hslV:Gene Product(s)

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Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

HslV

Synonyms

peptidase component of the HslUV protease[1], B3932[2][1], ClpQ[2][1], YiiC[2][1], HtpO[2][1], HslV[2][1] , clpQ, ECK3924, htpO, JW3903, yiiC, b3932

Product description

peptidase component of the HslVU protease[2][3];

Component of HslV hexamer[3]; HslVU protease[3]

Heat-inducible ATP-dependent protease HslVU, protease subunit; involved in the degradation of misfolded proteins[4]

EC number (for enzymes)
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Notes

Function

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<protect> Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0004298

threonine-type endopeptidase activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001353

F

Seeded from EcoCyc (v14.0)

complete

GO:0004298

threonine-type endopeptidase activity

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0888

F

Seeded from EcoCyc (v14.0)

complete

GO:0005829

cytosol

PMID:16858726[5]

IDA: Inferred from Direct Assay

C

Seeded from EcoCyc (v14.0)

complete

GO:0005839

proteasome core complex

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001353

C

Seeded from EcoCyc (v14.0)

complete

GO:0006950

response to stress

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0346

P

Seeded from EcoCyc (v14.0)

complete

GO:0008233

peptidase activity

GOA:hamap
GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_00248

F

Seeded from EcoCyc (v14.0)

complete

GO:0008233

peptidase activity

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0645

F

Seeded from EcoCyc (v14.0)

complete

GO:0016787

hydrolase activity

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0378

F

Seeded from EcoCyc (v14.0)

complete

GO:0009408

response to heat

PMID:8349564[6]

IEP: Inferred from Expression Pattern

P

complete

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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type Partner Notes References Evidence

Protein

Subunits of HslV hexamer

could be indirect

Protein

deaD

PMID:15690043[7]

Experiment(s):EBI-880750

Protein

hslU

PMID:15690043[7]

Experiment(s):EBI-880750, EBI-886932

Protein

rplB

PMID:15690043[7]

Experiment(s):EBI-880750

Protein

tpiA

PMID:16606699[8]

Experiment(s):EBI-1147088

Protein

rplC

PMID:15690043[7]

Experiment(s):EBI-880750, EBI-886859

Protein

yggN

PMID:16606699[8]

Experiment(s):EBI-1147088

Protein

rplD

PMID:15690043[7]

Experiment(s):EBI-880750, EBI-886859

Protein

yghT

PMID:16606699[8]

Experiment(s):EBI-1147088

Protein

rplI

PMID:15690043[7]

Experiment(s):EBI-880750

Protein

prs

PMID:16606699[8]

Experiment(s):EBI-1147088

Protein

rplJ

PMID:15690043[7]

Experiment(s):EBI-880750

Protein

rplQ

PMID:16606699[8]

Experiment(s):EBI-1147088

Protein

rplS

PMID:15690043[7]

Experiment(s):EBI-880750

Protein

rplV

PMID:15690043[7]

Experiment(s):EBI-880750, EBI-886859

Protein

rpsG

PMID:15690043[7]

Experiment(s):EBI-880750

Protein

rpsM

PMID:15690043[7]

Experiment(s):EBI-880750

Protein

tufA

PMID:15690043[7]

Experiment(s):EBI-880750

Protein

rluB

PMID:15690043[7]

Experiment(s):EBI-880750

Protein

accA

PMID:15690043[7]

Experiment(s):EBI-886859

Protein

accB

PMID:15690043[7]

Experiment(s):EBI-886859

Protein

accC

PMID:15690043[7]

Experiment(s):EBI-886859

Protein

accD

PMID:15690043[7]

Experiment(s):EBI-886859

Protein

ccmB

PMID:15690043[7]

Experiment(s):EBI-886859

Protein

gabP

PMID:15690043[7]

Experiment(s):EBI-886859

Protein

rplL

PMID:15690043[7]

Experiment(s):EBI-886859

Protein

rplU

PMID:15690043[7]

Experiment(s):EBI-886859

Protein

rplX

PMID:15690043[7]

Experiment(s):EBI-886859

Protein

rpmC

PMID:15690043[7]

Experiment(s):EBI-886859

Protein

rpmG

PMID:15690043[7]

Experiment(s):EBI-886859

Protein

rpsP

PMID:15690043[7]

Experiment(s):EBI-886859

Protein

yihI

PMID:15690043[7]

Experiment(s):EBI-886859

Protein

yhjD

PMID:15690043[7]

Experiment(s):EBI-886859

Protein

rplS

PMID:19402753[9]

LCMS(ID Probability):99.0 MALDI(Z-score):17.053160

Protein

yhjD

PMID:19402753[9]

LCMS(ID Probability):99.0

Protein

lon

PMID:19402753[9]

MALDI(Z-score):28.228419

Protein

yihI

PMID:19402753[9]

LCMS(ID Probability):99.0

Protein

rplD

PMID:19402753[9]

LCMS(ID Probability):99.0 MALDI(Z-score):17.053160

Protein

accB

PMID:19402753[9]

LCMS(ID Probability):99.0

Protein

gabP

PMID:19402753[9]

LCMS(ID Probability):99.0

Protein

Subunits of HslVU protease

could be indirect


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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment Description Evidence Reference/Source Notes
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Notes

Structure and Physical Properties

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<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence

at EcoCyc 

MTTIVSVRRN GHVVIAGDGQ ATLGNTVMKG NVKKVRRLYN DKVIAGFAGG TADAFTLFEL
FERKLEMHQG HLVKAAVELA KDWRTDRMLR KLEALLAVAD ETASLIITGN GDVVQPENDL
IAIGSGGPYA QAAARALLEN TELSAREIAE KALDIAGDIC IYTNHFHTIE ELSYKA
Length

176

Mol. Wt

19.092 kDa

pI

6.4 (calculated)

Extinction coefficient

11,460 - 11,585 (calc based on 4 Y, 1 W, and 1 C residues)

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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type Residues Description Notes References

Initiator Methionine

1

Removed (Probable)

UniProt:P0A7B8

Domain

2..172

PF00227 Proteasome subunit

PMID:19920124[10]

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Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=hslV taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

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Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type Source Notes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

NCBI (Protein) (EcoliWiki Page)

GI:16131770

Escherichia coli str. K-12 substr. MG1655

NCBI (Protein) (EcoliWiki Page)

GeneID:948429

Escherichia coli str. K-12 substr. MG1655

ASAP

ASAP:ABE-0012845

Escherichia coli str. K-12 substr. MG1655

UniProt (EcoliWiki Page)

UniProtKB/Swiss-Prot:P0A7B8

Escherichia coli str. K-12 substr. MG1655

EcoCyc

EcoCyc:EG11676

Escherichia coli str. K-12 substr. MG1655

EcoGene

EcoGene:EG11676

Escherichia coli str. K-12 substr. MG1655

NCBI (Gene) (EcoliWiki Page)

GeneID:948429

Escherichia coli str. K-12 substr. MG1655

RegulonDB

RegulonDB:ECK120001619

Escherichia coli str. K-12 substr. MG1655

EchoBASE

EchoBASE:EB1627

Escherichia coli str. K-12 substr. MG1655

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Notes

Links

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References

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See Help:References for how to manage references in EcoliWiki.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 2.4 2.5 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ 3.0 3.1 3.2 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  5. ↑ Lasserre, JP et al. (2006) A complexomic study of Escherichia coli using two-dimensional blue native/SDS polyacrylamide gel electrophoresis. Electrophoresis 27 3306-21 PubMed
  6. ↑ Chuang, SE & Blattner, FR (1993) Characterization of twenty-six new heat shock genes of Escherichia coli. J. Bacteriol. 175 5242-52 PubMed
  7. ↑ 7.00 7.01 7.02 7.03 7.04 7.05 7.06 7.07 7.08 7.09 7.10 7.11 7.12 7.13 7.14 7.15 7.16 7.17 7.18 7.19 7.20 7.21 7.22 7.23 7.24 7.25 7.26 Butland, G et al. (2005) Interaction network containing conserved and essential protein complexes in Escherichia coli. Nature 433 531-7 PubMed
  8. ↑ 8.0 8.1 8.2 8.3 8.4 Arifuzzaman, M et al. (2006) Large-scale identification of protein-protein interaction of Escherichia coli K-12. Genome Res. 16 686-91 PubMed
  9. ↑ 9.0 9.1 9.2 9.3 9.4 9.5 9.6 Hu, P et al. (2009) Global functional atlas of Escherichia coli encompassing previously uncharacterized proteins. PLoS Biol. 7 e96 PubMed
  10. ↑ Finn, RD et al. (2010) The Pfam protein families database. Nucleic Acids Res. 38 D211-22 PubMed

Categories

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