lolA:Gene Product(s)

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Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

LolA

Synonyms

chaperone for lipoproteins[1], B0891[2][1], YzzV[2][1], LolA[2][1], p20[2][1] , ECK0882, JW0874, lplA, yzzV, b0891

Product description

periplasmic chaperone, effects translocation of lipoproteins from inner membrane to outer[2][3]

Periplasmic protein responsible for sorting and transporting lipoproteins to outer membrane[4]

EC number (for enzymes)


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Notes

Function

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<protect> Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0006810

transport

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0813

P

Seeded from EcoCyc (v14.0)

complete

GO:0008565

protein transporter activity

GOA:hamap
GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_00240

F

Seeded from EcoCyc (v14.0)

complete

GO:0015031

protein transport

GOA:hamap
GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_00240

P

Seeded from EcoCyc (v14.0)

complete

GO:0015031

protein transport

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR004564

P

Seeded from EcoCyc (v14.0)

complete

GO:0015031

protein transport

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR018323

P

Seeded from EcoCyc (v14.0)

complete

GO:0015031

protein transport

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0653

P

Seeded from EcoCyc (v14.0)

complete

GO:0030288

outer membrane-bounded periplasmic space

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR004564

C

Seeded from EcoCyc (v14.0)

complete

GO:0030288

outer membrane-bounded periplasmic space

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR018323

C

Seeded from EcoCyc (v14.0)

complete

GO:0042597

periplasmic space

GOA:hamap
GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_00240

C

Seeded from EcoCyc (v14.0)

complete

GO:0042597

periplasmic space

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0574

C

Seeded from EcoCyc (v14.0)

complete

GO:0042597

periplasmic space

GO_REF:0000023

IEA: Inferred from Electronic Annotation

SP_SL:SL-0200

C

Seeded from EcoCyc (v14.0)

complete

GO:0042953

lipoprotein transport

PMID:7628437[5]

IDA: Inferred from Direct Assay

P

complete

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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type Partner Notes References Evidence

Protein

aceE

PMID:15690043[6]

Experiment(s):EBI-881219

Protein

lon

PMID:15690043[6]

Experiment(s):EBI-881219

Protein

rpsJ

PMID:15690043[6]

Experiment(s):EBI-881219

Protein

ygdI

PMID:15690043[6]

Experiment(s):EBI-888472

Protein

rplL

PMID:15690043[6]

Experiment(s):EBI-888472

Protein

rplM

PMID:15690043[6]

Experiment(s):EBI-888472

Protein

rplU

PMID:15690043[6]

Experiment(s):EBI-888472

Protein

rplV

PMID:15690043[6]

Experiment(s):EBI-888472

Protein

rplM

PMID:19402753[7]

LCMS(ID Probability):99.6

Protein

ygdI

PMID:19402753[7]

LCMS(ID Probability):99.6

Protein

rplL

PMID:19402753[7]

LCMS(ID Probability):99.6

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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment Description Evidence Reference/Source Notes

periplasm

Periplasm

PMID:7628437[5]

EchoLocation:lolA


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Notes

Structure and Physical Properties

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<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence

at EcoCyc 

MMKKIAITCA LLSSLVASSV WADAASDLKS RLDKVSSFHA SFTQKVTDGS GAAVQEGQGD
LWVKRPNLFN WHMTQPDESI LVSDGKTLWF YNPFVEQATA TWLKDATGNT PFMLIARNQS
SDWQQYNIKQ NGDDFVLTPK ASNGNLKQFT INVGRDGTIH QFSAVEQDDQ RSSYQLKSQQ
NGAVDAAKFT FTPPQGVTVD DQRK
Length

204

Mol. Wt

22.627 kDa

pI

6.7 (calculated)

Extinction coefficient

37,470 - 37,595 (calc based on 3 Y, 6 W, and 1 C residues)

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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type Residues Description Notes References

motif

1-21

UniProt Manual:Signal Peptides

UniProt:P61316

Domain

32..191

PF03548 Outer membrane lipoprotein carrier protein LolA

PMID:19920124[8]

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Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=lolA taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

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Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type Source Notes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

NCBI (Protein) (EcoliWiki Page)

GI:145698236

Escherichia coli str. K-12 substr. MG1655

NCBI (Protein) (EcoliWiki Page)

GeneID:948989

Escherichia coli str. K-12 substr. MG1655

ASAP

ASAP:ABE-0003031

Escherichia coli str. K-12 substr. MG1655

UniProt (EcoliWiki Page)

UniProtKB/Swiss-Prot:P61316

Escherichia coli str. K-12 substr. MG1655

EcoCyc

EcoCyc:G6465

Escherichia coli str. K-12 substr. MG1655

EcoGene

EcoGene:EG12684

Escherichia coli str. K-12 substr. MG1655

NCBI (Gene) (EcoliWiki Page)

GeneID:948989

Escherichia coli str. K-12 substr. MG1655

RegulonDB

RegulonDB:ECK120003065

Escherichia coli str. K-12 substr. MG1655

EchoBASE

EchoBASE:EB2548

Escherichia coli str. K-12 substr. MG1655

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Notes

Links

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References

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See Help:References for how to manage references in EcoliWiki.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 2.4 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  5. ↑ 5.0 5.1 Matsuyama, S et al. (1995) A novel periplasmic carrier protein involved in the sorting and transport of Escherichia coli lipoproteins destined for the outer membrane. EMBO J. 14 3365-72 PubMed
  6. ↑ 6.0 6.1 6.2 6.3 6.4 6.5 6.6 6.7 Butland, G et al. (2005) Interaction network containing conserved and essential protein complexes in Escherichia coli. Nature 433 531-7 PubMed
  7. ↑ 7.0 7.1 7.2 Hu, P et al. (2009) Global functional atlas of Escherichia coli encompassing previously uncharacterized proteins. PLoS Biol. 7 e96 PubMed
  8. ↑ Finn, RD et al. (2010) The Pfam protein families database. Nucleic Acids Res. 38 D211-22 PubMed

Categories

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