hisH:Gene Product(s)

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Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

HisH

Synonyms

imidazole glycerol phosphate synthase, glutamine amidotransferase subunit with HisF[1], B2023[2][1], HisH[2][1], hisH enzyme[2][1] , ECK2018, JW2005, b2023

Product description

imidazole glycerol phosphate synthase, HisH subunit[2][3];

Component of imidazole glycerol phosphate synthase[2][3]

Amidotransferase component of imidazole glycerol phosphate (IGP) synthase[4]

EC number (for enzymes)

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Notes

Function

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<protect> Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000105

histidine biosynthetic process

GOA:hamap
GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_00278

P

Seeded from EcoCyc (v14.0)

complete

GO:0000105

histidine biosynthetic process

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR010139

P

Seeded from EcoCyc (v14.0)

complete

GO:0000105

histidine biosynthetic process

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR016226

P

Seeded from EcoCyc (v14.0)

complete

GO:0000105

histidine biosynthetic process

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0368

P

Seeded from EcoCyc (v14.0)

complete

GO:0000107

imidazoleglycerol-phosphate synthase activity

GOA:hamap
GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_00278

F

Seeded from EcoCyc (v14.0)

complete

GO:0006541

glutamine metabolic process

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR011702

P

Seeded from EcoCyc (v14.0)

complete

GO:0006541

glutamine metabolic process

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0315

P

Seeded from EcoCyc (v14.0)

complete

Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type Partner Notes References Evidence

Protein

Subunits of imidazole glycerol phosphate synthase

could be indirect

Protein

groL

PMID:16606699[5]

Experiment(s):EBI-1141654

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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment Description Evidence Reference/Source Notes

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Notes

Structure and Physical Properties

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<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence

at EcoCyc

MNVVILDTGC ANLNSVKSAI ARHGYEPKVS RDPDVVLLAD KLFLPGVGTA QAAMDQVRER
ELFDLIKACT QPVLGICLGM QLLGRRSEES NGVDLLGIID EDVPKMTDFG LPLPHMGWNR
VYPQAGNRLF QGIEDGAYFY FVHSYAMPVN PWTIAQCNYG EPFTAAVQKD NFYGVQFHPE
RSGAAGAKLL KNFLEM
Length

196

Mol. Wt

21.652 kDa

pI

5.3 (calculated)

Extinction coefficient

21,430 - 21,930 (calc based on 7 Y, 2 W, and 4 C residues)


Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type Residues Description Notes References

Domain

4..196

PF00117 Glutamine amidotransferase class-I

PMID:19920124[6]

<motif_map/>

Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=hisH taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

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</protect>

Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type Source Notes/Reference

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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

NCBI (Protein) (EcoliWiki Page)

GI:16129964

Escherichia coli str. K-12 substr. MG1655

NCBI (Protein) (EcoliWiki Page)

GeneID:946544

Escherichia coli str. K-12 substr. MG1655

ASAP

ASAP:ABE-0006722

Escherichia coli str. K-12 substr. MG1655

UniProt (EcoliWiki Page)

UniProtKB/Swiss-Prot:P60595

Escherichia coli str. K-12 substr. MG1655

EcoCyc

EcoCyc:EG10450

Escherichia coli str. K-12 substr. MG1655

EcoGene

EcoGene:EG10450

Escherichia coli str. K-12 substr. MG1655

NCBI (Gene) (EcoliWiki Page)

GeneID:946544

Escherichia coli str. K-12 substr. MG1655

RegulonDB

RegulonDB:ECK120000443

Escherichia coli str. K-12 substr. MG1655

EchoBASE

EchoBASE:EB0445

Escherichia coli str. K-12 substr. MG1655

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Notes

Links

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References

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See Help:References for how to manage references in EcoliWiki.

  1. 1.0 1.1 1.2 1.3 1.4 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. 2.0 2.1 2.2 2.3 2.4 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. 3.0 3.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  5. Arifuzzaman, M et al. (2006) Large-scale identification of protein-protein interaction of Escherichia coli K-12. Genome Res. 16 686-91 PubMed
  6. Finn, RD et al. (2010) The Pfam protein families database. Nucleic Acids Res. 38 D211-22 PubMed

Categories

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