hisI:Gene Product(s)

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Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

HisI

Synonyms

fused phosphoribosyl-AMP cyclohydrolase[1], phosphoribosyl-ATP pyrophosphatase[1], B2026[2][1], HisE[2][1], HisI[2][1] , ECK2021, hisE, hisIE, JW2008, b2026

Product description

PR-ATP pyrophosphatase/PR-AMP cyclohydrolase, bifunctional[3]

EC number (for enzymes)
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Notes

Function

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<protect> Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000105

histidine biosynthetic process

GOA:hamap
GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_01019

P

Seeded from EcoCyc (v14.0)

complete

GO:0000105

histidine biosynthetic process

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR002496

P

Seeded from EcoCyc (v14.0)

complete

GO:0000105

histidine biosynthetic process

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR008179

P

Seeded from EcoCyc (v14.0)

complete

GO:0000105

histidine biosynthetic process

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0368

P

Seeded from EcoCyc (v14.0)

complete

GO:0000166

nucleotide binding

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0547

F

Seeded from EcoCyc (v14.0)

complete

GO:0004635

phosphoribosyl-AMP cyclohydrolase activity

GOA:hamap
GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_01019

F

Seeded from EcoCyc (v14.0)

complete

GO:0004635

phosphoribosyl-AMP cyclohydrolase activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR002496

F

Seeded from EcoCyc (v14.0)

complete

GO:0004635

phosphoribosyl-AMP cyclohydrolase activity

GOA:spec
GO_REF:0000003

IEA: Inferred from Electronic Annotation

EC:3.5.4.19

F

Seeded from EcoCyc (v14.0)

complete

GO:0004636

phosphoribosyl-ATP diphosphatase activity

GOA:hamap
GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_01019

F

Seeded from EcoCyc (v14.0)

complete

GO:0004636

phosphoribosyl-ATP diphosphatase activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR008179

F

Seeded from EcoCyc (v14.0)

complete

GO:0004636

phosphoribosyl-ATP diphosphatase activity

GOA:spec
GO_REF:0000003

IEA: Inferred from Electronic Annotation

EC:3.6.1.31

F

Seeded from EcoCyc (v14.0)

complete

GO:0005524

ATP binding

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0067

F

Seeded from EcoCyc (v14.0)

complete

GO:0005737

cytoplasm

GOA:hamap
GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_01019

C

Seeded from EcoCyc (v14.0)

complete

GO:0005737

cytoplasm

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0963

C

Seeded from EcoCyc (v14.0)

complete

GO:0005737

cytoplasm

GO_REF:0000023

IEA: Inferred from Electronic Annotation

SP_SL:SL-0086

C

Seeded from EcoCyc (v14.0)

complete

GO:0008652

cellular amino acid biosynthetic process

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0028

P

Seeded from EcoCyc (v14.0)

complete

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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type Partner Notes References Evidence

Protein

rpsE

PMID:16606699[4]

Experiment(s):EBI-1141661

Protein

yagR

PMID:16606699[4]

Experiment(s):EBI-1141661

Protein

yghW

PMID:16606699[4]

Experiment(s):EBI-1141661

Protein

frsA

PMID:16606699[4]

Experiment(s):EBI-1141661

Protein

dld

PMID:16606699[4]

Experiment(s):EBI-1141661

Protein

fpr

PMID:16606699[4]

Experiment(s):EBI-1141661

Protein

mdoG

PMID:16606699[4]

Experiment(s):EBI-1141661

Protein

yjhG

PMID:16606699[4]

Experiment(s):EBI-1141661

Protein

rpsD

PMID:16606699[4]

Experiment(s):EBI-1141661

Protein

manC

PMID:16606699[4]

Experiment(s):EBI-1141661

Protein

cspI

PMID:16606699[4]

Experiment(s):EBI-1141661

Protein

rpsQ

PMID:16606699[4]

Experiment(s):EBI-1141661

Protein

ymfG

PMID:16606699[4]

Experiment(s):EBI-1141661

Protein

prpE

PMID:16606699[4]

Experiment(s):EBI-1141661

Protein

deoA

PMID:16606699[4]

Experiment(s):EBI-1141661
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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment Description Evidence Reference/Source Notes
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Notes

Structure and Physical Properties

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<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence

at EcoCyc 

MLTEQQRREL DWEKTDGLMP VIVQHAVSGE VLMLGYMNPE ALDKTLESGK VTFFSRTKQR
LWTKGETSGN FLNVVSIAPD CDNDTLLVLA NPIGPTCHKG TSSCFGDTAH QWLFLYQLEQ
LLAERKSADP ETSYTAKLYA SGTKRIAQKV GEEGVETALA ATVHDRFELT NEASDLMYHL
LVLLQDQGLD LTTVIENLRK RHQ
Length

203

Mol. Wt

22.755 kDa

pI

5.2 (calculated)

Extinction coefficient

23,950 - 24,325 (calc based on 5 Y, 3 W, and 3 C residues)

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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type Residues Description Notes References

Domain

33..107

PF01502 Phosphoribosyl-AMP cyclohydrolase

PMID:19920124[5]

Domain

115..202

PF01503 Phosphoribosyl-ATP pyrophosphohydrolase

PMID:19920124[5]

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<motif_map/>

Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=hisI taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

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Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type Source Notes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

NCBI (Protein) (EcoliWiki Page)

GI:16129967

Escherichia coli str. K-12 substr. MG1655

NCBI (Protein) (EcoliWiki Page)

GeneID:946515

Escherichia coli str. K-12 substr. MG1655

ASAP

ASAP:ABE-0006729

Escherichia coli str. K-12 substr. MG1655

UniProt (EcoliWiki Page)

UniProtKB/Swiss-Prot:P06989

Escherichia coli str. K-12 substr. MG1655

EcoCyc

EcoCyc:EG10451

Escherichia coli str. K-12 substr. MG1655

EcoGene

EcoGene:EG10451

Escherichia coli str. K-12 substr. MG1655

NCBI (Gene) (EcoliWiki Page)

GeneID:946515

Escherichia coli str. K-12 substr. MG1655

RegulonDB

RegulonDB:ECK120000444

Escherichia coli str. K-12 substr. MG1655

EchoBASE

EchoBASE:EB0446

Escherichia coli str. K-12 substr. MG1655

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Notes

Links

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References

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See Help:References for how to manage references in EcoliWiki.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  4. ↑ 4.00 4.01 4.02 4.03 4.04 4.05 4.06 4.07 4.08 4.09 4.10 4.11 4.12 4.13 4.14 Arifuzzaman, M et al. (2006) Large-scale identification of protein-protein interaction of Escherichia coli K-12. Genome Res. 16 686-91 PubMed
  5. ↑ 5.0 5.1 Finn, RD et al. (2010) The Pfam protein families database. Nucleic Acids Res. 38 D211-22 PubMed

Categories

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