aldB:Gene Product(s)

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Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

AldB

Synonyms

aldehyde dehydrogenase B[1], B3588[2][1], YiaX[2][1], AldB[2][1] , ECK3577, JW3561, yiaX, b3588

Product description

ALDDEHYDROGB[2][3];

Component of acetaldehyde dehydrogenase[3]

Aldehyde dehydrogenase, NADP-dependent; tetrameric[4]

EC number (for enzymes)
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Notes

Function

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<protect> Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0005737

cytoplasm

C

Seeded from Riley et al 2006 [1].

Missing: evidence, reference

GO:0009438

methylglyoxal metabolic process

P

Seeded from Riley et al 2006 [1].

Missing: evidence, reference

GO:0000287

magnesium ion binding

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0460

F

Seeded from EcoCyc (v14.0)

complete

GO:0016491

oxidoreductase activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR015590

F

Seeded from EcoCyc (v14.0)

complete

GO:0016491

oxidoreductase activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR016160

F

Seeded from EcoCyc (v14.0)

complete

GO:0016491

oxidoreductase activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR016161

F

Seeded from EcoCyc (v14.0)

complete

GO:0016491

oxidoreductase activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR016162

F

Seeded from EcoCyc (v14.0)

complete

GO:0045471

response to ethanol

PMID:15659684[5]

IDA: Inferred from Direct Assay

P

complete

GO:0016491

oxidoreductase activity

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0560

F

Seeded from EcoCyc (v14.0)

complete

GO:0004029

aldehyde dehydrogenase (NAD) activity

PMID:15659684[5]

IDA: Inferred from Direct Assay

F

complete

GO:0055114

oxidation reduction

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR015590

P

Seeded from EcoCyc (v14.0)

complete

GO:0016491

oxidoreductase activity

PMID:15659684[5]

IDA: Inferred from Direct Assay

F

complete

GO:0055114

oxidation reduction

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR016160

P

Seeded from EcoCyc (v14.0)

complete

GO:0055114

oxidation reduction

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR016161

P

Seeded from EcoCyc (v14.0)

complete

GO:0055114

oxidation reduction

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR016162

P

Seeded from EcoCyc (v14.0)

complete

GO:0055114

oxidation reduction

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0560

P

Seeded from EcoCyc (v14.0)

complete

GO:0006974

response to DNA damage stimulus

PMID:11967071[6]

IEP: Inferred from Expression Pattern

P

complete

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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type Partner Notes References Evidence

Protein

Subunits of acetaldehyde dehydrogenase

could be indirect

Protein

dnaK

PMID:16606699[7]

Experiment(s):EBI-1146177

Protein

ycfD

PMID:19402753[8]

LCMS(ID Probability):99.6

Protein

glcB

PMID:19402753[8]

LCMS(ID Probability):99.6

Protein

aspC

PMID:19402753[8]

LCMS(ID Probability):99.3

Protein

gatA

PMID:19402753[8]

LCMS(ID Probability):99.6

Protein

fur

PMID:19402753[8]

LCMS(ID Probability):99.6

Protein

acnB

PMID:19402753[8]

LCMS(ID Probability):99.6

Protein

gabD

PMID:19402753[8]

LCMS(ID Probability):99.6

Protein

gcvP

PMID:19402753[8]

LCMS(ID Probability):99.6

Protein

deoA

PMID:19402753[8]

LCMS(ID Probability):99.6

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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment Description Evidence Reference/Source Notes
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Notes

Structure and Physical Properties

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<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence

at EcoCyc 

MIAVVKLLPT GEDFASHVYP CYTSHRKETI MTNNPPSAQI KPGEYGFPLK LKARYDNFIG
GEWVAPADGE YYQNLTPVTG QLLCEVASSG KRDIDLALDA AHKVKDKWAH TSVQDRAAIL
FKIADRMEQN LELLATAETW DNGKPIRETS AADVPLAIDH FRYFASCIRA QEGGISEVDS
ETVAYHFHEP LGVVGQIIPW NFPLLMASWK MAPALAAGNC VVLKPARLTP LSVLLLMEIV
GDLLPPGVVN VVNGAGGVIG EYLATSKRIA KVAFTGSTEV GQQIMQYATQ NIIPVTLELG
GKSPNIFFAD VMDEEDAFFD KALEGFALFA FNQGEVCTCP SRALVQESIY ERFMERAIRR
VESIRSGNPL DSVTQMGAQV SHGQLETILN YIDIGKKEGA DVLTGGRRKL LEGELKDGYY
LEPTILFGQN NMRVFQEEIF GPVLAVTTFK TMEEALELAN DTQYGLGAGV WSRNGNLAYK
MGRGIQAGRV WTNCYHAYPA HAAFGGYKQS GIGRETHKMM LEHYQQTKCL LVSYSDKPLG LF
Length

542

Mol. Wt

59.695 kDa

pI

5.7 (calculated)

Extinction coefficient

69,790 - 70,790 (calc based on 21 Y, 7 W, and 8 C residues)

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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type Residues Description Notes References

Domain

33..500

PF00171 Aldehyde dehydrogenase family

PMID:19920124[9]

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Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=aldB taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

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Notes

Purification and kinetic properties of AldB described in [5]

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type Source Notes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

NCBI (Protein) (EcoliWiki Page)

GI:90111619

Escherichia coli str. K-12 substr. MG1655

NCBI (Protein) (EcoliWiki Page)

GeneID:948104

Escherichia coli str. K-12 substr. MG1655

ASAP

ASAP:ABE-0011718

Escherichia coli str. K-12 substr. MG1655

UniProt (EcoliWiki Page)

UniProtKB/Swiss-Prot:P37685

Escherichia coli str. K-12 substr. MG1655

EcoCyc

EcoCyc:EG12292

Escherichia coli str. K-12 substr. MG1655

EcoGene

EcoGene:EG12292

Escherichia coli str. K-12 substr. MG1655

NCBI (Gene) (EcoliWiki Page)

GeneID:948104

Escherichia coli str. K-12 substr. MG1655

RegulonDB

RegulonDB:ECK120002173

Escherichia coli str. K-12 substr. MG1655

EchoBASE

EchoBASE:EB2200

Escherichia coli str. K-12 substr. MG1655

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Notes

Links

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References

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See Help:References for how to manage references in EcoliWiki.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ 3.0 3.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  5. ↑ 5.0 5.1 5.2 5.3 Ho, KK & Weiner, H (2005) Isolation and characterization of an aldehyde dehydrogenase encoded by the aldB gene of Escherichia coli. J. Bacteriol. 187 1067-73 PubMed
  6. ↑ Khil, PP & Camerini-Otero, RD (2002) Over 1000 genes are involved in the DNA damage response of Escherichia coli. Mol. Microbiol. 44 89-105 PubMed
  7. ↑ Arifuzzaman, M et al. (2006) Large-scale identification of protein-protein interaction of Escherichia coli K-12. Genome Res. 16 686-91 PubMed
  8. ↑ 8.0 8.1 8.2 8.3 8.4 8.5 8.6 8.7 8.8 Hu, P et al. (2009) Global functional atlas of Escherichia coli encompassing previously uncharacterized proteins. PLoS Biol. 7 e96 PubMed
  9. ↑ Finn, RD et al. (2010) The Pfam protein families database. Nucleic Acids Res. 38 D211-22 PubMed

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