grpE:Gene Product(s)

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Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

GrpE

Synonyms

heat shock protein[1], B2614[2][1], GrpE[2][1] , ECK2610, JW2594, b2614

Product description

phage lambda replication; host DNA synthesis; heat shock protein; protein repair[2][3];

Component of DnaJ/DnaK/GrpE[2][3]

Nucleotide exchange factor for the DnaKJ chaperone; heat shock protein; mutant survives lambda induction; stimulates DnaK and HscC ATPase[4]

EC number (for enzymes)


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Notes

Function

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<protect> Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000774

adenyl-nucleotide exchange factor activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000740

F

Seeded from EcoCyc (v14.0)

complete

GO:0005515

protein binding

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR009012

F

Seeded from EcoCyc (v14.0)

complete

GO:0005515

protein binding

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR013805

F

Seeded from EcoCyc (v14.0)

complete

GO:0005737

cytoplasm

GOA:hamap
GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_01151

C

Seeded from EcoCyc (v14.0)

complete

GO:0005737

cytoplasm

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0963

C

Seeded from EcoCyc (v14.0)

complete

GO:0005737

cytoplasm

GO_REF:0000023

IEA: Inferred from Electronic Annotation

SP_SL:SL-0086

C

Seeded from EcoCyc (v14.0)

complete

GO:0005739

mitochondrion

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000740

C

Seeded from EcoCyc (v14.0)

complete

GO:0006457

protein folding

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000740

P

Seeded from EcoCyc (v14.0)

complete

GO:0006457

protein folding

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR009012

P

Seeded from EcoCyc (v14.0)

complete

GO:0006950

response to stress

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0346

P

Seeded from EcoCyc (v14.0)

complete

GO:0009408

response to heat

PMID:8349564[5]

IEP: Inferred from Expression Pattern

P

complete

GO:0030150

protein import into mitochondrial matrix

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000740

P

Seeded from EcoCyc (v14.0)

complete

GO:0042803

protein homodimerization activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000740

F

Seeded from EcoCyc (v14.0)

complete

GO:0051087

chaperone binding

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000740

F

Seeded from EcoCyc (v14.0)

complete

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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type Partner Notes References Evidence

Protein

Subunits of DnaJ/DnaK/GrpE

could be indirect

Protein

gadA

PMID:15690043[6]

Experiment(s):EBI-881166

Protein

metK

PMID:15690043[6]

Experiment(s):EBI-881166

Protein

mntH

PMID:15690043[6]

Experiment(s):EBI-888219

Protein

ccmB

PMID:15690043[6]

Experiment(s):EBI-888219

Protein

dsdX

PMID:15690043[6]

Experiment(s):EBI-888219

Protein

emrY

PMID:15690043[6]

Experiment(s):EBI-888219

Protein

evgA

PMID:15690043[6]

Experiment(s):EBI-888219

Protein

flgK

PMID:15690043[6]

Experiment(s):EBI-888219

Protein

gadB

PMID:15690043[6]

Experiment(s):EBI-888219

Protein

rplD

PMID:15690043[6]

Experiment(s):EBI-888219

Protein

rplL

PMID:15690043[6]

Experiment(s):EBI-888219

Protein

rplS

PMID:15690043[6]

Experiment(s):EBI-888219

Protein

rpmG

PMID:15690043[6]

Experiment(s):EBI-888219

Protein

rpsB

PMID:15690043[6]

Experiment(s):EBI-888219

Protein

rpsG

PMID:15690043[6]

Experiment(s):EBI-888219

Protein

sra

PMID:15690043[6]

Experiment(s):EBI-888219

Protein

thiG

PMID:15690043[6]

Experiment(s):EBI-888219

Protein

tufA

PMID:15690043[6]

Experiment(s):EBI-888219

Protein

entB

PMID:15690043[6]

Experiment(s):EBI-888219

Protein

greA

PMID:16606699[7]

Experiment(s):EBI-1143469

Protein

paaB

PMID:16606699[7]

Experiment(s):EBI-1143469

Protein

rplO

PMID:16606699[7]

Experiment(s):EBI-1143469

Protein

zntR

PMID:16606699[7]

Experiment(s):EBI-1143469

Protein

rplN

PMID:16606699[7]

Experiment(s):EBI-1143469

Protein

phnN

PMID:16606699[7]

Experiment(s):EBI-1143469

Protein

ubiX

PMID:16606699[7]

Experiment(s):EBI-1143469

Protein

nusG

PMID:16606699[7]

Experiment(s):EBI-1143469

Protein

clpB

PMID:16606699[7]

Experiment(s):EBI-1143469

Protein

rplQ

PMID:16606699[7]

Experiment(s):EBI-1143469

Protein

rplS

PMID:16606699[7]

Experiment(s):EBI-1143469

Protein

tauB

PMID:16606699[7]

Experiment(s):EBI-1143469

Protein

rpsE

PMID:16606699[7]

Experiment(s):EBI-1143469

Protein

rpsI

PMID:16606699[7]

Experiment(s):EBI-1143469

Protein

fur

PMID:16606699[7]

Experiment(s):EBI-1143469

Protein

dnaK

PMID:16606699[7]

Experiment(s):EBI-1143469

Protein

ykgF

PMID:16606699[7]

Experiment(s):EBI-1143469

Protein

rho

PMID:16606699[7]

Experiment(s):EBI-1143469

Protein

nadE

PMID:16606699[7]

Experiment(s):EBI-1143469

Protein

torZ

PMID:16606699[7]

Experiment(s):EBI-1143469

Protein

matC

PMID:16606699[7]

Experiment(s):EBI-1143469

Protein

rplJ

PMID:16606699[7]

Experiment(s):EBI-1143469

Protein

pepD

PMID:16606699[7]

Experiment(s):EBI-1143469

Protein

lon

PMID:16606699[7]

Experiment(s):EBI-1143469

Protein

gadB

PMID:19402753[8]

LCMS(ID Probability):99.0 MALDI(Z-score):7.662561

Protein

thiG

PMID:19402753[8]

LCMS(ID Probability):99.0

Protein

emrY

PMID:19402753[8]

LCMS(ID Probability):99.0

Protein

mntH

PMID:19402753[8]

LCMS(ID Probability):99.0

Protein

dsdX

PMID:19402753[8]

LCMS(ID Probability):99.0

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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment Description Evidence Reference/Source Notes
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Notes

Structure and Physical Properties

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<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence

at EcoCyc 

MSSKEQKTPE GQAPEEIIMD QHEEIEAVEP EASAEQVDPR DEKVANLEAQ LAEAQTRERD
GILRVKAEME NLRRRTELDI EKAHKFALEK FINELLPVID SLDRALEVAD KANPDMSAMV
EGIELTLKSM LDVVRKFGVE VIAETNVPLD PNVHQAIAMV ESDDVAPGNV LGIMQKGYTL
NGRTIRAAMV TVAKAKA
Length

197

Mol. Wt

21.797 kDa

pI

4.6 (calculated)

Extinction coefficient

1,490 (calc based on 1 Y, 0 W, and 0 C residues)

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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type Residues Description Notes References

Domain

7..194

PF01025 GrpE

PMID:19920124[9]

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<motif_map/>

Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=grpE taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

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Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type Source Notes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

NCBI (Protein) (EcoliWiki Page)

GI:16130533

Escherichia coli str. K-12 substr. MG1655

NCBI (Protein) (EcoliWiki Page)

GeneID:947097

Escherichia coli str. K-12 substr. MG1655

ASAP

ASAP:ABE-0008598

Escherichia coli str. K-12 substr. MG1655

UniProt (EcoliWiki Page)

UniProtKB/Swiss-Prot:P09372

Escherichia coli str. K-12 substr. MG1655

EcoCyc

EcoCyc:EG10416

Escherichia coli str. K-12 substr. MG1655

EcoGene

EcoGene:EG10416

Escherichia coli str. K-12 substr. MG1655

NCBI (Gene) (EcoliWiki Page)

GeneID:947097

Escherichia coli str. K-12 substr. MG1655

RegulonDB

RegulonDB:ECK120000409

Escherichia coli str. K-12 substr. MG1655

EchoBASE

EchoBASE:EB0411

Escherichia coli str. K-12 substr. MG1655

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Notes

Links

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References

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See Help:References for how to manage references in EcoliWiki.

  1. ↑ 1.0 1.1 1.2 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ 3.0 3.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  5. ↑ Chuang, SE & Blattner, FR (1993) Characterization of twenty-six new heat shock genes of Escherichia coli. J. Bacteriol. 175 5242-52 PubMed
  6. ↑ 6.00 6.01 6.02 6.03 6.04 6.05 6.06 6.07 6.08 6.09 6.10 6.11 6.12 6.13 6.14 6.15 6.16 6.17 6.18 Butland, G et al. (2005) Interaction network containing conserved and essential protein complexes in Escherichia coli. Nature 433 531-7 PubMed
  7. ↑ 7.00 7.01 7.02 7.03 7.04 7.05 7.06 7.07 7.08 7.09 7.10 7.11 7.12 7.13 7.14 7.15 7.16 7.17 7.18 7.19 7.20 7.21 7.22 7.23 Arifuzzaman, M et al. (2006) Large-scale identification of protein-protein interaction of Escherichia coli K-12. Genome Res. 16 686-91 PubMed
  8. ↑ 8.0 8.1 8.2 8.3 8.4 Hu, P et al. (2009) Global functional atlas of Escherichia coli encompassing previously uncharacterized proteins. PLoS Biol. 7 e96 PubMed
  9. ↑ Finn, RD et al. (2010) The Pfam protein families database. Nucleic Acids Res. 38 D211-22 PubMed

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