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Comments (originally from EcoCyc[1][2]) The hisB gene encodes a bifunctional enzyme that catalyzes the sixth and eighth steps of histidine biosynthesis, encompassing two enzyme activities: histidinol phosphate phosphatase and imidazoleglycerol-phosphate dehydratase [3][4][5][6][7][8][9][10][11][10].


  1. EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  2. EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. Chiariotti, L et al. (1986) Gene structure in the histidine operon of Escherichia coli. Identification and nucleotide sequence of the hisB gene. Mol. Gen. Genet. 202 42-7 PubMed
  4. Brilli, M & Fani, R (2004) Molecular evolution of hisB genes. J. Mol. Evol. 58 225-37 PubMed
  5. LOPER, JC (1961) Enzyme complementation in mixed extracts of mutants from the Salmonella histidine B locus. Proc. Natl. Acad. Sci. U.S.A. 47 1440-50 PubMed
  6. Brady, DR & Houston, LL (1973) Some properties of the catalytic sites of imidazoleglycerol phosphate dehydratase-histidinol phosphate phosphatase, a bifunctional enzyme from Salmonella typhimurium. J. Biol. Chem. 248 2588-92 PubMed
  7. Houston, LL & Graham, ME (1974) Divalent metal ion effects on a mutant histidinol phosphate phosphatase from Salmonella typhimurium. Arch. Biochem. Biophys. 162 513-22 PubMed
  8. Chumley, FG & Roth, JR (1981) Genetic fusions that place the lactose genes under histidine operon control. J. Mol. Biol. 145 697-712 PubMed
  9. Kuznetsova, E et al. (2006) Genome-wide analysis of substrate specificities of the Escherichia coli haloacid dehalogenase-like phosphatase family. J. Biol. Chem. 281 36149-61 PubMed
  10. 10.0 10.1 Rangarajan, ES et al. (2006) Structural snapshots of Escherichia coli histidinol phosphate phosphatase along the reaction pathway. J. Biol. Chem. 281 37930-41 PubMed
  11. Lasserre, JP et al. (2006) A complexomic study of Escherichia coli using two-dimensional blue native/SDS polyacrylamide gel electrophoresis. Electrophoresis 27 3306-21 PubMed

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