fkpA:Gene Product(s)

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Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

FkpA

Synonyms

FKBP-type peptidyl-prolyl cis-trans isomerase (rotamase)[1], B3347[2][1], YzzS[2][1], FkpA[2][1] , ECK3334, JW3309, yzzS, b3347

Product description

peptidyl-prolyl cis-trans isomerase; in protein folding[2][3]

Periplasmic peptidylprolyl cis,trans isomerase; heat shock inducible; PPIase-independent chaperone activity, binds FK506[4]

EC number (for enzymes)
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Notes

Function

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<protect> Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0030288

outer membrane-bounded periplasmic space

C

Seeded from Riley et al 2006 [1].

Missing: evidence, reference

GO:0003755

peptidyl-prolyl cis-trans isomerase activity

GOA:spec
GO_REF:0000003

IEA: Inferred from Electronic Annotation

EC:5.2.1.8

F

Seeded from EcoCyc (v14.0)

complete

GO:0003755

peptidyl-prolyl cis-trans isomerase activity

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0697

F

Seeded from EcoCyc (v14.0)

complete

GO:0006457

protein folding

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000774

P

Seeded from EcoCyc (v14.0)

complete

GO:0005515

protein binding

PMID:18554332[5]

IPI: Inferred from Physical Interaction

UniProtKB:P05820


F

complete

GO:0006457

protein folding

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001179

P

Seeded from EcoCyc (v14.0)

complete

GO:0042026

protein refolding

PMID:18554332[5]

IDA: Inferred from Direct Assay

P

complete

GO:0006457

protein folding

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0697

P

Seeded from EcoCyc (v14.0)

complete

GO:0016853

isomerase activity

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0413

F

Seeded from EcoCyc (v14.0)

complete

GO:0042597

periplasmic space

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0574

C

Seeded from EcoCyc (v14.0)

complete

GO:0042597

periplasmic space

GO_REF:0000023

IEA: Inferred from Electronic Annotation

SP_SL:SL-0200

C

Seeded from EcoCyc (v14.0)

complete

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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type Partner Notes References Evidence

Protein

yeiT

PMID:15690043[6]

Experiment(s):EBI-893366

Protein

carA

PMID:15690043[6]

Experiment(s):EBI-893366

Protein

entE

PMID:15690043[6]

Experiment(s):EBI-893366

Protein

lsrK

PMID:15690043[6]

Experiment(s):EBI-893366

Protein

ypdC

PMID:16606699[7]

Experiment(s):EBI-1145628

Protein

ulaR

PMID:16606699[7]

Experiment(s):EBI-1145628

Protein

minD

PMID:16606699[7]

Experiment(s):EBI-1145628

Protein

ydhT

PMID:16606699[7]

Experiment(s):EBI-1145628

Protein

lpxB

PMID:16606699[7]

Experiment(s):EBI-1145628

Protein

sxy

PMID:16606699[7]

Experiment(s):EBI-1145628

Protein

ygdL

PMID:16606699[7]

Experiment(s):EBI-1145628

Protein

xseA

PMID:16606699[7]

Experiment(s):EBI-1145628

Protein

rpsD

PMID:16606699[7]

Experiment(s):EBI-1145628

Protein

carA

PMID:19402753[8]

LCMS(ID Probability):99.0

Protein

entE

PMID:19402753[8]

LCMS(ID Probability):99.0

Protein

lsrK

PMID:19402753[8]

LCMS(ID Probability):99.0

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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment Description Evidence Reference/Source Notes

periplasm

From EcoCyc[3]

Periplasm

PMID:9298646[9]

EchoLocation:fkpA


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Notes

Structure and Physical Properties

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<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence

at EcoCyc 

MKSLFKVTLL ATTMAVALHA PITFAAEAAK PATAADSKAA FKNDDQKSAY ALGASLGRYM
ENSLKEQEKL GIKLDKDQLI AGVQDAFADK SKLSDQEIEQ TLQAFEARVK SSAQAKMEKD
AADNEAKGKE YREKFAKEKG VKTSSTGLVY QVVEAGKGEA PKDSDTVVVN YKGTLIDGKE
FDNSYTRGEP LSFRLDGVIP GWTEGLKNIK KGGKIKLVIP PELAYGKAGV PGIPPNSTLV
FDVELLDVKP APKADAKPEA DAKAADSAKK
Length

270

Mol. Wt

28.882 kDa

pI

8.8 (calculated)

Extinction coefficient

15,930 (calc based on 7 Y, 1 W, and 0 C residues)

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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type Residues Description Notes References

motif

1-25

UniProt Manual:Signal Peptides

UniProt:P45523

Domain

156..246

PF00254 FKBP-type peptidyl-prolyl cis-trans isomerase

PMID:19920124[10]

Domain

23..152

PF01346 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase

PMID:19920124[10]

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Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=fkpA taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

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Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type Source Notes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

NCBI (Protein) (EcoliWiki Page)

GI:16131226

Escherichia coli str. K-12 substr. MG1655

NCBI (Protein) (EcoliWiki Page)

GeneID:947850

Escherichia coli str. K-12 substr. MG1655

ASAP

ASAP:ABE-0010938

Escherichia coli str. K-12 substr. MG1655

UniProt (EcoliWiki Page)

UniProtKB/Swiss-Prot:P45523

Escherichia coli str. K-12 substr. MG1655

EcoCyc

EcoCyc:G7716

Escherichia coli str. K-12 substr. MG1655

EcoGene

EcoGene:EG12900

Escherichia coli str. K-12 substr. MG1655

NCBI (Gene) (EcoliWiki Page)

GeneID:947850

Escherichia coli str. K-12 substr. MG1655

RegulonDB

RegulonDB:ECK120004261

Escherichia coli str. K-12 substr. MG1655

EchoBASE

EchoBASE:EB2737

Escherichia coli str. K-12 substr. MG1655

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Notes

Links

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References

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See Help:References for how to manage references in EcoliWiki.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ 3.0 3.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  5. ↑ 5.0 5.1 Hullmann, J et al. (2008) Periplasmic chaperone FkpA is essential for imported colicin M toxicity. Mol. Microbiol. 69 926-37 PubMed
  6. ↑ 6.0 6.1 6.2 6.3 Butland, G et al. (2005) Interaction network containing conserved and essential protein complexes in Escherichia coli. Nature 433 531-7 PubMed
  7. ↑ 7.0 7.1 7.2 7.3 7.4 7.5 7.6 7.7 7.8 Arifuzzaman, M et al. (2006) Large-scale identification of protein-protein interaction of Escherichia coli K-12. Genome Res. 16 686-91 PubMed
  8. ↑ 8.0 8.1 8.2 Hu, P et al. (2009) Global functional atlas of Escherichia coli encompassing previously uncharacterized proteins. PLoS Biol. 7 e96 PubMed
  9. ↑ Link, AJ et al. (1997) Comparing the predicted and observed properties of proteins encoded in the genome of Escherichia coli K-12. Electrophoresis 18 1259-313 PubMed
  10. ↑ 10.0 10.1 Finn, RD et al. (2010) The Pfam protein families database. Nucleic Acids Res. 38 D211-22 PubMed

Categories

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