fhlA:Gene Product(s)

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Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

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Standard name

FhlA

Synonyms

DNA-binding transcriptional activator[1], Fhl[2][1], B2731[2][1], FhlA[2][1], formate hydrogen-lyase transcriptional activator for fdhF, hyc and hyp operons[2][1] , ECK2726, fhl, JW2701, b2731

Product description

FhlA transcriptional activator[2][3]

Formate hydrogen lyase system activator, global regulator[4]

EC number (for enzymes)


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Notes

Function

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<protect> Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type Partner Notes References Evidence

Protein

groL

PMID:16606699[5]

Experiment(s):EBI-1143770

RNA

OxyS RNA

OxyS RNA represses translation of fhlA by encoding a transcriptional activator. This is important for survival against hydrogen peroxide.

PMID:11804582[6] PMID:9230301[7]


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Notes

Localization

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Compartment Description Evidence Reference/Source Notes
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Notes

Structure and Physical Properties

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<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence

at EcoCyc 

MSYTPMSDLG QQGLFDITRT LLQQPDLASL CEALSQLVKR SALADNAAIV LWQAQTQRAS
YYASREKDTP IKYEDETVLA HGPVRSILSR PDTLHCSYEE FCETWPQLDA GGLYPKFGHY
CLMPLAAEGH IFGGCEFIRY DDRPWSEKEF NRLQTFTQIV SVVTEQIQSR VVNNVDYELL
CRERDNFRIL VAITNAVLSR LDMDELVSEV AKEIHYYFDI DDISIVLRSH RKNKLNIYST
HYLDKQHPAH EQSEVDEAGT LTERVFKSKE MLLINLHERD DLAPYERMLF DTWGNQIQTL
CLLPLMSGDT MLGVLKLAQC EEKVFTTTNL NLLRQIAERV AIAVDNALAY QEIHRLKERL
VDENLALTEQ LNNVDSEFGE IIGRSEAMYS VLKQVEMVAQ SDSTVLILGE TGTGKELIAR
AIHNLSGRNN RRMVKMNCAA MPAGLLESDL FGHERGAFTG ASAQRIGRFE LADKSSLFLD
EVGDMPLELQ PKLLRVLQEQ EFERLGSNKI IQTDVRLIAA TNRDLKKMVA DREFRSDLYY
RLNVFPIHLP PLRERPEDIP LLAKAFTFKI ARRLGRNIDS IPAETLRTLS NMEWPGNVRE
LENVIERAVL LTRGNVLQLS LPDIVLPEPE TPPAATVVAL EGEDEYQLIV RVLKETNGVV
AGPKGAAQRL GLKRTTLLSR MKRLGIDKSA LI
Length

692

Mol. Wt

78.469 kDa

pI

5.4 (calculated)

Extinction coefficient

55,810 - 56,935 (calc based on 19 Y, 5 W, and 9 C residues)

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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type Residues Description Notes References

Domain

202..344

PF01590 GAF domain

PMID:19920124[8]

Domain

642..684

PF02954 Bacterial regulatory protein, Fis family

PMID:19920124[8]

Domain

381..548

PF00158 Sigma-54 interaction domain

PMID:19920124[8]

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Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=fhlA taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

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Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type Source Notes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

NCBI (Protein) (EcoliWiki Page)

GI:16130638

Escherichia coli str. K-12 substr. MG1655

NCBI (Protein) (EcoliWiki Page)

GeneID:947181

Escherichia coli str. K-12 substr. MG1655

ASAP

ASAP:ABE-0008971

Escherichia coli str. K-12 substr. MG1655

UniProt (EcoliWiki Page)

UniProtKB/Swiss-Prot:P19323

Escherichia coli str. K-12 substr. MG1655

EcoCyc

EcoCyc:EG10301

Escherichia coli str. K-12 substr. MG1655

EcoGene

EcoGene:EG10301

Escherichia coli str. K-12 substr. MG1655

NCBI (Gene) (EcoliWiki Page)

GeneID:947181

Escherichia coli str. K-12 substr. MG1655

RegulonDB

RegulonDB:ECK120000295

Escherichia coli str. K-12 substr. MG1655

EchoBASE

EchoBASE:EB0297

Escherichia coli str. K-12 substr. MG1655

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Notes

Links

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References

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See Help:References for how to manage references in EcoliWiki.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 2.4 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  5. ↑ Arifuzzaman, M et al. (2006) Large-scale identification of protein-protein interaction of Escherichia coli K-12. Genome Res. 16 686-91 PubMed
  6. ↑ Zhang, A et al. (2002) The Sm-like Hfq protein increases OxyS RNA interaction with target mRNAs. Mol. Cell 9 11-22 PubMed
  7. ↑ Altuvia, S et al. (1997) A small, stable RNA induced by oxidative stress: role as a pleiotropic regulator and antimutator. Cell 90 43-53 PubMed
  8. ↑ 8.0 8.1 8.2 Finn, RD et al. (2010) The Pfam protein families database. Nucleic Acids Res. 38 D211-22 PubMed

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