hisB:Gene Product(s)

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Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

HisB

Synonyms

fused histidinol-phosphatase[1], imidazoleglycerol-phosphate dehydratase[1], B2022[2][1], HisB[2][1] , ECK2017, JW2004, b2022

Product description

imidazole-phosphate dehydratase-histidinol phosphatase[2]; IMIDPHOSPHADEHYDHISTIDPHOSPHA[3];

Component of IMIDHISTID-CPLX[2]

Imidazoleglycerolphosphate dehydratase/histidinol phosphatase; bifunctional enzyme; HAD21[4]

EC number (for enzymes)

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Notes

Function

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<protect> Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000105

histidine biosynthetic process

GOA:hamap
GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_01022

P

Seeded from EcoCyc (v14.0)

complete

GO:0000105

histidine biosynthetic process

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000807

P

Seeded from EcoCyc (v14.0)

complete

GO:0000105

histidine biosynthetic process

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR005954

P

Seeded from EcoCyc (v14.0)

complete

GO:0000105

histidine biosynthetic process

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR006543

P

Seeded from EcoCyc (v14.0)

complete

GO:0000105

histidine biosynthetic process

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR020565

P

Seeded from EcoCyc (v14.0)

complete

GO:0000105

histidine biosynthetic process

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR020566

P

Seeded from EcoCyc (v14.0)

complete

GO:0000105

histidine biosynthetic process

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0368

P

Seeded from EcoCyc (v14.0)

complete

GO:0004401

histidinol-phosphatase activity

GOA:hamap
GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_01022

F

Seeded from EcoCyc (v14.0)

complete

GO:0004401

histidinol-phosphatase activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR005954

F

Seeded from EcoCyc (v14.0)

complete

GO:0004401

histidinol-phosphatase activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR006543

F

Seeded from EcoCyc (v14.0)

complete

GO:0004401

histidinol-phosphatase activity

GOA:spec
GO_REF:0000003

IEA: Inferred from Electronic Annotation

EC:3.1.3.15

F

Seeded from EcoCyc (v14.0)

complete

GO:0004424

imidazoleglycerol-phosphate dehydratase activity

GOA:hamap
GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_01022

F

Seeded from EcoCyc (v14.0)

complete

GO:0004424

imidazoleglycerol-phosphate dehydratase activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000807

F

Seeded from EcoCyc (v14.0)

complete

GO:0004424

imidazoleglycerol-phosphate dehydratase activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR005954

F

Seeded from EcoCyc (v14.0)

complete

GO:0004424

imidazoleglycerol-phosphate dehydratase activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR020565

F

Seeded from EcoCyc (v14.0)

complete

GO:0004424

imidazoleglycerol-phosphate dehydratase activity

GOA:spec
GO_REF:0000003

IEA: Inferred from Electronic Annotation

EC:4.2.1.19

F

Seeded from EcoCyc (v14.0)

complete

GO:0005737

cytoplasm

GOA:hamap
GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_01022

C

Seeded from EcoCyc (v14.0)

complete

GO:0005737

cytoplasm

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR005954

C

Seeded from EcoCyc (v14.0)

complete

GO:0005737

cytoplasm

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0963

C

Seeded from EcoCyc (v14.0)

complete

GO:0005737

cytoplasm

GO_REF:0000023

IEA: Inferred from Electronic Annotation

SP_SL:SL-0086

C

Seeded from EcoCyc (v14.0)

complete

Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type Partner Notes References Evidence

Protein

Subunits of IMIDHISTID-CPLX

could be indirect

Protein

helD

PMID:16606699[5]

Experiment(s):EBI-1141650

Protein

gltB

PMID:16606699[5]

Experiment(s):EBI-1141650

</protect>

Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment Description Evidence Reference/Source Notes

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Notes

Structure and Physical Properties

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<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence

at EcoCyc

MMSQKYLFID RDGTLISEPP SDFQVDRFDK LAFEPGVIPE LLKLQKAGYK LVMITNQDGL
GTQSFPQADF DGPHNLMMQI FTSQGVQFDE VLICPHLPAD ECDCRKPKVK LVERYLAEQA
MDRANSYVIG DRATDIQLAE NMGITGLRYD RETLNWPMIG EQLTRRDRYA HVVRNTKETQ
IDVQVWLDRE GGSKINTGVG FFDHMLDQIA THGGFRMEIN VKGDLYIDDH HTVEDTGLAL
GEALKIALGD KRGICRFGFV LPMDECLARC ALDISGRPHL EYKAEFTYQR VGDLSTEMIE
HFFRSLSYTM GVTLHLKTKG KNDHHRVESL FKAFGRTLRQ AIRVEGDTLP SSKGVL
Length

356

Mol. Wt

40.409 kDa

pI

6.1 (calculated)

Extinction coefficient

25,900 - 26,650 (calc based on 10 Y, 2 W, and 6 C residues)


Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type Residues Description Notes References

Domain

196..338

PF00475 Imidazoleglycerol-phosphate dehydratase

PMID:19920124[6]

Domain

4..183

PF08645 Polynucleotide kinase 3 phosphatase

PMID:19920124[6]

<motif_map/>

Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=hisB taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

<protect>

</protect>

Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type Source Notes/Reference

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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

NCBI (Protein) (EcoliWiki Page)

GI:90111373

Escherichia coli str. K-12 substr. MG1655

NCBI (Protein) (EcoliWiki Page)

GeneID:946552

Escherichia coli str. K-12 substr. MG1655

ASAP

ASAP:ABE-0006720

Escherichia coli str. K-12 substr. MG1655

UniProt (EcoliWiki Page)

UniProtKB/Swiss-Prot:P06987

Escherichia coli str. K-12 substr. MG1655

EcoCyc

EcoCyc:EG10445

Escherichia coli str. K-12 substr. MG1655

EcoGene

EcoGene:EG10445

Escherichia coli str. K-12 substr. MG1655

NCBI (Gene) (EcoliWiki Page)

GeneID:946552

Escherichia coli str. K-12 substr. MG1655

RegulonDB

RegulonDB:ECK120000438

Escherichia coli str. K-12 substr. MG1655

EchoBASE

EchoBASE:EB0440

Escherichia coli str. K-12 substr. MG1655

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Notes

Links

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References

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See Help:References for how to manage references in EcoliWiki.

  1. 1.0 1.1 1.2 1.3 1.4 1.5 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. 2.0 2.1 2.2 2.3 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  5. 5.0 5.1 Arifuzzaman, M et al. (2006) Large-scale identification of protein-protein interaction of Escherichia coli K-12. Genome Res. 16 686-91 PubMed
  6. 6.0 6.1 Finn, RD et al. (2010) The Pfam protein families database. Nucleic Acids Res. 38 D211-22 PubMed

Categories

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