acpP:Gene Product(s)

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Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

AcpP

Synonyms

acyl carrier protein (ACP)[1], B1094[2][1] , ECK1080, JW1080, b1094

Product description

lipoyl-ACP[2][3]

EC number (for enzymes)


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Notes

Function

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<protect> Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000036

acyl carrier activity

PMID:15459190[4]

IDA: Inferred from Direct Assay

F

complete

GO:0006633

fatty acid biosynthetic process

PMID:16352845[5]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0008610

lipid biosynthetic process

PMID:16352845[5]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0031177

phosphopantetheine binding

PMID:16352845[5]

IMP: Inferred from Mutant Phenotype

F

complete

GO:0005737

cytoplasm

PMID:15459190[4]

IDA: Inferred from Direct Assay

C

complete

GO:0042493

response to drug

PMID:15459190[4]

IMP: Inferred from Mutant Phenotype

P

Seeded from EcoCyc (v14.0)

complete

GO:0042493

response to drug

PMID:15459190[4]

IMP: Inferred from Mutant Phenotype

P

N-pentylpantothenamide and N-heptylpantothenamide

complete

GO:0000035

acyl binding

PMID:15459190[4]

IDA: Inferred from Direct Assay

F

complete

GO:0009245

lipid A biosynthetic process

PMID:16352845[5]

IMP: Inferred from Mutant Phenotype

P

complete

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Interactions

See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type Partner Notes References Evidence

Protein

mukB

PMID:15690043[6]

Experiment(s):EBI-878935, EBI-894594

Protein

plsB

PMID:15690043[6]

Experiment(s):EBI-878935

Protein

ribF

PMID:15690043[6]

Experiment(s):EBI-878935

Protein

rpsG

PMID:15690043[6]

Experiment(s):EBI-878935, EBI-882138

Protein

secA

PMID:15690043[6]

Experiment(s):EBI-878935

Protein

spoT

PMID:15690043[6]

Experiment(s):EBI-878935, EBI-886668

Protein

ybgC

PMID:15690043[6]

Experiment(s):EBI-878935, EBI-882138

Protein

ybgJ

PMID:15690043[6]

Experiment(s):EBI-878935

Protein

yiiD

PMID:15690043[6]

Experiment(s):EBI-878935, EBI-882138, EBI-887888

Protein

aas

PMID:15690043[6]

Experiment(s):EBI-878935

Protein

aceE

PMID:15690043[6]

Experiment(s):EBI-878935

Protein

aceF

PMID:15690043[6]

Experiment(s):EBI-878935

Protein

acpS

PMID:15690043[6]

Experiment(s):EBI-878935, EBI-882138

Protein

aidB

PMID:15690043[6]

Experiment(s):EBI-878935, EBI-882138

Protein

yccX

PMID:15690043[6]

Experiment(s):EBI-878935

Protein

insO2

PMID:15690043[6]

Experiment(s):EBI-878935

Protein

fabB

PMID:15690043[6]

Experiment(s):EBI-878935

Protein

fabF

PMID:15690043[6]

Experiment(s):EBI-878935, EBI-882138, EBI-893240

Protein

fabG

PMID:15690043[6]

Experiment(s):EBI-878935, EBI-882138

Protein

fabH

PMID:15690043[6]

Experiment(s):EBI-878935

Protein

fabZ

PMID:15690043[6]

Experiment(s):EBI-878935

Protein

glmU

PMID:15690043[6]

Experiment(s):EBI-878935, EBI-882138

Protein

lpdA

PMID:15690043[6]

Experiment(s):EBI-878935, EBI-882138

Protein

lpxD

PMID:15690043[6]

Experiment(s):EBI-878935, EBI-882138

Protein

malT

PMID:15690043[6]

Experiment(s):EBI-878935

Protein

accA

PMID:15690043[6]

Experiment(s):EBI-882138

Protein

hupB

PMID:15690043[6]

Experiment(s):EBI-882138

Protein

rplO

PMID:15690043[6]

Experiment(s):EBI-882138

Protein

rplV

PMID:15690043[6]

Experiment(s):EBI-882138

Protein

rpmB

PMID:15690043[6]

Experiment(s):EBI-882138

Protein

rpsF

PMID:15690043[6]

Experiment(s):EBI-882138

Protein

rpsH

PMID:15690043[6]

Experiment(s):EBI-882138

Protein

rpsM

PMID:15690043[6]

Experiment(s):EBI-882138

Protein

yhbY

PMID:15690043[6]

Experiment(s):EBI-882138

Protein

rpsM

PMID:19402753[7]

LCMS(ID Probability):99.6

Protein

accA

PMID:19402753[7]

LCMS(ID Probability):99.6

Protein

hupB

PMID:19402753[7]

LCMS(ID Probability):99.6

Protein

rpsF

PMID:19402753[7]

LCMS(ID Probability):99.6

Protein

yhbY

PMID:19402753[7]

LCMS(ID Probability):99.6

Protein

lpxD

PMID:19402753[7]

LCMS(ID Probability):99.6 MALDI(Z-score):37.890659

Protein

rplO

PMID:19402753[7]

LCMS(ID Probability):99.6

Protein

rpsH

PMID:19402753[7]

LCMS(ID Probability):99.6

Protein

plsB

PMID:19402753[7]

MALDI(Z-score):28.115910

Protein

aidB

PMID:19402753[7]

LCMS(ID Probability):99.6 MALDI(Z-score):28.483346

Protein

yiiD

PMID:19402753[7]

LCMS(ID Probability):99.6 MALDI(Z-score):39.085879

Protein

ybgC

PMID:19402753[7]

LCMS(ID Probability):99.6 MALDI(Z-score):25.238576

Protein

fabB

PMID:19402753[7]

MALDI(Z-score):47.576368

Protein

fabF

PMID:19402753[7]

LCMS(ID Probability):99.6 MALDI(Z-score):38.711597

Protein

fabG

PMID:19402753[7]

LCMS(ID Probability):99.6 MALDI(Z-score):17.053160

Protein

ribF

PMID:19402753[7]

MALDI(Z-score):36.845456

Protein

acpS

PMID:19402753[7]

LCMS(ID Probability):99.6 MALDI(Z-score):21.026827

Protein

aas

PMID:19402753[7]

MALDI(Z-score):28.197629

Protein

glmU

PMID:19402753[7]

LCMS(ID Probability):99.6 MALDI(Z-score):39.768280

Protein

rplL

PMID:19402753[7]

LCMS(ID Probability):99.6

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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment Description Evidence Reference/Source Notes
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Notes

Structure and Physical Properties

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<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence

at EcoCyc 

MSTIEERVKK IIGEQLGVKQ EEVTNNASFV EDLGADSLDT VELVMALEEE FDTEIPDEEA
EKITTVQAAI DYINGHQA
Length

78

Mol. Wt

8.638 kDa

pI

3.8 (calculated)

Extinction coefficient

1,490 (calc based on 1 Y, 0 W, and 0 C residues)

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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type Residues Description Notes References

Initiator Methionine

1

Removed

UniProt:P0A6A8

Domain

6..73

PF00550 Phosphopantetheine attachment site

PMID:19920124[8]

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Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=acpP taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

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Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type Source Notes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

NCBI (Protein) (EcoliWiki Page)

GI:16129057

Escherichia coli str. K-12 substr. MG1655

NCBI (Protein) (EcoliWiki Page)

GeneID:944805

Escherichia coli str. K-12 substr. MG1655

ASAP

ASAP:ABE-0003703

Escherichia coli str. K-12 substr. MG1655

UniProt (EcoliWiki Page)

UniProtKB/Swiss-Prot:P0A6A8

Escherichia coli str. K-12 substr. MG1655

EcoCyc

EcoCyc:EG50003

Escherichia coli str. K-12 substr. MG1655

EcoGene

EcoGene:EG50003

Escherichia coli str. K-12 substr. MG1655

NCBI (Gene) (EcoliWiki Page)

GeneID:944805

Escherichia coli str. K-12 substr. MG1655

RegulonDB

RegulonDB:ECK120002562

Escherichia coli str. K-12 substr. MG1655

EchoBASE

EchoBASE:EB4297

Escherichia coli str. K-12 substr. MG1655

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Notes

Links

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References

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See Help:References for how to manage references in EcoliWiki.

  1. ↑ 1.0 1.1 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ 4.0 4.1 4.2 4.3 4.4 Zhang, YM et al. (2004) Acyl carrier protein is a cellular target for the antibacterial action of the pantothenamide class of pantothenate antimetabolites. J. Biol. Chem. 279 50969-75 PubMed
  5. ↑ 5.0 5.1 5.2 5.3 De Lay, NR & Cronan, JE (2006) Gene-specific random mutagenesis of Escherichia coli in vivo: isolation of temperature-sensitive mutations in the acyl carrier protein of fatty acid synthesis. J. Bacteriol. 188 287-96 PubMed
  6. ↑ 6.00 6.01 6.02 6.03 6.04 6.05 6.06 6.07 6.08 6.09 6.10 6.11 6.12 6.13 6.14 6.15 6.16 6.17 6.18 6.19 6.20 6.21 6.22 6.23 6.24 6.25 6.26 6.27 6.28 6.29 6.30 6.31 6.32 6.33 Butland, G et al. (2005) Interaction network containing conserved and essential protein complexes in Escherichia coli. Nature 433 531-7 PubMed
  7. ↑ 7.00 7.01 7.02 7.03 7.04 7.05 7.06 7.07 7.08 7.09 7.10 7.11 7.12 7.13 7.14 7.15 7.16 7.17 7.18 7.19 Hu, P et al. (2009) Global functional atlas of Escherichia coli encompassing previously uncharacterized proteins. PLoS Biol. 7 e96 PubMed
  8. ↑ Finn, RD et al. (2010) The Pfam protein families database. Nucleic Acids Res. 38 D211-22 PubMed

Categories

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