fabZ:Gene Product(s)

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Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

FabZ

Synonyms

(3R)-hydroxymyristol acyl carrier protein dehydratase[1], B0180[2][1], YaeA[2][1], SefA[2][1], FabZ[2][1] , ECK0179, JW0175, sabA, sefA, sfhC, yaeA, b0180

Product description

FabZ[2][3];

Component of FABZ-CPLX[2]

3R-hydroxymyristoyl acyl carrier protein (ACP) dehydratase[4]

EC number (for enzymes)
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Notes

Function

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<protect> Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0005737

cytoplasm

GOA:hamap
GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_00406

C

Seeded from EcoCyc (v14.0)

complete

GO:0005737

cytoplasm

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR010084

C

Seeded from EcoCyc (v14.0)

complete

GO:0005737

cytoplasm

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0963

C

Seeded from EcoCyc (v14.0)

complete

GO:0005737

cytoplasm

GO_REF:0000023

IEA: Inferred from Electronic Annotation

SP_SL:SL-0086

C

Seeded from EcoCyc (v14.0)

complete

GO:0006633

fatty acid biosynthetic process

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR010084

P

Seeded from EcoCyc (v14.0)

complete

GO:0008610

lipid biosynthetic process

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0444

P

Seeded from EcoCyc (v14.0)

complete

GO:0009245

lipid A biosynthetic process

GOA:hamap
GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_00406

P

Seeded from EcoCyc (v14.0)

complete

GO:0009245

lipid A biosynthetic process

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0441

P

Seeded from EcoCyc (v14.0)

complete

GO:0016829

lyase activity

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0456

F

Seeded from EcoCyc (v14.0)

complete

GO:0016836

hydro-lyase activity

GOA:hamap
GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_00406

F

Seeded from EcoCyc (v14.0)

complete

GO:0016836

hydro-lyase activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR010084

F

Seeded from EcoCyc (v14.0)

complete

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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type Partner Notes References Evidence

Protein

Subunits of FABZ-CPLX

could be indirect

Protein

clpA

PMID:15690043[5]

Experiment(s):EBI-887148

Protein

ffh

PMID:15690043[5]

Experiment(s):EBI-887148

Protein

glnS

PMID:15690043[5]

Experiment(s):EBI-887148

Protein

lon

PMID:15690043[5]

Experiment(s):EBI-887148

Protein

rplA

PMID:15690043[5]

Experiment(s):EBI-887148

Protein

rplB

PMID:15690043[5]

Experiment(s):EBI-887148

Protein

rplC

PMID:15690043[5]

Experiment(s):EBI-887148

Protein

rplD

PMID:15690043[5]

Experiment(s):EBI-887148

Protein

rplE

PMID:15690043[5]

Experiment(s):EBI-887148

Protein

rplF

PMID:15690043[5]

Experiment(s):EBI-887148

Protein

rplI

PMID:15690043[5]

Experiment(s):EBI-887148

Protein

rplJ

PMID:15690043[5]

Experiment(s):EBI-887148

Protein

rplM

PMID:15690043[5]

Experiment(s):EBI-887148

Protein

rplS

PMID:15690043[5]

Experiment(s):EBI-887148

Protein

rplV

PMID:15690043[5]

Experiment(s):EBI-887148

Protein

rpsA

PMID:15690043[5]

Experiment(s):EBI-887148

Protein

rpsB

PMID:15690043[5]

Experiment(s):EBI-887148

Protein

rpsC

PMID:15690043[5]

Experiment(s):EBI-887148

Protein

rpsD

PMID:15690043[5]

Experiment(s):EBI-887148

Protein

rpsE

PMID:15690043[5]

Experiment(s):EBI-887148

Protein

rpsG

PMID:15690043[5]

Experiment(s):EBI-887148

Protein

tufA

PMID:15690043[5]

Experiment(s):EBI-887148

Protein

gfcD

PMID:16606699[6]

Experiment(s):EBI-1135815

Protein

yjdA

PMID:16606699[6]

Experiment(s):EBI-1135815

Protein

rpsS

PMID:19402753[7]

LCMS(ID Probability):99.5

Protein

rpmB

PMID:19402753[7]

LCMS(ID Probability):99.6

Protein

rplE

PMID:19402753[7]

MALDI(Z-score):24.447798

Protein

rplB

PMID:19402753[7]

MALDI(Z-score):37.538291

Protein

rpsC

PMID:19402753[7]

MALDI(Z-score):21.542976

Protein

rpsA

PMID:19402753[7]

MALDI(Z-score):26.526817

Protein

rplA

PMID:19402753[7]

MALDI(Z-score):36.908339

Protein

rpsD

PMID:19402753[7]

MALDI(Z-score):34.031891

Protein

ffh

PMID:19402753[7]

MALDI(Z-score):17.979572

Protein

clpA

PMID:19402753[7]

MALDI(Z-score):22.261569

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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment Description Evidence Reference/Source Notes

Cytoplasm

PMID:8354462[8], PMID:7806516[9], PMID:8805534[10], PMID:8910376[11]

EchoLocation:fabZ


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Notes

Structure and Physical Properties

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<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence

at EcoCyc 

MTTNTHTLQI EEILELLPHR FPFLLVDRVL DFEEGRFLRA VKNVSVNEPF FQGHFPGKPI
FPGVLILEAM AQATGILAFK SVGKLEPGEL YYFAGIDEAR FKRPVVPGDQ MIMEVTFEKT
RRGLTRFKGV ALVDGKVVCE ATMMCARSRE A
Length

151

Mol. Wt

17.032 kDa

pI

7.2 (calculated)

Extinction coefficient

2,980 - 3,230 (calc based on 2 Y, 0 W, and 2 C residues)

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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type Residues Description Notes References

Domain

17..142

PF07977 FabA-like domain

PMID:19920124[12]

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Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=fabZ taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

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Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type Source Notes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

NCBI (Protein) (EcoliWiki Page)

GI:16128173

Escherichia coli str. K-12 substr. MG1655

NCBI (Protein) (EcoliWiki Page)

GeneID:944888

Escherichia coli str. K-12 substr. MG1655

ASAP

ASAP:ABE-0000613

Escherichia coli str. K-12 substr. MG1655

UniProt (EcoliWiki Page)

UniProtKB/Swiss-Prot:P0A6Q6

Escherichia coli str. K-12 substr. MG1655

EcoCyc

EcoCyc:EG11284

Escherichia coli str. K-12 substr. MG1655

EcoGene

EcoGene:EG11284

Escherichia coli str. K-12 substr. MG1655

NCBI (Gene) (EcoliWiki Page)

GeneID:944888

Escherichia coli str. K-12 substr. MG1655

RegulonDB

RegulonDB:ECK120001257

Escherichia coli str. K-12 substr. MG1655

EchoBASE

EchoBASE:EB1261

Escherichia coli str. K-12 substr. MG1655

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Notes

Links

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References

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See Help:References for how to manage references in EcoliWiki.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 2.4 2.5 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  5. ↑ 5.00 5.01 5.02 5.03 5.04 5.05 5.06 5.07 5.08 5.09 5.10 5.11 5.12 5.13 5.14 5.15 5.16 5.17 5.18 5.19 5.20 5.21 Butland, G et al. (2005) Interaction network containing conserved and essential protein complexes in Escherichia coli. Nature 433 531-7 PubMed
  6. ↑ 6.0 6.1 Arifuzzaman, M et al. (2006) Large-scale identification of protein-protein interaction of Escherichia coli K-12. Genome Res. 16 686-91 PubMed
  7. ↑ 7.0 7.1 7.2 7.3 7.4 7.5 7.6 7.7 7.8 7.9 Hu, P et al. (2009) Global functional atlas of Escherichia coli encompassing previously uncharacterized proteins. PLoS Biol. 7 e96 PubMed
  8. ↑ Foster, SJ (1993) Purification and characterization of an 'actomyosin' complex from Escherichia coli W3110. FEMS Microbiol. Lett. 110 295-8 PubMed
  9. ↑ Mohan, S et al. (1994) An Escherichia coli gene (FabZ) encoding (3R)-hydroxymyristoyl acyl carrier protein dehydrase. Relation to fabA and suppression of mutations in lipid A biosynthesis. J. Biol. Chem. 269 32896-903 PubMed
  10. ↑ Leesong, M et al. (1996) Structure of a dehydratase-isomerase from the bacterial pathway for biosynthesis of unsaturated fatty acids: two catalytic activities in one active site. Structure 4 253-64 PubMed
  11. ↑ Heath, RJ & Rock, CO (1996) Roles of the FabA and FabZ beta-hydroxyacyl-acyl carrier protein dehydratases in Escherichia coli fatty acid biosynthesis. J. Biol. Chem. 271 27795-801 PubMed
  12. ↑ Finn, RD et al. (2010) The Pfam protein families database. Nucleic Acids Res. 38 D211-22 PubMed

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