hslU:Gene Product(s)
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| Nomenclature | Function | Interactions | Localization | Sequence | Domains | Structure | Resources | Accessions | Links | References | Suggestions |
Nomenclature
See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.
| Standard name |
HslU |
|---|---|
| Synonyms |
molecular chaperone and ATPase component of HslUV protease[1], B3931[2][1], HtpI[2][1], ClpY[2][1], HslU[2][1], D48.5[2][1] , clpY, ECK3923, htpI, JW3902, b3931 |
| Product description |
ATPase component of the HslVU protease[2][3]; Component of HslU hexamer[3]; HslVU protease[3] Heat-inducible ATP-dependent protease HslVU, ATPase subunit; involved in the degradation of misfolded proteins; heat shock protein D48.5[4] |
| EC number (for enzymes) |
|
| edit table |
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Notes
Function
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Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000166 |
nucleotide binding |
GOA:interpro |
IEA: Inferred from Electronic Annotation |
F |
Seeded from EcoCyc (v14.0) |
complete | ||
| GO:0000166 |
nucleotide binding |
GOA:spkw |
IEA: Inferred from Electronic Annotation |
F |
Seeded from EcoCyc (v14.0) |
complete | ||
| GO:0005515 |
protein binding |
GOA:interpro |
IEA: Inferred from Electronic Annotation |
F |
Seeded from EcoCyc (v14.0) |
complete | ||
| GO:0005524 |
ATP binding |
GOA:hamap |
IEA: Inferred from Electronic Annotation |
F |
Seeded from EcoCyc (v14.0) |
complete | ||
| GO:0005524 |
ATP binding |
GOA:interpro |
IEA: Inferred from Electronic Annotation |
F |
Seeded from EcoCyc (v14.0) |
complete | ||
| GO:0005524 |
ATP binding |
GOA:interpro |
IEA: Inferred from Electronic Annotation |
F |
Seeded from EcoCyc (v14.0) |
complete | ||
| GO:0005524 |
ATP binding |
GOA:interpro |
IEA: Inferred from Electronic Annotation |
F |
Seeded from EcoCyc (v14.0) |
complete | ||
| GO:0005524 |
ATP binding |
GOA:spkw |
IEA: Inferred from Electronic Annotation |
F |
Seeded from EcoCyc (v14.0) |
complete | ||
| GO:0005737 |
cytoplasm |
GOA:hamap |
IEA: Inferred from Electronic Annotation |
C |
Seeded from EcoCyc (v14.0) |
complete | ||
| GO:0005737 |
cytoplasm |
GOA:interpro |
IEA: Inferred from Electronic Annotation |
C |
Seeded from EcoCyc (v14.0) |
complete | ||
| GO:0005737 |
cytoplasm |
GOA:spkw |
IEA: Inferred from Electronic Annotation |
C |
Seeded from EcoCyc (v14.0) |
complete | ||
| GO:0005737 |
cytoplasm |
IEA: Inferred from Electronic Annotation |
SP_SL:SL-0086 |
C |
Seeded from EcoCyc (v14.0) |
complete | ||
| GO:0006950 |
response to stress |
GOA:spkw |
IEA: Inferred from Electronic Annotation |
P |
Seeded from EcoCyc (v14.0) |
complete | ||
| GO:0008233 |
peptidase activity |
GOA:hamap |
IEA: Inferred from Electronic Annotation |
F |
Seeded from EcoCyc (v14.0) |
complete | ||
| GO:0009376 |
HslUV protease complex |
GOA:interpro |
IEA: Inferred from Electronic Annotation |
C |
Seeded from EcoCyc (v14.0) |
complete | ||
| GO:0016020 |
membrane |
IDA: Inferred from Direct Assay |
C |
Seeded from EcoCyc (v14.0) |
complete | |||
| GO:0016887 |
ATPase activity |
GOA:interpro |
IEA: Inferred from Electronic Annotation |
F |
Seeded from EcoCyc (v14.0) |
complete | ||
| GO:0009408 |
response to heat |
IEP: Inferred from Expression Pattern |
P |
complete | ||||
| GO:0017111 |
nucleoside-triphosphatase activity |
GOA:interpro |
IEA: Inferred from Electronic Annotation |
F |
Seeded from EcoCyc (v14.0) |
complete | ||
| GO:0070011 |
peptidase activity, acting on L-amino acid peptides |
GOA:interpro |
IEA: Inferred from Electronic Annotation |
F |
Seeded from EcoCyc (v14.0) |
complete | ||
| edit table |
Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.
| Partner Type | Partner | Notes | References | Evidence |
|---|---|---|---|---|
|
Protein |
Subunits of HslU hexamer |
could be indirect |
||
|
Protein |
cca |
Experiment(s):EBI-880782 | ||
|
Protein |
cysW |
Experiment(s):EBI-880782 | ||
|
Protein |
dnaJ |
Experiment(s):EBI-880782, EBI-886932 | ||
|
Protein |
dnaK |
Experiment(s):EBI-880782, EBI-886932 | ||
|
Protein |
ftsZ |
Experiment(s):EBI-880782 | ||
|
Protein |
fusA |
Experiment(s):EBI-880782 | ||
|
Protein |
gatZ |
Experiment(s):EBI-880782 | ||
|
Protein |
gpmB |
Experiment(s):EBI-880782 | ||
|
Protein |
lon |
Experiment(s):EBI-880782 | ||
|
Protein |
metE |
Experiment(s):EBI-880782 | ||
|
Protein |
metK |
Experiment(s):EBI-880782 | ||
|
Protein |
mreB |
Experiment(s):EBI-880782 | ||
|
Protein |
narG |
Experiment(s):EBI-880782 | ||
|
Protein |
nuoC |
Experiment(s):EBI-880782 | ||
|
Protein |
pstB |
Experiment(s):EBI-880782 | ||
|
Protein |
recA |
Experiment(s):EBI-880782 | ||
|
Protein |
rplJ |
Experiment(s):EBI-880782 | ||
|
Protein |
secA |
Experiment(s):EBI-880782 | ||
|
Protein |
tufA |
Experiment(s):EBI-880782, EBI-886932 | ||
|
Protein |
ygeG |
Experiment(s):EBI-880782 | ||
|
Protein |
accB |
Experiment(s):EBI-886932 | ||
|
Protein |
accC |
Experiment(s):EBI-886932 | ||
|
Protein |
accD |
Experiment(s):EBI-886932 | ||
|
Protein |
ydeN |
Experiment(s):EBI-886932 | ||
|
Protein |
ccmB |
Experiment(s):EBI-886932 | ||
|
Protein |
iciA |
Experiment(s):EBI-886932 | ||
|
Protein |
mglB |
Experiment(s):EBI-886932 | ||
|
Protein |
ompX |
Experiment(s):EBI-886932 | ||
|
Protein |
ribD |
Experiment(s):EBI-886932 | ||
|
Protein |
rplC |
Experiment(s):EBI-886932 | ||
|
Protein |
rplD |
Experiment(s):EBI-886932 | ||
|
Protein |
rplL |
Experiment(s):EBI-886932 | ||
|
Protein |
rplM |
Experiment(s):EBI-886932 | ||
|
Protein |
rplP |
Experiment(s):EBI-886932 | ||
|
Protein |
rpsB |
Experiment(s):EBI-886932 | ||
|
Protein |
rpsE |
Experiment(s):EBI-886932 | ||
|
Protein |
rpsG |
Experiment(s):EBI-886932 | ||
|
Protein |
rpsJ |
Experiment(s):EBI-886932 | ||
|
Protein |
thrA |
Experiment(s):EBI-886932 | ||
|
Protein |
ydgA |
Experiment(s):EBI-886932 | ||
|
Protein |
rpsJ |
LCMS(ID Probability):99.6 | ||
|
Protein |
fusA |
MALDI(Z-score):24.085201 | ||
|
Protein |
ribD |
LCMS(ID Probability):99.0 | ||
|
Protein |
recA |
MALDI(Z-score):32.936622 | ||
|
Protein |
metE |
MALDI(Z-score):25.787725 | ||
|
Protein |
hslV |
LCMS(ID Probability):99.6 MALDI(Z-score):17.053160 | ||
|
Protein |
metK |
MALDI(Z-score):33.658153 | ||
|
Protein |
ompX |
LCMS(ID Probability):99.0 | ||
|
Protein |
tufB |
MALDI(Z-score):20.769725 | ||
|
Protein |
dnaJ |
LCMS(ID Probability):99.6 MALDI(Z-score):17.319184 | ||
|
Protein |
mreB |
MALDI(Z-score):36.427134 | ||
|
Protein |
gatZ |
MALDI(Z-score):25.337942 | ||
|
Protein |
ydgA |
LCMS(ID Probability):99.6 | ||
|
Protein |
argP |
LCMS(ID Probability):99.6 | ||
|
Protein |
thrA |
LCMS(ID Probability):99.6 | ||
|
Protein |
mglB |
LCMS(ID Probability):99.6 | ||
|
Protein |
accB |
LCMS(ID Probability):99.0 | ||
|
Protein |
ydeN |
LCMS(ID Probability):99.6 | ||
|
Protein |
rplL |
LCMS(ID Probability):99.6 | ||
|
Protein |
Subunits of HslVU protease |
could be indirect |
| |
| edit table |
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Notes
Localization
See Help:Product_localization for how to add or edit information in this section of EcoliWiki.
| Compartment | Description | Evidence | Reference/Source | Notes |
|---|---|---|---|---|
| edit table |
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Notes
Structure and Physical Properties
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Physical Properties
See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.
| Name | |
|---|---|
| Sequence |
MSEMTPREIV SELDKHIIGQ DNAKRSVAIA LRNRWRRMQL NEELRHEVTP KNILMIGPTG VGKTEIARRL AKLANAPFIK VEATKFTEVG YVGKEVDSII RDLTDAAVKM VRVQAIEKNR YRAEELAEER ILDVLIPPAK NNWGQTEQQQ EPSAARQAFR KKLREGQLDD KEIEIDLAAA PMGVEIMAPP GMEEMTSQLQ SMFQNLGGQK QKARKLKIKD AMKLLIEEEA AKLVNPEELK QDAIDAVEQH GIVFIDEIDK ICKRGESSGP DVSREGVQRD LLPLVEGCTV STKHGMVKTD HILFIASGAF QIAKPSDLIP ELQGRLPIRV ELQALTTSDF ERILTEPNAS ITVQYKALMA TEGVNIEFTD SGIKRIAEAA WQVNESTENI GARRLHTVLE RLMEEISYDA SDLSGQNITI DADYVSKHLD ALVADEDLSR FIL |
| Length |
443 |
| Mol. Wt |
49.594 kDa |
| pI |
5.2 (calculated) |
| Extinction coefficient |
23,950 - 24,200 (calc based on 5 Y, 3 W, and 2 C residues) |
| edit table |
Domains/Motifs/Modification Sites
|
See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.
|
<motif_map/> |
|
Structure
| </protect>
Structure figures<protect> | ||||||
Notes
Gene Product Resources
See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.
| Resource type | Source | Notes/Reference |
|---|---|---|
| edit table |
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Notes
Accessions in Other Databases
See Help:Gene_accessions for help with entering information into the Gene Accessions table.
| Database | Accession | Notes |
|---|---|---|
|
Escherichia coli str. K-12 substr. MG1655 | ||
|
Escherichia coli str. K-12 substr. MG1655 | ||
|
Escherichia coli str. K-12 substr. MG1655 | ||
|
Escherichia coli str. K-12 substr. MG1655 | ||
|
Escherichia coli str. K-12 substr. MG1655 | ||
|
Escherichia coli str. K-12 substr. MG1655 | ||
|
Escherichia coli str. K-12 substr. MG1655 | ||
|
Escherichia coli str. K-12 substr. MG1655 | ||
|
Escherichia coli str. K-12 substr. MG1655 | ||
| edit table |
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Notes
Links
| Name | URL | Comments |
|---|---|---|
| edit table |
References
See Help:References for how to manage references in EcoliWiki.
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
- ↑ 3.0 3.1 3.2 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
- ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
- ↑ Lasserre, JP et al. (2006) A complexomic study of Escherichia coli using two-dimensional blue native/SDS polyacrylamide gel electrophoresis. Electrophoresis 27 3306-21 PubMed
- ↑ Chuang, SE & Blattner, FR (1993) Characterization of twenty-six new heat shock genes of Escherichia coli. J. Bacteriol. 175 5242-52 PubMed
- ↑ 7.00 7.01 7.02 7.03 7.04 7.05 7.06 7.07 7.08 7.09 7.10 7.11 7.12 7.13 7.14 7.15 7.16 7.17 7.18 7.19 7.20 7.21 7.22 7.23 7.24 7.25 7.26 7.27 7.28 7.29 7.30 7.31 7.32 7.33 7.34 7.35 7.36 7.37 7.38 7.39 Butland, G et al. (2005) Interaction network containing conserved and essential protein complexes in Escherichia coli. Nature 433 531-7 PubMed
- ↑ 8.00 8.01 8.02 8.03 8.04 8.05 8.06 8.07 8.08 8.09 8.10 8.11 8.12 8.13 8.14 8.15 8.16 8.17 8.18 Hu, P et al. (2009) Global functional atlas of Escherichia coli encompassing previously uncharacterized proteins. PLoS Biol. 7 e96 PubMed
- ↑ 9.0 9.1 9.2 Finn, RD et al. (2010) The Pfam protein families database. Nucleic Acids Res. 38 D211-22 PubMed
Categories
- GO:0000166 ! nucleotide binding
- GO:0005515 ! protein binding
- GO:0005524 ! ATP binding
- GO:0005737 ! cytoplasm
- GO:0006950 ! response to stress
- GO:0008233 ! peptidase activity
- GO:0009376 ! HslUV protease complex
- GO:0016020 ! membrane
- GO:0016887 ! ATPase activity
- GO:0009408 ! response to heat
- GO:0017111 ! nucleoside-triphosphatase activity
- GO:0070011 ! peptidase activity, acting on L-amino acid peptides
- Proteins
