csrA:Gene Product(s)

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Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

CsrA

Synonyms

pleiotropic regulatory protein for carbon source metabolism[1], B2696[2][1], ZfiA[2][1], CsrA[2][1] , ECK2691, JW2666, zfiA, b2696

Product description

carbon storage regulator; controls glycogen synthesis, gluconeogenesis, cell size and surface properties[2][3];

Component of CsrA complex with CsrB RNA[3]

Global regulator of carbon source metabolism; CsrA exerts reciprocal effects on glycolysis versus gluconeogenesis and glycogen biosynthesis; glgC mRNA-binding activity blocks GlgC translation; csrB RNA inhibits csrA[4]

EC number (for enzymes)


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Notes

Function

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<protect> Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0003723

RNA binding

GOA:hamap
GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_00167

F

Seeded from EcoCyc (v14.0)

complete

GO:0003723

RNA binding

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR003751

F

Seeded from EcoCyc (v14.0)

complete

GO:0003723

RNA binding

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0694

F

Seeded from EcoCyc (v14.0)

complete

GO:0006109

regulation of carbohydrate metabolic process

GOA:hamap
GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_00167

P

Seeded from EcoCyc (v14.0)

complete

GO:0006109

regulation of carbohydrate metabolic process

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR003751

P

Seeded from EcoCyc (v14.0)

complete

GO:0006402

mRNA catabolic process

GOA:hamap
GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_00167

P

Seeded from EcoCyc (v14.0)

complete

GO:0006402

mRNA catabolic process

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR003751

P

Seeded from EcoCyc (v14.0)

complete

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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type Partner Notes References Evidence

Protein

Subunits of CsrA complex with CsrB RNA

could be indirect

Protein

dnaN

PMID:19402753[5]

LCMS(ID Probability):99.6 MALDI(Z-score):35.462038

Protein

rpmC

PMID:19402753[5]

LCMS(ID Probability):99.6

Protein

eno

PMID:19402753[5]

LCMS(ID Probability):99.6

Protein

rplE

PMID:19402753[5]

LCMS(ID Probability):99.6

Protein

rplR

PMID:19402753[5]

LCMS(ID Probability):99.6

Protein

rpmB

PMID:19402753[5]

LCMS(ID Probability):99.6

Protein

tig

PMID:19402753[5]

LCMS(ID Probability):99.6 MALDI(Z-score):39.245483

Protein

rpsN

PMID:19402753[5]

LCMS(ID Probability):99.6

Protein

rplT

PMID:19402753[5]

LCMS(ID Probability):99.6

Protein

rplO

PMID:19402753[5]

LCMS(ID Probability):99.6

Protein

rho

PMID:19402753[5]

LCMS(ID Probability):99.6 MALDI(Z-score):39.045828

Protein

hupA

PMID:19402753[5]

LCMS(ID Probability):99.6

Protein

hupB

PMID:19402753[5]

LCMS(ID Probability):99.6

Protein

rpsA

PMID:19402753[5]

LCMS(ID Probability):99.6 MALDI(Z-score):23.860281

Protein

rpsI

PMID:19402753[5]

LCMS(ID Probability):99.6

Protein

rplF

PMID:19402753[5]

LCMS(ID Probability):99.6 MALDI(Z-score):4.332004

Protein

rpsP

PMID:19402753[5]

LCMS(ID Probability):99.6

Protein

rplI

PMID:19402753[5]

LCMS(ID Probability):99.6

Protein

dnaJ

PMID:19402753[5]

LCMS(ID Probability):99.6

Protein

rplQ

PMID:19402753[5]

LCMS(ID Probability):99.6

Protein

rpsF

PMID:19402753[5]

LCMS(ID Probability):99.6

Protein

rpsS

PMID:19402753[5]

LCMS(ID Probability):99.6

Protein

rplS

PMID:19402753[5]

LCMS(ID Probability):99.6 MALDI(Z-score):5.648246

Protein

rplU

PMID:19402753[5]

LCMS(ID Probability):99.6

Protein

rpsM

PMID:19402753[5]

LCMS(ID Probability):99.6

Protein

rplX

PMID:19402753[5]

LCMS(ID Probability):99.6

Protein

rplM

PMID:19402753[5]

LCMS(ID Probability):99.6 MALDI(Z-score):22.179834

Protein

nagC

PMID:19402753[5]

LCMS(ID Probability):99.6 MALDI(Z-score):10.961368

Protein

rplA

PMID:19402753[5]

LCMS(ID Probability):99.6 MALDI(Z-score):18.527392

Protein

rpsC

PMID:19402753[5]

LCMS(ID Probability):99.6 MALDI(Z-score):30.548305

Protein

rpsD

PMID:19402753[5]

LCMS(ID Probability):99.6 MALDI(Z-score):31.398357

Protein

rlmL

PMID:19402753[5]

MALDI(Z-score):25.017977

Protein

skp

PMID:19402753[5]

LCMS(ID Probability):99.6

Protein

lpxD

PMID:19402753[5]

LCMS(ID Probability):99.3 MALDI(Z-score):5.587843

Protein

rpoA

PMID:19402753[5]

LCMS(ID Probability):99.6

Protein

rplD

PMID:19402753[5]

LCMS(ID Probability):99.6 MALDI(Z-score):10.391520

Protein

infC

PMID:19402753[5]

LCMS(ID Probability):99.6

Protein

rne

PMID:19402753[5]

LCMS(ID Probability):99.6

Protein

rnr

PMID:19402753[5]

LCMS(ID Probability):99.3 MALDI(Z-score):26.968435

Protein

yfiF

PMID:19402753[5]

LCMS(ID Probability):99.6

Protein

rhlB

PMID:19402753[5]

LCMS(ID Probability):99.6

Protein

deaD

PMID:19402753[5]

LCMS(ID Probability):99.6 MALDI(Z-score):28.305076

Protein

rluB

PMID:19402753[5]

MALDI(Z-score):36.330881

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Notes

CsrA-his6 binding recovers mRNA from ~700 genes. CarB and CsrC RNAs titrate out CsrA and compete with mRNA targets.

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment Description Evidence Reference/Source Notes
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Notes

Structure and Physical Properties

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<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence

at EcoCyc 

MLILTRRVGE TLMIGDEVTV TVLGVKGNQV RIGVNAPKEV SVHREEIYQR IQAEKSQQSS Y
Length

61

Mol. Wt

6.855 kDa

pI

9.6 (calculated)

Extinction coefficient

2,980 (calc based on 2 Y, 0 W, and 0 C residues)

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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type Residues Description Notes References

Domain

1..54

PF02599 Global regulator protein family

PMID:19920124[6]

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Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=csrA taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

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Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type Source Notes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

NCBI (Protein) (EcoliWiki Page)

GI:16130603

Escherichia coli str. K-12 substr. MG1655

NCBI (Protein) (EcoliWiki Page)

GeneID:947176

Escherichia coli str. K-12 substr. MG1655

ASAP

ASAP:ABE-0008866

Escherichia coli str. K-12 substr. MG1655

UniProt (EcoliWiki Page)

UniProtKB/Swiss-Prot:P69913

Escherichia coli str. K-12 substr. MG1655

EcoCyc

EcoCyc:EG11447

Escherichia coli str. K-12 substr. MG1655

EcoGene

EcoGene:EG11447

Escherichia coli str. K-12 substr. MG1655

NCBI (Gene) (EcoliWiki Page)

GeneID:947176

Escherichia coli str. K-12 substr. MG1655

RegulonDB

RegulonDB:ECK120001410

Escherichia coli str. K-12 substr. MG1655

EchoBASE

EchoBASE:EB1416

Escherichia coli str. K-12 substr. MG1655

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Notes

Links

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References

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See Help:References for how to manage references in EcoliWiki.

  1. ↑ 1.0 1.1 1.2 1.3 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ 3.0 3.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  5. ↑ 5.00 5.01 5.02 5.03 5.04 5.05 5.06 5.07 5.08 5.09 5.10 5.11 5.12 5.13 5.14 5.15 5.16 5.17 5.18 5.19 5.20 5.21 5.22 5.23 5.24 5.25 5.26 5.27 5.28 5.29 5.30 5.31 5.32 5.33 5.34 5.35 5.36 5.37 5.38 5.39 5.40 5.41 5.42 Hu, P et al. (2009) Global functional atlas of Escherichia coli encompassing previously uncharacterized proteins. PLoS Biol. 7 e96 PubMed
  6. ↑ Finn, RD et al. (2010) The Pfam protein families database. Nucleic Acids Res. 38 D211-22 PubMed

Categories

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