acpS:Gene Product(s)

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Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

AcpS

Synonyms

holo-[acyl-carrier-protein] synthase 1[1], B2563[2][1], Dpj[2][1], AcpS[2][1] , dpj, ECK2561, JW2547, b2563

Product description

AcpS[2][3];

Component of [[:Category:Complex:holo-[acyl-carrier-protein] synthase|holo-[acyl-carrier-protein] synthase]][2][3]

ACP-CoA phosphopantetheinyltransferase; Holo-ACP synthase[4]

EC number (for enzymes)
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Notes

Function

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<protect> Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000287

magnesium ion binding

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR002582

F

Seeded from EcoCyc (v14.0)

complete

GO:0000287

magnesium ion binding

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR004568

F

Seeded from EcoCyc (v14.0)

complete

GO:0000287

magnesium ion binding

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR008278

F

Seeded from EcoCyc (v14.0)

complete

GO:0000287

magnesium ion binding

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0460

F

Seeded from EcoCyc (v14.0)

complete

GO:0005737

cytoplasm

GOA:hamap
GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_00101

C

Seeded from EcoCyc (v14.0)

complete

GO:0005737

cytoplasm

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0963

C

Seeded from EcoCyc (v14.0)

complete

GO:0005737

cytoplasm

GO_REF:0000023

IEA: Inferred from Electronic Annotation

SP_SL:SL-0086

C

Seeded from EcoCyc (v14.0)

complete

GO:0006633

fatty acid biosynthetic process

GOA:hamap
GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_00101

P

Seeded from EcoCyc (v14.0)

complete

GO:0006633

fatty acid biosynthetic process

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR002582

P

Seeded from EcoCyc (v14.0)

complete

GO:0006633

fatty acid biosynthetic process

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR004568

P

Seeded from EcoCyc (v14.0)

complete

GO:0006633

fatty acid biosynthetic process

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0275

P

Seeded from EcoCyc (v14.0)

complete

GO:0008610

lipid biosynthetic process

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0444

P

Seeded from EcoCyc (v14.0)

complete

GO:0008897

holo-(acyl-carrier-protein) synthase activity

GOA:hamap
GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_00101

F

Seeded from EcoCyc (v14.0)

complete

GO:0008897

holo-(acyl-carrier-protein) synthase activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR002582

F

Seeded from EcoCyc (v14.0)

complete

GO:0008897

holo-(acyl-carrier-protein) synthase activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR004568

F

Seeded from EcoCyc (v14.0)

complete

GO:0008897

holo-(acyl-carrier-protein) synthase activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR008278

F

Seeded from EcoCyc (v14.0)

complete

GO:0008897

holo-(acyl-carrier-protein) synthase activity

GOA:spec
GO_REF:0000003

IEA: Inferred from Electronic Annotation

EC:2.7.8.7

F

Seeded from EcoCyc (v14.0)

complete

GO:0009059

macromolecule biosynthetic process

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR008278

P

Seeded from EcoCyc (v14.0)

complete

GO:0046872

metal ion binding

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0479

F

Seeded from EcoCyc (v14.0)

complete

GO:0016740

transferase activity

PMID:7559576[5]

TAS: Traceable Author Statement

F

complete

GO:0006633

fatty acid biosynthetic process

PMID:7559576[5]

NAS: Non-traceable Author Statement

P

complete

GO:0008897

holo-(acyl-carrier-protein) synthase activity

PMID:7559576[5]

IDA: Inferred from Direct Assay

F

complete

GO:0005625

soluble fraction

PMID:7559576[5]

IDA: Inferred from Direct Assay

C

complete

GO:0042803

protein homodimerization activity

PMID:7559576[5]

IDA: Inferred from Direct Assay

F

complete

GO:0018070

peptidyl-serine phosphopantetheinylation

PMID:14294075[6]

IDA: Inferred from Direct Assay

P

complete

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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type Partner Notes References Evidence

Protein

Subunits of [[:Category:Complex:holo-[acyl-carrier-protein] synthase|holo-[acyl-carrier-protein] synthase]]

could be indirect

Protein

ybiB

PMID:16606699[7]

Experiment(s):EBI-1143271

Protein

rplD

PMID:16606699[7]

Experiment(s):EBI-1143271

Protein

groL

PMID:16606699[7]

Experiment(s):EBI-1143271

Protein

rplF

PMID:16606699[7]

Experiment(s):EBI-1143271

Protein

rplB

PMID:16606699[7]

Experiment(s):EBI-1143271

Protein

oxyR

PMID:16606699[7]

Experiment(s):EBI-1143271

Protein

rpsG

PMID:16606699[7]

Experiment(s):EBI-1143271

Protein

yfeK

PMID:16606699[7]

Experiment(s):EBI-1143271

Protein

yphE

PMID:16606699[7]

Experiment(s):EBI-1143271

Protein

rpsC

PMID:16606699[7]

Experiment(s):EBI-1143271

Protein

tufB

PMID:19402753[8]

MALDI(Z-score):18.215873

Protein

murC

PMID:19402753[8]

MALDI(Z-score):24.922879

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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment Description Evidence Reference/Source Notes
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Notes

Structure and Physical Properties

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<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence

at EcoCyc 

MAILGLGTDI VEIARIEAVI ARSGDRLARR VLSDNEWAIW KTHHQPVRFL AKRFAVKEAA
AKAFGTGIRN GLAFNQFEVF NDELGKPRLR LWGEALKLAE KLGVANMHVT LADERHYACA
TVIIES
Length

126

Mol. Wt

14.052 kDa

pI

9.6 (calculated)

Extinction coefficient

17,990 - 18,115 (calc based on 1 Y, 3 W, and 1 C residues)

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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type Residues Description Notes References

Initiator Methionine

1

Removed

UniProt:P24224

Domain

6..73

PF01648 4'-phosphopantetheinyl transferase superfamily

PMID:19920124[9]

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<motif_map/>

Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=acpS taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

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Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type Source Notes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

NCBI (Protein) (EcoliWiki Page)

GI:16130488

Escherichia coli str. K-12 substr. MG1655

NCBI (Protein) (EcoliWiki Page)

GeneID:947037

Escherichia coli str. K-12 substr. MG1655

ASAP

ASAP:ABE-0008433

Escherichia coli str. K-12 substr. MG1655

UniProt (EcoliWiki Page)

UniProtKB/Swiss-Prot:P24224

Escherichia coli str. K-12 substr. MG1655

EcoCyc

EcoCyc:EG10247

Escherichia coli str. K-12 substr. MG1655

EcoGene

EcoGene:EG10247

Escherichia coli str. K-12 substr. MG1655

NCBI (Gene) (EcoliWiki Page)

GeneID:947037

Escherichia coli str. K-12 substr. MG1655

RegulonDB

RegulonDB:ECK120000241

Escherichia coli str. K-12 substr. MG1655

EchoBASE

EchoBASE:EB0243

Escherichia coli str. K-12 substr. MG1655

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Notes

Links

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References

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See Help:References for how to manage references in EcoliWiki.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 2.4 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ 3.0 3.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  5. ↑ 5.0 5.1 5.2 5.3 5.4 Lambalot, RH & Walsh, CT (1995) Cloning, overproduction, and characterization of the Escherichia coli holo-acyl carrier protein synthase. J. Biol. Chem. 270 24658-61 PubMed
  6. ↑ MAJERUS, PW et al. (1965) ACYL CARRIER PROTEIN. IV. THE IDENTIFICATION OF 4'-PHOSPHOPANTETHEINE AS THE PROSTHETIC GROUP OF THE ACYL CARRIER PROTEIN. Proc. Natl. Acad. Sci. U.S.A. 53 410-7 PubMed
  7. ↑ 7.0 7.1 7.2 7.3 7.4 7.5 7.6 7.7 7.8 7.9 Arifuzzaman, M et al. (2006) Large-scale identification of protein-protein interaction of Escherichia coli K-12. Genome Res. 16 686-91 PubMed
  8. ↑ 8.0 8.1 Hu, P et al. (2009) Global functional atlas of Escherichia coli encompassing previously uncharacterized proteins. PLoS Biol. 7 e96 PubMed
  9. ↑ Finn, RD et al. (2010) The Pfam protein families database. Nucleic Acids Res. 38 D211-22 PubMed

Categories

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