dosP:Gene Product(s)

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Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

DosP

Synonyms

cAMP phosphodiesterase, heme-regulated[1], B1489[2][1], YddU[2][1], DosP[2][1] , dos, ECK1483, JW1484, yddU, b1489

Product description

phosphodiesterase, heme-regulated[2][3];

Component of phosphodiesterase, heme-regulated[3]

c-di-GMP phosphodiesterase, heme-regulated oxygen sensor; may have weak cAMP PDE activity; tetrameric[4]

EC number (for enzymes)


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Notes

Function

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<protect> Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000155

two-component sensor activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000700

F

Seeded from EcoCyc (v14.0)

complete

GO:0000160

two-component signal transduction system (phosphorelay)

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000700

P

Seeded from EcoCyc (v14.0)

complete

GO:0000287

magnesium ion binding

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0460

F

Seeded from EcoCyc (v14.0)

complete

GO:0000287

magnesium ion binding

PMID:14551206[5]

IMP: Inferred from Mutant Phenotype

F

Seeded from EcoCyc (v14.0)

complete

GO:0004871

signal transducer activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000014

F

Seeded from EcoCyc (v14.0)

complete

GO:0006355

regulation of transcription, DNA-dependent

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001610

P

Seeded from EcoCyc (v14.0)

complete

GO:0006355

regulation of transcription, DNA-dependent

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR013767

P

Seeded from EcoCyc (v14.0)

complete

GO:0007165

signal transduction

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000014

P

Seeded from EcoCyc (v14.0)

complete

GO:0007165

signal transduction

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001610

P

Seeded from EcoCyc (v14.0)

complete

GO:0020037

heme binding

PMID:10704219[6]

IDA: Inferred from Direct Assay

F

Seeded from EcoCyc (v14.0)

complete

GO:0050896

response to stimulus

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0716

P

Seeded from EcoCyc (v14.0)

complete

GO:0071111

cyclic-guanylate-specific phosphodiesterase activity

PMID:15995192[7]

IDA: Inferred from Direct Assay

F

Seeded from EcoCyc (v14.0)

complete

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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type Partner Notes References Evidence

Protein

Subunits of phosphodiesterase, heme-regulated

could be indirect

Protein

kdsD

PMID:16606699[8]

Experiment(s):EBI-1139971

Protein

talA

PMID:16606699[8]

Experiment(s):EBI-1139971
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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment Description Evidence Reference/Source Notes
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Notes

Structure and Physical Properties

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<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence

at EcoCyc 

MRQDAEVIMK LTDADNAADG IFFPALEQNM MGAVLINEND EVMFFNPAAE KLWGYKREEV
IGNNIDMLIP RDLRPAHPEY IRHNREGGKA RVEGMSRELQ LEKKDGSKIW TRFALSKVSA
EGKVYYLALV RDASVEMAQK EQTRQLIIAV DHLDRPVIVL DPERHIVQCN RAFTEMFGYC
ISEASGMQPD TLLNIPEFPA DNRIRLQQLL WKTARDQDEF LLLTRTGEKI WIKASISPVY
DVLAHLQNLV MTFSDITEER QIRQLEGNIL AAMCSSPPFH EMGEIICRNI ESVLNESHVS
LFALRNGMPI HWASSSHGAE IQNAQSWSAT IRQRDGAPAG ILQIKTSSGA ETSAFIERVA
DISQHMAALA LEQEKSRQHI EQLIQFDPMT GLPNRNNLHN YLDDLVDKAV SPVVYLIGVD
HIQDVIDSLG YAWADQALLE VVNRFREKLK PDQYLCRIEG TQFVLVSLEN DVSNITQIAD
ELRNVVSKPI MIDDKPFPLT LSIGISYDLG KNRDYLLSTA HNAMDYIRKN GGNGWQFFSP
AMNEMVKERL VLGAALKEAI SNNQLKLVYQ PQIFAETGEL YGIEALARWH DPLHGHVPPS
RFIPLAEEIG EIENIGRWVI AEACRQLAEW RSQNIHIPAL SVNLSALHFR SNQLPNQVSD
AMHAWGIDGH QLTVEITESM MMEHDTEIFK RIQILRDMGV GLSVDDFGTG FSGLSRLVSL
PVTEIKIDKS FVDRCLTEKR ILALLEAITS IGQSLNLTVV AEGVETKEQF EMLRKIHCRV
IQGYFFSRPL PAEEIPGWMS SVLPLKI
Length

807

Mol. Wt

91.205 kDa

pI

5.3 (calculated)

Extinction coefficient

95,340 - 96,340 (calc based on 16 Y, 13 W, and 8 C residues)

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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type Residues Description Notes References

Domain

376..526

PF00990 GGDEF domain

PMID:19920124[9]

Domain

545..781

PF00563 EAL domain

PMID:19920124[9]

Domain

16..125

PF00989 PAS fold

PMID:19920124[9]

Domain

142..253

PF08448 PAS fold

PMID:19920124[9]

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Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=dos taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

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Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type Source Notes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

NCBI (Protein) (EcoliWiki Page)

GI:162135902

Escherichia coli str. K-12 substr. MG1655

NCBI (Protein) (EcoliWiki Page)

GeneID:945815

Escherichia coli str. K-12 substr. MG1655

UniProt (EcoliWiki Page)

UniProtKB/Swiss-Prot:P76129

Escherichia coli str. K-12 substr. MG1655

NCBI (Gene) (EcoliWiki Page)

GeneID:945815

Escherichia coli str. K-12 substr. MG1655

RegulonDB

RegulonDB:

Escherichia coli str. K-12 substr. MG1655

EchoBASE

EchoBASE:

Escherichia coli str. K-12 substr. MG1655

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Notes

Links

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References

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See Help:References for how to manage references in EcoliWiki.

  1. ↑ 1.0 1.1 1.2 1.3 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ 3.0 3.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  5. ↑ Yoshimura, T et al. (2003) Relationships between heme incorporation, tetramer formation, and catalysis of a heme-regulated phosphodiesterase from Escherichia coli: a study of deletion and site-directed mutants. J. Biol. Chem. 278 53105-11 PubMed
  6. ↑ Delgado-Nixon, VM et al. (2000) Dos, a heme-binding PAS protein from Escherichia coli, is a direct oxygen sensor. Biochemistry 39 2685-91 PubMed
  7. ↑ Schmidt, AJ et al. (2005) The ubiquitous protein domain EAL is a cyclic diguanylate-specific phosphodiesterase: enzymatically active and inactive EAL domains. J. Bacteriol. 187 4774-81 PubMed
  8. ↑ 8.0 8.1 Arifuzzaman, M et al. (2006) Large-scale identification of protein-protein interaction of Escherichia coli K-12. Genome Res. 16 686-91 PubMed
  9. ↑ 9.0 9.1 9.2 9.3 Finn, RD et al. (2010) The Pfam protein families database. Nucleic Acids Res. 38 D211-22 PubMed

Categories

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