hupA:Gene Product(s)

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Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

HupA

Synonyms

HU, DNA-binding transcriptional regulator, alpha subunit[1], B4000[2][1], HydL[2][1], HupA[2][1] , ECK3992, JW3964, b4000

Product description

DNA-binding protein HU-α (HU-2)[2]; Transcriptional dual regulator HU-α (HU-2)[3];

Component of HU Transcriptional dual regulator[3]

Histone-like protein HU-alpha, HU-2[4]

EC number (for enzymes)


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Notes

Function

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<protect> Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0003677

DNA binding

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000119

F

Seeded from EcoCyc (v14.0)

complete

GO:0003677

DNA binding

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR010992

F

Seeded from EcoCyc (v14.0)

complete

GO:0003677

DNA binding

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR020816

F

Seeded from EcoCyc (v14.0)

complete

GO:0003677

DNA binding

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0238

F

Seeded from EcoCyc (v14.0)

complete

GO:0016020

membrane

PMID:16858726[5]

IDA: Inferred from Direct Assay

C

Seeded from EcoCyc (v14.0)

complete

GO:0006974

response to DNA damage stimulus

PMID:11967071[6]

IEP: Inferred from Expression Pattern

P

complete

GO:0003677

DNA binding

PMID:10551881[7]

IDA: Inferred from Direct Assay

F

complete

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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type Partner Notes References Evidence

Protein

Subunits of HU Transcriptional dual regulator

could be indirect

Protein

dnaK

PMID:15690043[8]

Experiment(s):EBI-886936

Protein

malP

PMID:15690043[8]

Experiment(s):EBI-886936, EBI-884958

Protein

malQ

PMID:15690043[8]

Experiment(s):EBI-886936

Protein

rpoA

PMID:15690043[8]

Experiment(s):EBI-886936, EBI-883271

Protein

rluB

PMID:15690043[8]

Experiment(s):EBI-886936, EBI-889536

Protein

rpsD

PMID:16606699[9]

Experiment(s):EBI-1147250

Protein

dnaK

PMID:16606699[9]

Experiment(s):EBI-1147250

Protein

ompL

PMID:16606699[9]

Experiment(s):EBI-1147250

Protein

yciH

PMID:16606699[9]

Experiment(s):EBI-1147250

Protein

rplB

PMID:16606699[9]

Experiment(s):EBI-1147250

Protein

cheA

PMID:16606699[9]

Experiment(s):EBI-1147250

Protein

rplO

PMID:16606699[9]

Experiment(s):EBI-1147250

Protein

rplD

PMID:16606699[9]

Experiment(s):EBI-1147250

Protein

nrdI

PMID:16606699[9]

Experiment(s):EBI-1147250

Protein

phnN

PMID:16606699[9]

Experiment(s):EBI-1147250

Protein

ycgE

PMID:16606699[9]

Experiment(s):EBI-1147250

Protein

hupB

PMID:15690043[8]

Experiment(s):EBI-893204, EBI-884415

Protein

slyD

PMID:19402753[10]

LCMS(ID Probability):99.6

Protein

rplW

PMID:19402753[10]

LCMS(ID Probability):99.6

Protein

malQ

PMID:19402753[10]

MALDI(Z-score):23.272153

Protein

rplM

PMID:19402753[10]

LCMS(ID Probability):99.6

Protein

gpsA

PMID:19402753[10]

LCMS(ID Probability):99.6

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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment Description Evidence Reference/Source Notes
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Notes

Structure and Physical Properties

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<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence

at EcoCyc 

MNKTQLIDVI AEKAELSKTQ AKAALESTLA AITESLKEGD AVQLVGFGTF KVNHRAERTG
RNPQTGKEIK IAAANVPAFV SGKALKDAVK
Length

90

Mol. Wt

9.534 kDa

pI

10.0 (calculated)

Extinction coefficient

0 (calc based on 0 Y, 0 W, and 0 C residues)

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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type Residues Description Notes References

Domain

1..90

PF00216 Bacterial DNA-binding protein

PMID:19920124[11]

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Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=hupA taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

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Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type Source Notes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

NCBI (Protein) (EcoliWiki Page)

GI:16131830

Escherichia coli str. K-12 substr. MG1655

NCBI (Protein) (EcoliWiki Page)

GeneID:948499

Escherichia coli str. K-12 substr. MG1655

ASAP

ASAP:ABE-0013077

Escherichia coli str. K-12 substr. MG1655

UniProt (EcoliWiki Page)

UniProtKB/Swiss-Prot:P0ACF0

Escherichia coli str. K-12 substr. MG1655

EcoCyc

EcoCyc:EG10466

Escherichia coli str. K-12 substr. MG1655

EcoGene

EcoGene:EG10466

Escherichia coli str. K-12 substr. MG1655

NCBI (Gene) (EcoliWiki Page)

GeneID:948499

Escherichia coli str. K-12 substr. MG1655

RegulonDB

RegulonDB:ECK120000459

Escherichia coli str. K-12 substr. MG1655

EchoBASE

EchoBASE:EB0461

Escherichia coli str. K-12 substr. MG1655

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Notes

Links

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References

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See Help:References for how to manage references in EcoliWiki.

  1. ↑ 1.0 1.1 1.2 1.3 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ 3.0 3.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  5. ↑ Lasserre, JP et al. (2006) A complexomic study of Escherichia coli using two-dimensional blue native/SDS polyacrylamide gel electrophoresis. Electrophoresis 27 3306-21 PubMed
  6. ↑ Khil, PP & Camerini-Otero, RD (2002) Over 1000 genes are involved in the DNA damage response of Escherichia coli. Mol. Microbiol. 44 89-105 PubMed
  7. ↑ Azam, TA & Ishihama, A (1999) Twelve species of the nucleoid-associated protein from Escherichia coli. Sequence recognition specificity and DNA binding affinity. J. Biol. Chem. 274 33105-13 PubMed
  8. ↑ 8.0 8.1 8.2 8.3 8.4 8.5 Butland, G et al. (2005) Interaction network containing conserved and essential protein complexes in Escherichia coli. Nature 433 531-7 PubMed
  9. ↑ 9.00 9.01 9.02 9.03 9.04 9.05 9.06 9.07 9.08 9.09 9.10 Arifuzzaman, M et al. (2006) Large-scale identification of protein-protein interaction of Escherichia coli K-12. Genome Res. 16 686-91 PubMed
  10. ↑ 10.0 10.1 10.2 10.3 10.4 Hu, P et al. (2009) Global functional atlas of Escherichia coli encompassing previously uncharacterized proteins. PLoS Biol. 7 e96 PubMed
  11. ↑ Finn, RD et al. (2010) The Pfam protein families database. Nucleic Acids Res. 38 D211-22 PubMed

Categories

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