iscS:Gene Product(s)

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Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

IscS

Synonyms

cysteine desulfurase (tRNA sulfurtransferase), PLP-dependent[1], YzzO[2][1], YfhO[2][1], IscS[2][1], B2530[2][1] , ECK2527, JW2514, nuvC, yfhO, yzzO, b2530

Product description

cysteine desulfurase[2][3];

Component of cysteine desulfurase[3]

Cysteine desulfurase used in synthesis of Fe-S cluster; tRNA 4-thiouridine sulfurtransferase; transfers sulfur to binding partner SirA(TusA) to form C19 persulfide used to thiolate tRNA U34[4]

EC number (for enzymes) 
2.8.1.7[1]
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Notes

Function

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<protect> Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0005737

cytoplasm

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0963

C

Seeded from EcoCyc (v14.0)

complete

GO:0005737

cytoplasm

GO_REF:0000023

IEA: Inferred from Electronic Annotation

SP_SL:SL-0086

C

Seeded from EcoCyc (v14.0)

complete

GO:0006534

cysteine metabolic process

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR010240

P

Seeded from EcoCyc (v14.0)

complete

GO:0030170

pyridoxal phosphate binding

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR010240

F

Seeded from EcoCyc (v14.0)

complete

GO:0030170

pyridoxal phosphate binding

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR015421

F

Seeded from EcoCyc (v14.0)

complete

GO:0031071

cysteine desulfurase activity

GOA:hamap
GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_00331

F

Seeded from EcoCyc (v14.0)

complete

GO:0031071

cysteine desulfurase activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR010240

F

Seeded from EcoCyc (v14.0)

complete

GO:0031071

cysteine desulfurase activity

GOA:spec
GO_REF:0000003

IEA: Inferred from Electronic Annotation

EC:2.8.1.7

F

Seeded from EcoCyc (v14.0)

complete

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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type Partner Notes References Evidence

Protein

Subunits of cysteine desulfurase

could be indirect

Protein

npdA

PMID:15690043[5]

Experiment(s):EBI-887896

Protein

dnaK

PMID:15690043[5]

Experiment(s):EBI-887896

Protein

mltD

PMID:15690043[5]

Experiment(s):EBI-893577

Protein

nadE

PMID:16606699[6]

Experiment(s):EBI-1143160

Protein

rpsI

PMID:16606699[6]

Experiment(s):EBI-1143160

Protein

ydbH

PMID:16606699[6]

Experiment(s):EBI-1143160

Protein

greA

PMID:16606699[6]

Experiment(s):EBI-1143160

Protein

napC

PMID:16606699[6]

Experiment(s):EBI-1143160

Protein

bioC

PMID:16606699[6]

Experiment(s):EBI-1143160

Protein

lpxB

PMID:16606699[6]

Experiment(s):EBI-1143160

Protein

lacZ

PMID:16606699[6]

Experiment(s):EBI-1143160
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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment Description Evidence Reference/Source Notes
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Notes

Structure and Physical Properties

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<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence

at EcoCyc 

MKLPIYLDYS ATTPVDPRVA EKMMQFMTMD GTFGNPASRS HRFGWQAEEA VDIARNQIAD
LVGADPREIV FTSGATESDN LAIKGAANFY QKKGKHIITS KTEHKAVLDT CRQLEREGFE
VTYLAPQRNG IIDLKELEAA MRDDTILVSI MHVNNEIGVV QDIAAIGEMC RARGIIYHVD
ATQSVGKLPI DLSQLKVDLM SFSGHKIYGP KGIGALYVRR KPRVRIEAQM HGGGHERGMR
SGTLPVHQIV GMGEAYRIAK EEMATEMERL RGLRNRLWNG IKDIEEVYLN GDLEHGAPNI
LNVSFNYVEG ESLIMALKDL AVSSGSACTS ASLEPSYVLR ALGLNDELAH SSIRFSLGRF
TTEEEIDYTI ELVRKSIGRL RDLSPLWEMY KQGVDLNSIE WAHH
Length

404

Mol. Wt

45.09 kDa

pI

6.2 (calculated)

Extinction coefficient

41,370 - 41,745 (calc based on 13 Y, 4 W, and 3 C residues)

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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type Residues Description Notes References

Domain

5..369

PF00266 Aminotransferase class-V

PMID:19920124[7]

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Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=iscS taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

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Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type Source Notes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

NCBI (Protein) (EcoliWiki Page)

GI:49176235

Escherichia coli str. K-12 substr. MG1655

NCBI (Protein) (EcoliWiki Page)

GeneID:947004

Escherichia coli str. K-12 substr. MG1655

ASAP

ASAP:ABE-0008324

Escherichia coli str. K-12 substr. MG1655

UniProt (EcoliWiki Page)

UniProtKB/Swiss-Prot:P0A6B7

Escherichia coli str. K-12 substr. MG1655

EcoCyc

EcoCyc:G7325

Escherichia coli str. K-12 substr. MG1655

EcoGene

EcoGene:EG12677

Escherichia coli str. K-12 substr. MG1655

NCBI (Gene) (EcoliWiki Page)

GeneID:947004

Escherichia coli str. K-12 substr. MG1655

RegulonDB

RegulonDB:ECK120003897

Escherichia coli str. K-12 substr. MG1655

EchoBASE

EchoBASE:EB2542

Escherichia coli str. K-12 substr. MG1655

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Notes

Links

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References

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See Help:References for how to manage references in EcoliWiki.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 2.4 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ 3.0 3.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  5. ↑ 5.0 5.1 5.2 Butland, G et al. (2005) Interaction network containing conserved and essential protein complexes in Escherichia coli. Nature 433 531-7 PubMed
  6. ↑ 6.0 6.1 6.2 6.3 6.4 6.5 6.6 6.7 Arifuzzaman, M et al. (2006) Large-scale identification of protein-protein interaction of Escherichia coli K-12. Genome Res. 16 686-91 PubMed
  7. ↑ Finn, RD et al. (2010) The Pfam protein families database. Nucleic Acids Res. 38 D211-22 PubMed

Categories

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