envR:Gene Product(s)

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Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

EnvR

Synonyms

DNA-binding transcriptional regulator[1], B3264[2][1], YhdK[2][1], AcrS[2][1], EnvR[2][1] , acrS, ECK3251, JW3232, yhdK, b3264

Product description

Putative transcriptional regulator[2][3]

Probable transcriptional repressor for acrEF (envCD); function unknown[4]

EC number (for enzymes)


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Notes

Function

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<protect> Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0003700

transcription factor activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001647

F

Seeded from EcoCyc (v14.0)

complete

GO:0003700

transcription factor activity

PMID:18567659[5]

IMP: Inferred from Mutant Phenotype

F

Seeded from EcoCyc (v14.0)

complete

GO:0003700

transcription factor activity

PMID:7592375[6]

ISS: Inferred from Sequence or Structural Similarity

Swiss-Prot:Q56153
Swiss-Prot:C0ITL5
Swiss-Prot:P0ACS9
Swiss-Prot:P28815
Swiss-Prot:P39885

F

Seeded from EcoCyc (v14.0)

complete

GO:0016566

specific transcriptional repressor activity

PMID:18567659[5]

IMP: Inferred from Mutant Phenotype

F

Seeded from EcoCyc (v14.0)

complete

GO:0016566

specific transcriptional repressor activity

PMID:7592375[6]

ISS: Inferred from Sequence or Structural Similarity

Swiss-Prot:Q56153
Swiss-Prot:C0ITL5
Swiss-Prot:P0ACS9
Swiss-Prot:P28815
Swiss-Prot:P39885

F

Seeded from EcoCyc (v14.0)

complete

GO:0032582

negative regulation of gene-specific transcription

PMID:18567659[5]

IMP: Inferred from Mutant Phenotype

P

Seeded from EcoCyc (v14.0)

complete

GO:0032582

negative regulation of gene-specific transcription

PMID:7592375[6]

ISS: Inferred from Sequence or Structural Similarity

Swiss-Prot:Q56153
Swiss-Prot:C0ITL5
Swiss-Prot:P0ACS9
Swiss-Prot:P28815
Swiss-Prot:P39885

P

Seeded from EcoCyc (v14.0)

complete

Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type Partner Notes References Evidence

Protein

puuD

PMID:16606699[7]

Experiment(s):EBI-1145339

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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment Description Evidence Reference/Source Notes

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Notes

Structure and Physical Properties

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<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence

at EcoCyc

MAKRTKAEAL KTRQELIETA IAQFAQHGVS KTTLNDIADA ANVTRGAIYW HFENKTQLFN
EMWLQQPSLR ELIQEHLTAG LEHDPFQQLR EKLIVGLQYI AKIPRQQALL KILYHKCEFN
DEMLAEGVIR EKMGFNPQTL REVLQACQQQ GCVANNLDLD VVMIIIDGAF SGIVQNWLMN
MAGYDLYKQA PALVDNVLRM FMPDENITKL IHQTNELSVM
Length

220

Mol. Wt

25.198 kDa

pI

6.0 (calculated)

Extinction coefficient

23,950 - 24,325 (calc based on 5 Y, 3 W, and 3 C residues)


Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type Residues Description Notes References

Domain

16..62

PF00440 Bacterial regulatory proteins, tetR family

PMID:19920124[8]

Domain

84..203

PF08361 MAATS-type transcriptional repressor, C-terminal region

PMID:19920124[8]

<motif_map/>

Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=envR taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

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Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type Source Notes/Reference

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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

NCBI (Protein) (EcoliWiki Page)

GI:16131152

Escherichia coli str. K-12 substr. MG1655

NCBI (Protein) (EcoliWiki Page)

GeneID:947704

Escherichia coli str. K-12 substr. MG1655

ASAP

ASAP:ABE-0010712

Escherichia coli str. K-12 substr. MG1655

UniProt (EcoliWiki Page)

UniProtKB/Swiss-Prot:P0ACT2

Escherichia coli str. K-12 substr. MG1655

EcoCyc

EcoCyc:EG11741

Escherichia coli str. K-12 substr. MG1655

EcoGene

EcoGene:EG11741

Escherichia coli str. K-12 substr. MG1655

NCBI (Gene) (EcoliWiki Page)

GeneID:947704

Escherichia coli str. K-12 substr. MG1655

RegulonDB

RegulonDB:ECK120001680

Escherichia coli str. K-12 substr. MG1655

EchoBASE

EchoBASE:EB1692

Escherichia coli str. K-12 substr. MG1655

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Notes

Links

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References

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See Help:References for how to manage references in EcoliWiki.

  1. 1.0 1.1 1.2 1.3 1.4 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. 2.0 2.1 2.2 2.3 2.4 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  5. 5.0 5.1 5.2 Hirakawa, H et al. (2008) AcrS/EnvR represses expression of the acrAB multidrug efflux genes in Escherichia coli. J. Bacteriol. 190 6276-9 PubMed
  6. 6.0 6.1 6.2 Yang, K et al. (1995) Regulation of jadomycin B production in Streptomyces venezuelae ISP5230: involvement of a repressor gene, jadR2. J. Bacteriol. 177 6111-7 PubMed
  7. Arifuzzaman, M et al. (2006) Large-scale identification of protein-protein interaction of Escherichia coli K-12. Genome Res. 16 686-91 PubMed
  8. 8.0 8.1 Finn, RD et al. (2010) The Pfam protein families database. Nucleic Acids Res. 38 D211-22 PubMed

Categories

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