dgt:Gene Product(s)

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Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

Dgt

Synonyms

deoxyguanosine triphosphate triphosphohydrolase[1], B0160[2][1], Dgt[2][1], OptA[2][1] , ECK0159, JW0156, optA, b0160

Product description

Dgt[2][3];

Component of deoxyguanosinetriphosphate triphosphohydrolase[2][3]

Deoxyguanosine 5'-triphosphate triphosphohydrolase[4]

EC number (for enzymes)
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Notes

Deoxyguanosine triphosphate triphosphohydrolase was identified by Dr. Sylvy Kornberg as an inhibitor of in vitro DNA replication in the Kornberg lab.[5]

Function

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<protect> Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000287

magnesium ion binding

GOA:hamap
GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_00030

F

Seeded from EcoCyc (v14.0)

complete

GO:0000287

magnesium ion binding

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR006261

F

Seeded from EcoCyc (v14.0)

complete

GO:0000287

magnesium ion binding

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR020779

F

Seeded from EcoCyc (v14.0)

complete

GO:0000287

magnesium ion binding

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0460

F

Seeded from EcoCyc (v14.0)

complete

GO:0008832

dGTPase activity

GOA:hamap
GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_00030

F

Seeded from EcoCyc (v14.0)

complete

GO:0008832

dGTPase activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR006261

F

Seeded from EcoCyc (v14.0)

complete

GO:0008832

dGTPase activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR020779

F

Seeded from EcoCyc (v14.0)

complete

GO:0008832

dGTPase activity

PMID:2833745[6]

IDA: Inferred from Direct Assay

F

complete

GO:0008832

dGTPase activity

GOA:spec
GO_REF:0000003

IEA: Inferred from Electronic Annotation

EC:3.1.5.1

F

Seeded from EcoCyc (v14.0)

complete

GO:0046039

GTP metabolic process

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR006261

P

Seeded from EcoCyc (v14.0)

complete

GO:0003924

GTPase activity

PMID:2826481[7]

IDA: Inferred from Direct Assay

F

complete

GO:0030145

manganese ion binding

PMID:2826481[7]

IDA: Inferred from Direct Assay

F

complete

GO:0050897

cobalt ion binding

PMID:2826481[7]

IDA: Inferred from Direct Assay

F

complete

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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type Partner Notes References Evidence

Protein

Subunits of deoxyguanosinetriphosphate triphosphohydrolase

could be indirect

Protein

yacH

PMID:16606699[8]

Experiment(s):EBI-1135747

Protein

groL

PMID:16606699[8]

Experiment(s):EBI-1135747
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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment Description Evidence Reference/Source Notes
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Notes

Structure and Physical Properties

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<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence

at EcoCyc 

MAQIDFRKKI NWHRRYRSPQ GVKTEHEILR IFESDRGRII NSPAIRRLQQ KTQVFPLERN
AAVRTRLTHS MEVQQVGRYI AKEILSRLKE LKLLEAYGLD ELTGPFESIV EMSCLMHDIG
NPPFGHFGEA AINDWFRQRL HPEDAESQPL TDDRCSVAAL RLRDGEEPLN ELRRKIRQDL
CHFEGNAQGI RLVHTLMRMN LTWAQVGGIL KYTRPAWWRG ETPETHHYLM KKPGYYLSEE
AYIARLRKEL NLALYSRFPL TWIMEAADDI SYCVADLEDA VEKRIFTVEQ LYHHLHEAWG
QHEKGSLFSL VVENAWEKSR SNSLSRSTED QFFMYLRVNT LNKLVPYAAQ RFIDNLPAIF
AGTFNHALLE DASECSDLLK LYKNVAVKHV FSHPDVERLE LQGYRVISGL LEIYRPLLSL
SLSDFTELVE KERVKRFPIE SRLFHKLSTR HRLAYVEAVS KLPSDSPEFP LWEYYYRCRL
LQDYISGMTD LYAWDEYRRL MAVEQ
Length

505

Mol. Wt

59.384 kDa

pI

7.5 (calculated)

Extinction coefficient

89,270 - 90,020 (calc based on 23 Y, 10 W, and 6 C residues)

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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type Residues Description Notes References

Initiator Methionine

1

Removed

UniProt:P15723

Domain

66..183

PF01966 HD domain

PMID:19920124[9]

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Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=dgt taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

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Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type Source Notes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

NCBI (Protein) (EcoliWiki Page)

GI:16128153

Escherichia coli str. K-12 substr. MG1655

NCBI (Protein) (EcoliWiki Page)

GeneID:947177

Escherichia coli str. K-12 substr. MG1655

ASAP

ASAP:ABE-0000548

Escherichia coli str. K-12 substr. MG1655

UniProt (EcoliWiki Page)

UniProtKB/Swiss-Prot:P15723

Escherichia coli str. K-12 substr. MG1655

EcoCyc

EcoCyc:EG10225

Escherichia coli str. K-12 substr. MG1655

EcoGene

EcoGene:EG10225

Escherichia coli str. K-12 substr. MG1655

NCBI (Gene) (EcoliWiki Page)

GeneID:947177

Escherichia coli str. K-12 substr. MG1655

RegulonDB

RegulonDB:ECK120000219

Escherichia coli str. K-12 substr. MG1655

EchoBASE

EchoBASE:EB0221

Escherichia coli str. K-12 substr. MG1655

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Notes

Links

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References

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See Help:References for how to manage references in EcoliWiki.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 2.4 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ 3.0 3.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  5. ↑ KORNBERG, SR et al. (1958) Enzymatic cleavage of deoxyguanosine triphosphate to deoxyguanosine and tripolyphosphate. J. Biol. Chem. 233 159-62 PubMed
  6. ↑ Beauchamp, BB & Richardson, CC (1988) A unique deoxyguanosine triphosphatase is responsible for the optA1 phenotype of Escherichia coli. Proc. Natl. Acad. Sci. U.S.A. 85 2563-7 PubMed
  7. ↑ 7.0 7.1 7.2 Seto, D et al. (1988) The purification and properties of deoxyguanosine triphosphate triphosphohydrolase from Escherichia coli. J. Biol. Chem. 263 1494-9 PubMed
  8. ↑ 8.0 8.1 Arifuzzaman, M et al. (2006) Large-scale identification of protein-protein interaction of Escherichia coli K-12. Genome Res. 16 686-91 PubMed
  9. ↑ Finn, RD et al. (2010) The Pfam protein families database. Nucleic Acids Res. 38 D211-22 PubMed

Categories

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