argP:Gene Product(s)

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Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

ArgP

Synonyms

DNA-binding transcriptional activator, replication initiation inhibitor[1], B2916[2][1], ArgP[2][1], IciA[2][1][3] , can, canR, ECK2912, iciA, JW2883, b2916

Product description

ArgP transcriptional activator[2][4]

Arginine and lysine responsive transcriptional regulator; inhibitor of chromosome initiation; positive regulator of argK, negative autoregulator in presence of arginine; oriC iteron (13-mer) binding protein, competes with DnaA for iteron binding; activate[5]

EC number (for enzymes)


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Notes

Function

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<protect> Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0003700

transcription factor activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000847

F

Seeded from EcoCyc (v14.0)

complete

GO:0003700

transcription factor activity

PMID:10600368[3]

IDA: Inferred from Direct Assay

F

Seeded from EcoCyc (v14.0)

complete

GO:0003700

transcription factor activity

PMID:2034653[6]

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P12529
UniProtKB:P0A2Q4
UniProtKB:P10183

F

Seeded from EcoCyc (v14.0)

complete

GO:0043565

sequence-specific DNA binding

PMID:10600368[3]

IDA: Inferred from Direct Assay

F

complete

GO:0016563

transcription activator activity

PMID:10600368[3]

IDA: Inferred from Direct Assay

F

Seeded from EcoCyc (v14.0)

complete

GO:0016563

transcription activator activity

PMID:2034653[6]

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P12529
UniProtKB:P0A2Q4
UniProtKB:P10183

F

Seeded from EcoCyc (v14.0)

complete

GO:0016566

specific transcriptional repressor activity

PMID:10600368[3]

IDA: Inferred from Direct Assay

F

Seeded from EcoCyc (v14.0)

complete

GO:0016566

specific transcriptional repressor activity

PMID:2034653[6]

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P12529
UniProtKB:P0A2Q4
UniProtKB:P10183

F

Seeded from EcoCyc (v14.0)

complete

GO:0032297

negative regulation of DNA-dependent DNA replication initiation

PMID:1429656[7]

IDA: Inferred from Direct Assay

P

Seeded from EcoCyc (v14.0)

complete

GO:0032582

negative regulation of gene-specific transcription

PMID:10600368[3]

IDA: Inferred from Direct Assay

P

Seeded from EcoCyc (v14.0)

complete

GO:0032582

negative regulation of gene-specific transcription

PMID:2034653[6]

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P12529
UniProtKB:P0A2Q4
UniProtKB:P10183

P

Seeded from EcoCyc (v14.0)

complete

GO:0043193

positive regulation of gene-specific transcription

PMID:10600368[3]

IDA: Inferred from Direct Assay

P

Seeded from EcoCyc (v14.0)

complete

GO:0043193

positive regulation of gene-specific transcription

PMID:2034653[6]

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P12529
UniProtKB:P0A2Q4
UniProtKB:P10183

P

Seeded from EcoCyc (v14.0)

complete

GO:0003681

bent DNA binding

PMID:10551881[8]

IDA: Inferred from Direct Assay

F

complete

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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type Partner Notes References Evidence

Protein

nanR

PMID:16606699[9]

Experiment(s):EBI-1144289

Protein

glgB

PMID:16606699[9]

Experiment(s):EBI-1144289

Protein

rpsI

PMID:16606699[9]

Experiment(s):EBI-1144289

Protein

groL

PMID:15690043[10]

Experiment(s):EBI-888615

Protein

tufA

PMID:15690043[10]

Experiment(s):EBI-888615

Protein

groL

PMID:19402753[11]

MALDI(Z-score):17.053160

Protein

groS

PMID:19402753[11]

MALDI(Z-score):23.054402

Protein

tufB

PMID:19402753[11]

MALDI(Z-score):25.460787

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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment Description Evidence Reference/Source Notes
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Notes

Structure and Physical Properties

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<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence

at EcoCyc 

MKRPDYRTLQ ALDAVIRERG FERAAQKLCI TQSAVSQRIK QLENMFGQPL LVRTVPPRPT
EQGQKLLALL RQVELLEEEW LGDEQTGSTP LLLSLAVNAD SLATWLLPAL APVLADSPIR
LNLQVEDETR TQERLRRGEV VGAVSIQHQA LPSCLVDKLG ALDYLFVSSK PFAEKYFPNG
VTRSALLKAP VVAFDHLDDM HQAFLQQNFD LPPGSVPCHI VNSSEAFVQL ARQGTTCCMI
PHLQIEKELA SGELIDLTPG LFQRRMLYWH RFAPESRMMR KVTDALLDYG HKVLRQD
Length

297

Mol. Wt

33.471 kDa

pI

6.9 (calculated)

Extinction coefficient

23,950 - 24,575 (calc based on 5 Y, 3 W, and 5 C residues)

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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type Residues Description Notes References

Domain

88..290

PF03466 LysR substrate binding domain

PMID:19920124[12]

Domain

6..64

PF00126 Bacterial regulatory helix-turn-helix protein, lysR family

PMID:19920124[12]

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Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=argP taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

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Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type Source Notes/Reference

Purification protocol

PMID:10600368[3]

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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

NCBI (Protein) (EcoliWiki Page)

GI:16130817

Escherichia coli str. K-12 substr. MG1655

NCBI (Protein) (EcoliWiki Page)

GeneID:944867

Escherichia coli str. K-12 substr. MG1655

ASAP

ASAP:ABE-0009574

Escherichia coli str. K-12 substr. MG1655

UniProt (EcoliWiki Page)

UniProtKB/Swiss-Prot:P0A8S1

Escherichia coli str. K-12 substr. MG1655

EcoCyc

EcoCyc:EG10490

Escherichia coli str. K-12 substr. MG1655

EcoGene

EcoGene:EG10490

Escherichia coli str. K-12 substr. MG1655

NCBI (Gene) (EcoliWiki Page)

GeneID:944867

Escherichia coli str. K-12 substr. MG1655

RegulonDB

RegulonDB:ECK120000483

Escherichia coli str. K-12 substr. MG1655

EchoBASE

EchoBASE:EB0485

Escherichia coli str. K-12 substr. MG1655

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Notes

Links

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References

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See Help:References for how to manage references in EcoliWiki.

  1. ↑ 1.0 1.1 1.2 1.3 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ 3.0 3.1 3.2 3.3 3.4 3.5 3.6 3.7 Celis, RT (1999) Repression and activation of arginine transport genes in Escherichia coli K 12 by the ArgP protein. J. Mol. Biol. 294 1087-95 PubMed
  4. ↑ EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  5. ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  6. ↑ 6.0 6.1 6.2 6.3 6.4 Thöny, B et al. (1991) iciA, an Escherichia coli gene encoding a specific inhibitor of chromosomal initiation of replication in vitro. Proc. Natl. Acad. Sci. U.S.A. 88 4066-70 PubMed
  7. ↑ Hwang, DS & Kornberg, A (1992) Opposed actions of regulatory proteins, DnaA and IciA, in opening the replication origin of Escherichia coli. J. Biol. Chem. 267 23087-91 PubMed
  8. ↑ Azam, TA & Ishihama, A (1999) Twelve species of the nucleoid-associated protein from Escherichia coli. Sequence recognition specificity and DNA binding affinity. J. Biol. Chem. 274 33105-13 PubMed
  9. ↑ 9.0 9.1 9.2 Arifuzzaman, M et al. (2006) Large-scale identification of protein-protein interaction of Escherichia coli K-12. Genome Res. 16 686-91 PubMed
  10. ↑ 10.0 10.1 Butland, G et al. (2005) Interaction network containing conserved and essential protein complexes in Escherichia coli. Nature 433 531-7 PubMed
  11. ↑ 11.0 11.1 11.2 Hu, P et al. (2009) Global functional atlas of Escherichia coli encompassing previously uncharacterized proteins. PLoS Biol. 7 e96 PubMed
  12. ↑ 12.0 12.1 Finn, RD et al. (2010) The Pfam protein families database. Nucleic Acids Res. 38 D211-22 PubMed

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