fpr:Gene Product(s)

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Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

Fpr

Synonyms

ferredoxin-NADP reductase[1], B3924[2][1], FlxR[2][1], MvrA[2][1], Fpr[2][1] , ECK3916, flxR, JW3895, b3924

Product description

FLAVONADPREDUCT[2][3];

Component of anaerobic nucleoside-triphosphate reductase activating system[2][3]

Ferredoxin NADP+ reductase; anaerobic; cloned fpr gene suppresses unlinked mvrA mutation[4]

EC number (for enzymes)
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Notes

Function

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<protect> Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0005737

cytoplasm

C

Seeded from Riley et al 2006 [1].

Missing: evidence, reference

GO:0042493

response to drug

PMID:2834327[5]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0004324

ferredoxin-NADP+ reductase activity

GOA:spec
GO_REF:0000003

IEA: Inferred from Electronic Annotation

EC:1.18.1.2

F

Seeded from EcoCyc (v14.0)

complete

GO:0055114

oxidation reduction

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001433

P

Seeded from EcoCyc (v14.0)

complete

GO:0055114

oxidation reduction

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR008333

P

Seeded from EcoCyc (v14.0)

complete

GO:0055114

oxidation reduction

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR017927

P

Seeded from EcoCyc (v14.0)

complete

GO:0055114

oxidation reduction

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0560

P

Seeded from EcoCyc (v14.0)

complete

GO:0004324

ferredoxin-NADP+ reductase activity

PMID:7042345[6]

IDA: Inferred from Direct Assay

F

from EcoCyc_v23.0

complete

GO:0004324

ferredoxin-NADP+ reductase activity

PMID:8449868[7]

IDA: Inferred from Direct Assay

F

from EcoCyc_v23.0

complete

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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type Partner Notes References Evidence

Protein

Subunits of anaerobic nucleoside-triphosphate reductase activating system

could be indirect

Protein

deoC

PMID:16606699[8]

Experiment(s):EBI-1147065

Protein

rpsD

PMID:16606699[8]

Experiment(s):EBI-1147065

Protein

nadE

PMID:16606699[8]

Experiment(s):EBI-1147065

Protein

blc

PMID:16606699[8]

Experiment(s):EBI-1147065
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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment Description Evidence Reference/Source Notes
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Notes

Structure and Physical Properties

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<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence

at EcoCyc 

MADWVTGKVT KVQNWTDALF SLTVHAPVLP FTAGQFTKLG LEIDGERVQR AYSYVNSPDN
PDLEFYLVTV PDGKLSPRLA ALKPGDEVQV VSEAAGFFVL DEVPHCETLW MLATGTAIGP
YLSILQLGKD LDRFKNLVLV HAARYAADLS YLPLMQELEK RYEGKLRIQT VVSRETAAGS
LTGRIPALIE SGELESTIGL PMNKETSHVM LCGNPQMVRD TQQLLKETRQ MTKHLRRRPG
HMTAEHYW
Length

248

Mol. Wt

27.75 kDa

pI

6.6 (calculated)

Extinction coefficient

33,920 - 34,170 (calc based on 8 Y, 4 W, and 2 C residues)

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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type Residues Description Notes References

Initiator Methionine

1

Removed

UniProt:P28861

Domain

6..98

PF00970 Oxidoreductase FAD-binding domain

PMID:19920124[9]

Domain

111..223

PF00175 Oxidoreductase NAD-binding domain

PMID:19920124[9]

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Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=fpr taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

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Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type Source Notes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

NCBI (Protein) (EcoliWiki Page)

GI:16131762

Escherichia coli str. K-12 substr. MG1655

NCBI (Protein) (EcoliWiki Page)

GeneID:948414

Escherichia coli str. K-12 substr. MG1655

ASAP

ASAP:ABE-0012818

Escherichia coli str. K-12 substr. MG1655

UniProt (EcoliWiki Page)

UniProtKB/Swiss-Prot:P28861

Escherichia coli str. K-12 substr. MG1655

EcoCyc

EcoCyc:EG10628

Escherichia coli str. K-12 substr. MG1655

EcoGene

EcoGene:EG10628

Escherichia coli str. K-12 substr. MG1655

NCBI (Gene) (EcoliWiki Page)

GeneID:948414

Escherichia coli str. K-12 substr. MG1655

RegulonDB

RegulonDB:ECK120000621

Escherichia coli str. K-12 substr. MG1655

EchoBASE

EchoBASE:EB1480

Escherichia coli str. K-12 substr. MG1655

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Notes

Links

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References

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See Help:References for how to manage references in EcoliWiki.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 2.4 2.5 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ 3.0 3.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  5. ↑ Morimyo, M (1988) Isolation and characterization of methyl viologen-sensitive mutants of Escherichia coli K-12. J. Bacteriol. 170 2136-42 PubMed
  6. ↑ Blaschkowski, HP et al. (1982) Routes of flavodoxin and ferredoxin reduction in Escherichia coli. CoA-acylating pyruvate: flavodoxin and NADPH: flavodoxin oxidoreductases participating in the activation of pyruvate formate-lyase. Eur. J. Biochem. 123 563-9 PubMed
  7. ↑ Bianchi, V et al. (1993) Escherichia coli ferredoxin NADP+ reductase: activation of E. coli anaerobic ribonucleotide reduction, cloning of the gene (fpr), and overexpression of the protein. J. Bacteriol. 175 1590-5 PubMed
  8. ↑ 8.0 8.1 8.2 8.3 Arifuzzaman, M et al. (2006) Large-scale identification of protein-protein interaction of Escherichia coli K-12. Genome Res. 16 686-91 PubMed
  9. ↑ 9.0 9.1 Finn, RD et al. (2010) The Pfam protein families database. Nucleic Acids Res. 38 D211-22 PubMed

Categories

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