(ID Probability):99.0

Protein

rpsC

PMID:19402753[8]

MALDI(Z-score):37.785946

Protein

ydiI

PMID:19402753[8]

LCMS(ID Probability):99.0

Protein

prs

PMID:19402753[8]

MALDI(Z-score):40.126145

Protein

fhuB

PMID:19402753[8]

LCMS(ID Probability):99.0

Protein

queF

PMID:19402753[8]

LCMS(ID Probability):99.0

Protein

hcaB

PMID:19402753[8]

LCMS(ID Probability):99.0

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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment Description Evidence Reference/Source Notes

cytoplasm

From EcoCyc[3]


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Notes

Structure and Physical Properties

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<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence

at EcoCyc 

MIDKSAFVHP TAIVEEGASI GANAHIGPFC IVGPHVEIGE GTVLKSHVVV NGHTKIGRDN
EIYQFASIGE VNQDLKYAGE PTRVEIGDRN RIRESVTIHR GTVQGGGLTK VGSDNLLMIN
AHIAHDCTVG NRCILANNAT LAGHVSVDDF AIIGGMTAVH QFCIIGAHVM VGGCSGVAQD
VPPYVIAQGN HATPFGVNIE GLKRRGFSRE AITAIRNAYK LIYRSGKTLD EVKPEIAELA
ETYPEVKAFT DFFARSTRGL IR
Length

262

Mol. Wt

28.079 kDa

pI

7.1 (calculated)

Extinction coefficient

8,940 - 9,565 (calc based on 6 Y, 0 W, and 5 C residues)

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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type Residues Description Notes References

Domain

6..34

PF00132 Bacterial transferase hexapeptide (three repeats)

PMID:19920124[9]

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Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=lpxA taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

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Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type Source Notes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

NCBI (Protein) (EcoliWiki Page)

GI:16128174

Escherichia coli str. K-12 substr. MG1655

NCBI (Protein) (EcoliWiki Page)

GeneID:944849

Escherichia coli str. K-12 substr. MG1655

ASAP

ASAP:ABE-0000618

Escherichia coli str. K-12 substr. MG1655

UniProt (EcoliWiki Page)

UniProtKB/Swiss-Prot:P0A722

Escherichia coli str. K-12 substr. MG1655

EcoCyc

EcoCyc:EG10545

Escherichia coli str. K-12 substr. MG1655

EcoGene

EcoGene:EG10545

Escherichia coli str. K-12 substr. MG1655

NCBI (Gene) (EcoliWiki Page)

GeneID:944849

Escherichia coli str. K-12 substr. MG1655

RegulonDB

RegulonDB:ECK120000538

Escherichia coli str. K-12 substr. MG1655

EchoBASE

EchoBASE:EB0540

Escherichia coli str. K-12 substr. MG1655

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Notes

Links

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References

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See Help:References for how to manage references in EcoliWiki.

  1. ↑ 1.0 1.1 1.2 1.3 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ 3.0 3.1 3.2 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  5. ↑ 5.0 5.1 Anderson, MS & Raetz, CR (1987) Biosynthesis of lipid A precursors in Escherichia coli. A cytoplasmic acyltransferase that converts UDP-N-acetylglucosamine to UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine. J. Biol. Chem. 262 5159-69 PubMed
  6. ↑ 6.00 6.01 6.02 6.03 6.04 6.05 6.06 6.07 6.08 6.09 6.10 6.11 Arifuzzaman, M et al. (2006) Large-scale identification of protein-protein interaction of Escherichia coli K-12. Genome Res. 16 686-91 PubMed
  7. ↑ 7.00 7.01 7.02 7.03 7.04 7.05 7.06 7.07 7.08 7.09 7.10 7.11 7.12 7.13 7.14 7.15 7.16 7.17 7.18 7.19 7.20 7.21 Butland, G et al. (2005) Interaction network containing conserved and essential protein complexes in Escherichia coli. Nature 433 531-7 PubMed
  8. ↑ 8.0 8.1 8.2 8.3 8.4 8.5 8.6 8.7 Hu, P et al. (2009) Global functional atlas of Escherichia coli encompassing previously uncharacterized proteins. PLoS Biol. 7 e96 PubMed
  9. ↑ Finn, RD et al. (2010) The Pfam protein families database. Nucleic Acids Res. 38 D211-22 PubMed

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