leuA:Gene Product(s)

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Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

LeuA

Synonyms

2-isopropylmalate synthase[1], B0074[2][1], LeuA[2][1] , ECK0076, JW0073, b0074

Product description

2-isopropylmalate synthase[2][3]

alpha-Isopropylmalate synthase[4]

EC number (for enzymes)

Has been transferred to EC-Number 2.3.3.13

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Notes

Function

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<protect> Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0003852

2-isopropylmalate synthase activity

GOA:hamap
GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_01025

F

Seeded from EcoCyc (v14.0)

complete

GO:0003852

2-isopropylmalate synthase activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR005671

F

Seeded from EcoCyc (v14.0)

complete

GO:0003852

2-isopropylmalate synthase activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR013709

F

Seeded from EcoCyc (v14.0)

complete

GO:0003852

2-isopropylmalate synthase activity

GOA:spec
GO_REF:0000003

IEA: Inferred from Electronic Annotation

EC:2.3.3.13

F

Seeded from EcoCyc (v14.0)

complete

GO:0009098

leucine biosynthetic process

GOA:hamap
GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_01025

P

Seeded from EcoCyc (v14.0)

complete

GO:0009098

leucine biosynthetic process

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR005671

P

Seeded from EcoCyc (v14.0)

complete

GO:0009098

leucine biosynthetic process

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR013709

P

Seeded from EcoCyc (v14.0)

complete

GO:0009098

leucine biosynthetic process

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0432

P

Seeded from EcoCyc (v14.0)

complete

GO:0046912

transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR002034

F

Seeded from EcoCyc (v14.0)

complete

GO:0009098

leucine biosynthetic process

PMID:4570778[5]

IMP: Inferred from Mutant Phenotype

P

complete

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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type Partner Notes References Evidence

Protein

fdnH

PMID:16606699[6]

Experiment(s):EBI-1135508

Protein

dnaK

PMID:16606699[6]

Experiment(s):EBI-1135508

Protein

htpG

PMID:16606699[6]

Experiment(s):EBI-1135508

Protein

nadE

PMID:16606699[6]

Experiment(s):EBI-1135508

Protein

phoQ

PMID:16606699[6]

Experiment(s):EBI-1135508

Protein

sucD

PMID:19402753[7]

LCMS(ID Probability):99.6

Protein

sucC

PMID:19402753[7]

LCMS(ID Probability):99.6

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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment Description Evidence Reference/Source Notes
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Notes

Structure and Physical Properties

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<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence

at EcoCyc 

MSQQVIIFDT TLRDGEQALQ ASLSVKEKLQ IALALERMGV DVMEVGFPVS SPGDFESVQT
IARQVKNSRV CALARCVEKD IDVAAESLKV AEAFRIHTFI ATSPMHIATK LRSTLDEVIE
RAIYMVKRAR NYTDDVEFSC EDAGRTPIAD LARVVEAAIN AGATTINIPD TVGYTMPFEF
AGIISGLYER VPNIDKAIIS VHTHDDLGLA VGNSLAAVHA GARQVEGAMN GIGERAGNCS
LEEVIMAIKV RKDILNVHTA INHQEIWRTS QLVSQICNMP IPANKAIVGS GAFAHSSGIH
QDGVLKNREN YEIMTPESIG LNQIQLNLTS RSGRAAVKHR MDEMGYKESE YNLDNLYDAF
LKLADKKGQV FDYDLEALAF IGKQQEEPEH FRLDYFSVQS GSNDIATAAV KLACGEEVKA
EAANGNGPVD AVYQAINRIT EYNVELVKYS LTAKGHGKDA LGQVDIVANY NGRRFHGVGL
ATDIVESSAK AMVHVLNNIW RAAEVEKELQ RKAQHNENNK ETV
Length

523

Mol. Wt

57.297 kDa

pI

5.6 (calculated)

Extinction coefficient

31,860 - 32,610 (calc based on 14 Y, 2 W, and 6 C residues)

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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type Residues Description Notes References

Initiator Methionine

1

Removed

UniProt:P09151

Domain

13..252

PF00682 HMGL-like

PMID:19920124[8]

Domain

369..500

PF08502 LeuA allosteric (dimerisation) domain

PMID:19920124[8]

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Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=leuA taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

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Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type Source Notes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

NCBI (Protein) (EcoliWiki Page)

GI:16128068

Escherichia coli str. K-12 substr. MG1655

NCBI (Protein) (EcoliWiki Page)

GeneID:947465

Escherichia coli str. K-12 substr. MG1655

ASAP

ASAP:ABE-0000267

Escherichia coli str. K-12 substr. MG1655

UniProt (EcoliWiki Page)

UniProtKB/Swiss-Prot:P09151

Escherichia coli str. K-12 substr. MG1655

EcoCyc

EcoCyc:EG11226

Escherichia coli str. K-12 substr. MG1655

EcoGene

EcoGene:EG11226

Escherichia coli str. K-12 substr. MG1655

NCBI (Gene) (EcoliWiki Page)

GeneID:947465

Escherichia coli str. K-12 substr. MG1655

RegulonDB

RegulonDB:ECK120001204

Escherichia coli str. K-12 substr. MG1655

EchoBASE

EchoBASE:EB1208

Escherichia coli str. K-12 substr. MG1655

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Notes

Links

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References

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See Help:References for how to manage references in EcoliWiki.

  1. ↑ 1.0 1.1 1.2 1.3 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  5. ↑ Somers, JM et al. (1973) Genetic fine structure of the leucine operon of Escherichia coli K-12. J. Bacteriol. 113 1268-72 PubMed
  6. ↑ 6.0 6.1 6.2 6.3 6.4 Arifuzzaman, M et al. (2006) Large-scale identification of protein-protein interaction of Escherichia coli K-12. Genome Res. 16 686-91 PubMed
  7. ↑ 7.0 7.1 Hu, P et al. (2009) Global functional atlas of Escherichia coli encompassing previously uncharacterized proteins. PLoS Biol. 7 e96 PubMed
  8. ↑ 8.0 8.1 Finn, RD et al. (2010) The Pfam protein families database. Nucleic Acids Res. 38 D211-22 PubMed

Categories

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