fklB:Gene Product(s)

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Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

FklB

Synonyms

FKBP-type peptidyl-prolyl cis-trans isomerase (rotamase)[1], B4207[2][1], YtfC[2][1], FklB[2][1], FKBP22[2][1] , ECK4203, JW5746, ytfC, b4207

Product description

FKBP-type peptidyl-prolyl cis-trans isomerase (rotamase)[2][3];

Component of FKBP-type peptidyl-prolyl cis-trans isomerase (rotamase)[3]

FKBP-type peptidyl-prolyl cis-trans isomerase; contains pipecolic acid residue[4]

EC number (for enzymes)
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Notes

Function

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<protect> Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0003755

peptidyl-prolyl cis-trans isomerase activity

GOA:spec
GO_REF:0000003

IEA: Inferred from Electronic Annotation

EC:5.2.1.8

F

Seeded from EcoCyc (v14.0)

complete

GO:0003755

peptidyl-prolyl cis-trans isomerase activity

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0697

F

Seeded from EcoCyc (v14.0)

complete

GO:0005829

cytosol

PMID:16858726[5]

IDA: Inferred from Direct Assay

C

Seeded from EcoCyc (v14.0)

complete

GO:0006457

protein folding

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000774

P

Seeded from EcoCyc (v14.0)

complete

GO:0006457

protein folding

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001179

P

Seeded from EcoCyc (v14.0)

complete

GO:0006457

protein folding

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0697

P

Seeded from EcoCyc (v14.0)

complete

GO:0016853

isomerase activity

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0413

F

Seeded from EcoCyc (v14.0)

complete

GO:0042597

periplasmic space

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0574

C

Seeded from EcoCyc (v14.0)

complete

GO:0042597

periplasmic space

GO_REF:0000023

IEA: Inferred from Electronic Annotation

SP_SL:SL-0200

C

Seeded from EcoCyc (v14.0)

complete

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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type Partner Notes References Evidence

Protein

Subunits of FKBP-type peptidyl-prolyl cis-trans isomerase (rotamase)

could be indirect

Protein

entB

PMID:15690043[6]

Experiment(s):EBI-883674

Protein

glpF

PMID:15690043[6]

Experiment(s):EBI-883674

Protein

proY

PMID:15690043[6]

Experiment(s):EBI-883674

Protein

trkH

PMID:15690043[6]

Experiment(s):EBI-883674

Protein

trkH

PMID:19402753[7]

LCMS(ID Probability):99.0

Protein

proY

PMID:19402753[7]

LCMS(ID Probability):99.0

Protein

glpF

PMID:19402753[7]

LCMS(ID Probability):99.0

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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment Description Evidence Reference/Source Notes
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Notes

Structure and Physical Properties

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<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence

at EcoCyc 

MMSVVNPPLL YSYGILLLFL FPWDLSSFPR QSFTQRSVAD MLPATLYPKK GNTMTTPTFD
TIEAQASYGI GLQVGQQLSE SGLEGLLPEA LVAGIADALE GKHPAVPVDV VHRALREIHE
RADAVRRQRF QAMAAEGVKY LEENAKKEGV NSTESGLQFR VINQGEGAIP ARTDRVRVHY
TGKLIDGTVF DSSVARGEPA EFPVNGVIPG WIEALTLMPV GSKWELTIPQ ELAYGERGAG
ASIPPFSTLV FEVELLEIL
Length

259

Mol. Wt

28.251 kDa

pI

4.9 (calculated)

Extinction coefficient

26,930 (calc based on 7 Y, 3 W, and 0 C residues)

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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type Residues Description Notes References

Initiator Methionine

1

Removed

UniProt:P0A9L3

Domain

112..203

PF00254 FKBP-type peptidyl-prolyl cis-trans isomerase

PMID:19920124[8]

Domain

1..108

PF01346 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase

PMID:19920124[8]

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Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=fklB taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

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Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type Source Notes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

NCBI (Protein) (EcoliWiki Page)

GI:90111705

Escherichia coli str. K-12 substr. MG1655

NCBI (Protein) (EcoliWiki Page)

GeneID:948726

Escherichia coli str. K-12 substr. MG1655

ASAP

ASAP:ABE-0013759

Escherichia coli str. K-12 substr. MG1655

UniProt (EcoliWiki Page)

UniProtKB/Swiss-Prot:P0A9L3

Escherichia coli str. K-12 substr. MG1655

EcoCyc

EcoCyc:G7865

Escherichia coli str. K-12 substr. MG1655

EcoGene

EcoGene:EG12503

Escherichia coli str. K-12 substr. MG1655

NCBI (Gene) (EcoliWiki Page)

GeneID:948726

Escherichia coli str. K-12 substr. MG1655

RegulonDB

RegulonDB:ECK120004360

Escherichia coli str. K-12 substr. MG1655

EchoBASE

EchoBASE:EB2396

Escherichia coli str. K-12 substr. MG1655

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Notes

Links

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References

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See Help:References for how to manage references in EcoliWiki.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 2.4 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ 3.0 3.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  5. ↑ Lasserre, JP et al. (2006) A complexomic study of Escherichia coli using two-dimensional blue native/SDS polyacrylamide gel electrophoresis. Electrophoresis 27 3306-21 PubMed
  6. ↑ 6.0 6.1 6.2 6.3 Butland, G et al. (2005) Interaction network containing conserved and essential protein complexes in Escherichia coli. Nature 433 531-7 PubMed
  7. ↑ 7.0 7.1 7.2 Hu, P et al. (2009) Global functional atlas of Escherichia coli encompassing previously uncharacterized proteins. PLoS Biol. 7 e96 PubMed
  8. ↑ 8.0 8.1 Finn, RD et al. (2010) The Pfam protein families database. Nucleic Acids Res. 38 D211-22 PubMed

Categories

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