hscC:Gene Product(s)

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Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

HscC

Synonyms

Hsp70 family chaperone Hsc62, binds to RpoD and inhibits transcription[1], YbeW[2][1], HscC[2][1], B0650[2][1], Hsc62[2][1] , ECK0643, JW0645, ybeW, b0650

Product description

Hsc62, Hsp70 family chaperone, binds to RpoD and inhibits transcription[2][3]

Hsc62, DnaK-like chaperone; binds to RpoD and inhibits transcription; inhibits growth when overexpressed; Hsc56(DjlC) is DnaJ-like co-chaperone; ATPase activity is stimulated by GrpE, DjlC; mutant grows slow and is hypersensitive to Cd(II) and UV[4]

EC number (for enzymes)


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Notes

Function

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<protect> Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type Partner Notes References Evidence

Protein

yffL

PMID:15690043[5]

Experiment(s):EBI-880828

Protein

clpA

PMID:15690043[5]

Experiment(s):EBI-880828

Protein

rplJ

PMID:15690043[5]

Experiment(s):EBI-880828

Protein

rpsB

PMID:15690043[5]

Experiment(s):EBI-880828

Protein

tnaA

PMID:15690043[5]

Experiment(s):EBI-880828

Protein

helD

PMID:16606699[6]

Experiment(s):EBI-1137559

Protein

hslR

PMID:16606699[6]

Experiment(s):EBI-1137559

Protein

narZ

PMID:16606699[6]

Experiment(s):EBI-1137559

Protein

narG

PMID:16606699[6]

Experiment(s):EBI-1137559

Protein

gyrA

PMID:16606699[6]

Experiment(s):EBI-1137559

Protein

greA

PMID:16606699[6]

Experiment(s):EBI-1137559

Protein

topA

PMID:16606699[6]

Experiment(s):EBI-1137559

Protein

rplF

PMID:16606699[6]

Experiment(s):EBI-1137559

Protein

yfdS

PMID:16606699[6]

Experiment(s):EBI-1137559

Protein

rplQ

PMID:16606699[6]

Experiment(s):EBI-1137559

Protein

sdhA

PMID:16606699[6]

Experiment(s):EBI-1137559

Protein

rpsE

PMID:16606699[6]

Experiment(s):EBI-1137559

Protein

nuoG

PMID:16606699[6]

Experiment(s):EBI-1137559

Protein

ydcP

PMID:16606699[6]

Experiment(s):EBI-1137559

Protein

rplJ

PMID:16606699[6]

Experiment(s):EBI-1137559

Protein

pflB

PMID:16606699[6]

Experiment(s):EBI-1137559

Protein

rpsB

PMID:16606699[6]

Experiment(s):EBI-1137559

Protein

rpoB

PMID:16606699[6]

Experiment(s):EBI-1137559

Protein

mukB

PMID:16606699[6]

Experiment(s):EBI-1137559

Protein

rpsI

PMID:16606699[6]

Experiment(s):EBI-1137559

Protein

rpsC

PMID:16606699[6]

Experiment(s):EBI-1137559

Protein

rpsD

PMID:16606699[6]

Experiment(s):EBI-1137559

Protein

ada

PMID:16606699[6]

Experiment(s):EBI-1137559

Protein

rpmE

PMID:16606699[6]

Experiment(s):EBI-1137559

Protein

rplR

PMID:16606699[6]

Experiment(s):EBI-1137559

Protein

yciH

PMID:16606699[6]

Experiment(s):EBI-1137559

Protein

yhjK

PMID:15690043[5]

Experiment(s):EBI-893359

Protein

yffL

PMID:19402753[7]

MALDI(Z-score):17.053160

Protein

yhjK

PMID:19402753[7]

LCMS(ID Probability):99.4

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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment Description Evidence Reference/Source Notes
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Notes

Structure and Physical Properties

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<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence

at EcoCyc 

MDNAELAIGI DLGTTNSLIA VWKDGAAQLI PNKFGEYLTP SIISMDENNH ILVGKPAVSR
RTSHPDKTAA LFKRAMGSNT NWRLGSDTFN APELSSLVLR SLKEDAEEFL QRPIKDVVIS
VPAYFSDEQR KHTRLAAELA GLNAVRLINE PTAAAMAYGL HTQQNTRSLV FDLGGGTFDV
TVLEYATPVI EVHASAGDNF LGGEDFTHML VDEVLKRADV ARTTLNESEL AALYACVEAA
KCSNQSPLHI RWQYQEETRE CEFYENELED LWLPLLNRLR VPIEQALRDA RLKPSQIDSL
VLVGGASQMP LVQRIAVRLF GKLPYQSYDP STIVALGAAI QAACRLRSED IEEVILTDIC
PYSLGVEVNR QGVSGIFSPI IERNTTVPVS RVETYSTMHP EQDSITVNVY QGENHKVKNN
ILVESFDVPL KKTGAYQSID IRFSYDINGL LEVDVLLEDG SVKSRVINHS PVTLSAQQIE
ESRTRLSALK IYPRDMLINR TFKAKLEELW ARALGDEREE IGRVITDFDA ALQSNDMARV
DEVRRRASDY LAIEIP
Length

556

Mol. Wt

61.987 kDa

pI

4.9 (calculated)

Extinction coefficient

51,340 - 51,965 (calc based on 16 Y, 5 W, and 5 C residues)

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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type Residues Description Notes References

Domain

80..551

PF00012 Hsp70 protein

PMID:19920124[8]

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Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=hscC taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

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Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type Source Notes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

NCBI (Protein) (EcoliWiki Page)

GI:16128633

Escherichia coli str. K-12 substr. MG1655

NCBI (Protein) (EcoliWiki Page)

GeneID:945218

Escherichia coli str. K-12 substr. MG1655

ASAP

ASAP:ABE-0002225

Escherichia coli str. K-12 substr. MG1655

UniProt (EcoliWiki Page)

UniProtKB/Swiss-Prot:P77319

Escherichia coli str. K-12 substr. MG1655

EcoCyc

EcoCyc:G6357

Escherichia coli str. K-12 substr. MG1655

EcoGene

EcoGene:EG13653

Escherichia coli str. K-12 substr. MG1655

NCBI (Gene) (EcoliWiki Page)

GeneID:945218

Escherichia coli str. K-12 substr. MG1655

RegulonDB

RegulonDB:ECK120002964

Escherichia coli str. K-12 substr. MG1655

EchoBASE

EchoBASE:EB3417

Escherichia coli str. K-12 substr. MG1655

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Notes

Links

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References

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See Help:References for how to manage references in EcoliWiki.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 2.4 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  5. ↑ 5.0 5.1 5.2 5.3 5.4 5.5 Butland, G et al. (2005) Interaction network containing conserved and essential protein complexes in Escherichia coli. Nature 433 531-7 PubMed
  6. ↑ 6.00 6.01 6.02 6.03 6.04 6.05 6.06 6.07 6.08 6.09 6.10 6.11 6.12 6.13 6.14 6.15 6.16 6.17 6.18 6.19 6.20 6.21 6.22 6.23 6.24 6.25 Arifuzzaman, M et al. (2006) Large-scale identification of protein-protein interaction of Escherichia coli K-12. Genome Res. 16 686-91 PubMed
  7. ↑ 7.0 7.1 Hu, P et al. (2009) Global functional atlas of Escherichia coli encompassing previously uncharacterized proteins. PLoS Biol. 7 e96 PubMed
  8. ↑ Finn, RD et al. (2010) The Pfam protein families database. Nucleic Acids Res. 38 D211-22 PubMed

Categories

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