aldA:Gene Product(s)

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Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

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Standard name

AldA

Synonyms

aldehyde dehydrogenase A, NAD-linked[1], B1415[2][1], Ald[2][1], AldA[2][1] , ald, ECK1408, JW1412, b1415

Product description

AldA[2][3];

Component of aldehyde dehydrogenase A, NAD-linked[2][3]

Aldehyde dehydrogenase, NAD-dependent; active on lactaldehyde, glycolaldehyde, and other aldehydes[4]

EC number (for enzymes)

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Notes

Function

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<protect> Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0005737

cytoplasm

C

Seeded from Riley et al 2006 [1].

Missing: evidence, reference

GO:0008911

lactaldehyde dehydrogenase activity

PMID:4310089[5]

IDA: Inferred from Direct Assay

F

complete

Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type Partner Notes References Evidence

Protein

Subunits of aldehyde dehydrogenase A, NAD-linked

could be indirect

Protein

rhsA

PMID:16606699[6]

Experiment(s):EBI-1139800

Protein

rhsC

PMID:16606699[6]

Experiment(s):EBI-1139800

Protein

glcB

PMID:19402753[7]

LCMS(ID Probability):99.6

Protein

edd

PMID:19402753[7]

LCMS(ID Probability):99.6

Protein

fur

PMID:19402753[7]

LCMS(ID Probability):99.6

Protein

acnB

PMID:19402753[7]

LCMS(ID Probability):99.6 MALDI(Z-score):5.410000

Protein

gcvP

PMID:19402753[7]

LCMS(ID Probability):99.6

Protein

gabD

PMID:19402753[7]

LCMS(ID Probability):99.6

Protein

folD

PMID:19402753[7]

LCMS(ID Probability):99.6

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Notes

Localization

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Compartment Description Evidence Reference/Source Notes

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Notes

Structure and Physical Properties

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<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence

at EcoCyc

MSVPVQHPMY IDGQFVTWRG DAWIDVVNPA TEAVISRIPD GQAEDARKAI DAAERAQPEW
EALPAIERAS WLRKISAGIR ERASEISALI VEEGGKIQQL AEVEVAFTAD YIDYMAEWAR
RYEGEIIQSD RPGENILLFK RALGVTTGIL PWNFPFFLIA RKMAPALLTG NTIVIKPSEF
TPNNAIAFAK IVDEIGLPRG VFNLVLGRGE TVGQELAGNP KVAMVSMTGS VSAGEKIMAT
AAKNITKVCL ELGGKAPAIV MDDADLELAV KAIVDSRVIN SGQVCNCAER VYVQKGIYDQ
FVNRLGEAMQ AVQFGNPAER NDIAMGPLIN AAALERVEQK VARAVEEGAR VAFGGKAVEG
KGYYYPPTLL LDVRQEMSIM HEETFGPVLP VVAFDTLEDA ISMANDSDYG LTSSIYTQNL
NVAMKAIKGL KFGETYINRE NFEAMQGFHA GWRKSGIGGA DGKHGLHEYL QTQVVYLQS
Length

479

Mol. Wt

52.272 kDa

pI

4.9 (calculated)

Extinction coefficient

59,360 - 59,735 (calc based on 14 Y, 7 W, and 3 C residues)


Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type Residues Description Notes References

Initiator Methionine

1

Removed

UniProt:P25553

Domain

15..475

PF00171 Aldehyde dehydrogenase family

PMID:19920124[8]

<motif_map/>

Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=aldA taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

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Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type Source Notes/Reference

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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

NCBI (Protein) (EcoliWiki Page)

GI:16129376

Escherichia coli str. K-12 substr. MG1655

NCBI (Protein) (EcoliWiki Page)

GeneID:945672

Escherichia coli str. K-12 substr. MG1655

ASAP

ASAP:ABE-0004725

Escherichia coli str. K-12 substr. MG1655

UniProt (EcoliWiki Page)

UniProtKB/Swiss-Prot:P25553

Escherichia coli str. K-12 substr. MG1655

EcoCyc

EcoCyc:EG10035

Escherichia coli str. K-12 substr. MG1655

EcoGene

EcoGene:EG10035

Escherichia coli str. K-12 substr. MG1655

NCBI (Gene) (EcoliWiki Page)

GeneID:945672

Escherichia coli str. K-12 substr. MG1655

RegulonDB

RegulonDB:ECK120000032

Escherichia coli str. K-12 substr. MG1655

EchoBASE

EchoBASE:EB0034

Escherichia coli str. K-12 substr. MG1655

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Notes

Links

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References

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See Help:References for how to manage references in EcoliWiki.

  1. 1.0 1.1 1.2 1.3 1.4 1.5 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. 2.0 2.1 2.2 2.3 2.4 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. 3.0 3.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  5. Sridhara, S & Wu, TT (1969) Purification and properties of lactaldehyde dehydrogenase from Escherichia coli. J. Biol. Chem. 244 5233-8 PubMed
  6. 6.0 6.1 Arifuzzaman, M et al. (2006) Large-scale identification of protein-protein interaction of Escherichia coli K-12. Genome Res. 16 686-91 PubMed
  7. 7.0 7.1 7.2 7.3 7.4 7.5 7.6 Hu, P et al. (2009) Global functional atlas of Escherichia coli encompassing previously uncharacterized proteins. PLoS Biol. 7 e96 PubMed
  8. Finn, RD et al. (2010) The Pfam protein families database. Nucleic Acids Res. 38 D211-22 PubMed

Categories

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