PMID:18567659
| Citation |
Hirakawa, H, Takumi-Kobayashi, A, Theisen, U, Hirata, T, Nishino, K and Yamaguchi, A (2008) AcrS/EnvR represses expression of the acrAB multidrug efflux genes in Escherichia coli. J. Bacteriol. 190:6276-9 |
|---|---|
| Abstract |
The acrS regulatory gene is located upstream of the acrEF multidrug efflux system genes. However, the roles of AcrS in regulation of drug efflux pumps have not been clearly understood. Here we show that AcrS represses other multidrug efflux genes, acrAB, which encode a major efflux system in Escherichia coli. |
| Links |
PubMed PMC2546796 Online version:10.1128/JB.00190-08 |
| Keywords |
Anti-Bacterial Agents/pharmacology; Base Sequence; Binding Sites; Electrophoretic Mobility Shift Assay; Escherichia coli/drug effects; Escherichia coli/genetics; Escherichia coli/metabolism; Escherichia coli Proteins/genetics; Escherichia coli Proteins/metabolism; Gene Expression Regulation, Bacterial; Lipoproteins/genetics; Lipoproteins/metabolism; Membrane Transport Proteins/genetics; Membrane Transport Proteins/metabolism; Multidrug Resistance-Associated Proteins/genetics; Multidrug Resistance-Associated Proteins/metabolism; Repressor Proteins/genetics; Repressor Proteins/metabolism |
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