cirA:Gene Product(s)

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Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

CirA

Synonyms

ferric iron-catecholate outer membrane transporter[1], B2155[2][1], Cir[2][1], FeuA[2][1], CirA[2][1] , cir, ECK2148, feuA, JW2142, b2155

Product description

outer membrane receptor for iron-regulated colicin I receptor; porin; requires tonB gene[2][3]

Colicin I receptor production[4]

EC number (for enzymes)


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Notes

Function

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<protect> Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0004872

receptor activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000531

F

Seeded from EcoCyc (v14.0)

complete

GO:0004872

receptor activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR012910

F

Seeded from EcoCyc (v14.0)

complete

GO:0004872

receptor activity

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0675

F

Seeded from EcoCyc (v14.0)

complete

GO:0005215

transporter activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000531

F

Seeded from EcoCyc (v14.0)

complete

GO:0005215

transporter activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR012910

F

Seeded from EcoCyc (v14.0)

complete

GO:0005506

iron ion binding

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0408

F

Seeded from EcoCyc (v14.0)

complete

GO:0005886

plasma membrane

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-1003

C

Seeded from EcoCyc (v14.0)

complete

GO:0006810

transport

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000531

P

Seeded from EcoCyc (v14.0)

complete

GO:0006810

transport

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR012910

P

Seeded from EcoCyc (v14.0)

complete

GO:0006810

transport

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0813

P

Seeded from EcoCyc (v14.0)

complete

GO:0006811

ion transport

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0406

P

Seeded from EcoCyc (v14.0)

complete

GO:0006826

iron ion transport

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0410

P

Seeded from EcoCyc (v14.0)

complete

GO:0009279

cell outer membrane

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0998

C

Seeded from EcoCyc (v14.0)

complete

GO:0009279

cell outer membrane

GO_REF:0000023

IEA: Inferred from Electronic Annotation

SP_SL:SL-0040

C

Seeded from EcoCyc (v14.0)

complete

GO:0016020

membrane

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000531

C

Seeded from EcoCyc (v14.0)

complete

GO:0016020

membrane

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR012910

C

Seeded from EcoCyc (v14.0)

complete

GO:0016020

membrane

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0472

C

Seeded from EcoCyc (v14.0)

complete

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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type Partner Notes References Evidence

Protein

rsuA

PMID:16606699[5]

Experiment(s):EBI-1142040

Protein

tdcB

PMID:16606699[5]

Experiment(s):EBI-1142040

Protein

cho

PMID:16606699[5]

Experiment(s):EBI-1142040

Protein

sdhA

PMID:16606699[5]

Experiment(s):EBI-1142040

Protein

rpsP

PMID:19402753[6]

LCMS(ID Probability):99.5

Protein

rpsN

PMID:19402753[6]

LCMS(ID Probability):99.6

Protein

hupA

PMID:19402753[6]

LCMS(ID Probability):99.6

Protein

eno

PMID:19402753[6]

LCMS(ID Probability):99.6

Protein

rplD

PMID:19402753[6]

LCMS(ID Probability):99.6

Protein

rplJ

PMID:19402753[6]

LCMS(ID Probability):99.6

Protein

atpA

PMID:19402753[6]

MALDI(Z-score):22.019997

Protein

atpD

PMID:19402753[6]

MALDI(Z-score):27.187543

Protein

rplL

PMID:19402753[6]

LCMS(ID Probability):99.6

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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment Description Evidence Reference/Source Notes

outer membrane

From EcoCyc[3]

Outer Membrane

PMID:3316180[7], PMID:16359331[8]

EchoLocation:cirA

Outer Membrane

PMID:10430870

EchoLocation:cirA


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Notes

Structure and Physical Properties

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<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence

at EcoCyc 

MFRLNPFVRV GLCLSAISCA WPVLAVDDDG ETMVVTASSV EQNLKDAPAS ISVITQEDLQ
RKPVQNLKDV LKEVPGVQLT NEGDNRKGVS IRGLDSSYTL ILVDGKRVNS RNAVFRHNDF
DLNWIPVDSI ERIEVVRGPM SSLYGSDALG GVVNIITKKI GQKWSGTVTV DTTIQEHRDR
GDTYNGQFFT SGPLIDGVLG MKAYGSLAKR EKDDPQNSTT TDTGETPRIE GFSSRDGNVE
FAWTPNQNHD FTAGYGFDRQ DRDSDSLDKN RLERQNYSVS HNGRWDYGTS ELKYYGEKVE
NKNPGNSSPI TSESNTVDGK YTLPLTAINQ FLTVGGEWRH DKLSDAVNLT GGTSSKTSAS
QYALFVEDEW RIFEPLALTT GVRMDDHETY GEHWSPRAYL VYNATDTVTV KGGWATAFKA
PSLLQLSPDW TSNSCRGACK IVGSPDLKPE TSESWELGLY YMGEEGWLEG VESSVTVFRN
DVKDRISISR TSDVNAAPGY QNFVGFETGA NGRRIPVFSY YNVNKARIQG VETELKIPFN
DEWKLSINYT YNDGRDVSNG ENKPLSDLPF HTANGTLDWK PLALEDWSFY VSGHYTGQKR
ADSATAKTPG GYTIWNTGAA WQVTKDVKLR AGVLNLGDKD LSRDDYSYNE DGRRYFMAVD YRF
Length

663

Mol. Wt

73.896 kDa

pI

5.0 (calculated)

Extinction coefficient

135,220 - 135,720 (calc based on 28 Y, 17 W, and 4 C residues)

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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type Residues Description Notes References

motif

1-25

UniProt Manual:Signal Peptides

UniProt:P17315

Domain

395..662

PF00593 TonB dependent receptor

PMID:19920124[9]

Domain

43..152

PF07715 TonB-dependent Receptor Plug Domain

PMID:19920124[9]

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Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=cirA taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

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Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type Source Notes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

NCBI (Protein) (EcoliWiki Page)

GI:16130093

Escherichia coli str. K-12 substr. MG1655

NCBI (Protein) (EcoliWiki Page)

GeneID:949042

Escherichia coli str. K-12 substr. MG1655

ASAP

ASAP:ABE-0007126

Escherichia coli str. K-12 substr. MG1655

UniProt (EcoliWiki Page)

UniProtKB/Swiss-Prot:P17315

Escherichia coli str. K-12 substr. MG1655

EcoCyc

EcoCyc:EG10155

Escherichia coli str. K-12 substr. MG1655

EcoGene

EcoGene:EG10155

Escherichia coli str. K-12 substr. MG1655

NCBI (Gene) (EcoliWiki Page)

GeneID:949042

Escherichia coli str. K-12 substr. MG1655

RegulonDB

RegulonDB:ECK120000151

Escherichia coli str. K-12 substr. MG1655

EchoBASE

EchoBASE:EB0153

Escherichia coli str. K-12 substr. MG1655

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Notes

Links

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References

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See Help:References for how to manage references in EcoliWiki.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 2.4 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ 3.0 3.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  5. ↑ 5.0 5.1 5.2 5.3 Arifuzzaman, M et al. (2006) Large-scale identification of protein-protein interaction of Escherichia coli K-12. Genome Res. 16 686-91 PubMed
  6. ↑ 6.0 6.1 6.2 6.3 6.4 6.5 6.6 6.7 6.8 Hu, P et al. (2009) Global functional atlas of Escherichia coli encompassing previously uncharacterized proteins. PLoS Biol. 7 e96 PubMed
  7. ↑ Griggs, DW et al. (1987) Cloning and promoter identification of the iron-regulated cir gene of Escherichia coli. J. Bacteriol. 169 5343-52 PubMed
  8. ↑ Guillier, M & Gottesman, S (2006) Remodelling of the Escherichia coli outer membrane by two small regulatory RNAs. Mol. Microbiol. 59 231-47 PubMed
  9. ↑ 9.0 9.1 Finn, RD et al. (2010) The Pfam protein families database. Nucleic Acids Res. 38 D211-22 PubMed

Categories

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