accC:Gene Product(s)

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Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

AccC

Synonyms

acetyl-CoA carboxylase, biotin carboxylase subunit[1], B3256[2][1], AccC[2][1] , ECK3243, fabG, JW3224, b3256

Product description

AccC[2][3];

Component of biotin carboxylase[2][3]; acetyl CoA carboxylase[2][3]

Acetyl-CoA carboxylase, biotin carboxylase (BC) subunit[4]

EC number (for enzymes)
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Notes

Function

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<protect> Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000166

nucleotide binding

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0547

F

Seeded from EcoCyc (v14.0)

complete

GO:0003824

catalytic activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR005479

F

Seeded from EcoCyc (v14.0)

complete

GO:0003824

catalytic activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR005481

F

Seeded from EcoCyc (v14.0)

complete

GO:0003824

catalytic activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR011761

F

Seeded from EcoCyc (v14.0)

complete

GO:0003824

catalytic activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR013816

F

Seeded from EcoCyc (v14.0)

complete

GO:0003824

catalytic activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR013817

F

Seeded from EcoCyc (v14.0)

complete

GO:0003824

catalytic activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR016185

F

Seeded from EcoCyc (v14.0)

complete

GO:0003989

acetyl-CoA carboxylase activity

GOA:spec
GO_REF:0000003

IEA: Inferred from Electronic Annotation

EC:6.4.1.2

F

Seeded from EcoCyc (v14.0)

complete

GO:0004075

biotin carboxylase activity

GOA:spec
GO_REF:0000003

IEA: Inferred from Electronic Annotation

EC:6.3.4.14

F

Seeded from EcoCyc (v14.0)

complete

GO:0005524

ATP binding

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR005479

F

Seeded from EcoCyc (v14.0)

complete

GO:0005524

ATP binding

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR011761

F

Seeded from EcoCyc (v14.0)

complete

GO:0005524

ATP binding

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR011764

F

Seeded from EcoCyc (v14.0)

complete

GO:0045717

negative regulation of fatty acid biosynthetic process

PMID:17056747[5]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0005524

ATP binding

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR013816

F

Seeded from EcoCyc (v14.0)

complete

GO:0005524

ATP binding

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR013817

F

Seeded from EcoCyc (v14.0)

complete

GO:0005524

ATP binding

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR016185

F

Seeded from EcoCyc (v14.0)

complete

GO:0005524

ATP binding

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0067

F

Seeded from EcoCyc (v14.0)

complete

GO:0006633

fatty acid biosynthetic process

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0275

P

Seeded from EcoCyc (v14.0)

complete

GO:0006633

fatty acid biosynthetic process

PMID:10893421[6]

IMP: Inferred from Mutant Phenotype

P

Seeded from EcoCyc (v14.0)

complete

GO:0009374

biotin binding

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR011764

F

Seeded from EcoCyc (v14.0)

complete

GO:0016874

ligase activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR004549

F

Seeded from EcoCyc (v14.0)

complete

GO:0016874

ligase activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR005482

F

Seeded from EcoCyc (v14.0)

complete

GO:0016874

ligase activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR011764

F

Seeded from EcoCyc (v14.0)

complete

GO:0016874

ligase activity

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0436

F

Seeded from EcoCyc (v14.0)

complete

GO:0004075

biotin carboxylase activity

PMID:10893421[6]

IDA: Inferred from Direct Assay

F

complete

GO:0006633

fatty acid biosynthetic process

PMID:10893421[6]

IGI: Inferred from Genetic Interaction

EcoliWiki:accA EcoliWiki:accB EcoliWiki:accD


P

complete

GO:0005737

cytoplasm

PMID:10893421[6]

IC: Inferred by Curator

GO:0004075


C

complete

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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type Partner Notes References Evidence

Protein

Subunits of biotin carboxylase

could be indirect

Protein

accB

PMID:15690043[7]

Experiment(s):EBI-882643, EBI-890206

Protein

dnaK

PMID:15690043[7]

Experiment(s):EBI-882643

Protein

dnaN

PMID:15690043[7]

Experiment(s):EBI-882643

Protein

rplC

PMID:15690043[7]

Experiment(s):EBI-882643

Protein

nadE

PMID:16606699[8]

Experiment(s):EBI-1145313

Protein

yiiQ

PMID:16606699[8]

Experiment(s):EBI-1145313

Protein

greA

PMID:16606699[8]

Experiment(s):EBI-1145313

Protein

yraN

PMID:16606699[8]

Experiment(s):EBI-1145313

Protein

yiiS

PMID:16606699[8]

Experiment(s):EBI-1145313

Protein

accA

PMID:15690043[7]

Experiment(s):EBI-890206

Protein

accD

PMID:15690043[7]

Experiment(s):EBI-890206

Protein

cysM

PMID:15690043[7]

Experiment(s):EBI-890206

Protein

yhdY

PMID:15690043[7]

Experiment(s):EBI-890206

Protein

accA

PMID:19402753[9]

LCMS(ID Probability):99.0

Protein

cysM

PMID:19402753[9]

LCMS(ID Probability):99.6

Protein

accD

PMID:19402753[9]

LCMS(ID Probability):99.0

Protein

accB

PMID:19402753[9]

LCMS(ID Probability):99.6 MALDI(Z-score):17.053160

Protein

yhdY

PMID:19402753[9]

LCMS(ID Probability):99.0

Protein

Subunits of acetyl CoA carboxylase

could be indirect


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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment Description Evidence Reference/Source Notes
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Notes

Structure and Physical Properties

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<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence

at EcoCyc 

MLDKIVIANR GEIALRILRA CKELGIKTVA VHSSADRDLK HVLLADETVC IGPAPSVKSY
LNIPAIISAA EITGAVAIHP GYGFLSENAN FAEQVERSGF IFIGPKAETI RLMGDKVSAI
AAMKKAGVPC VPGSDGPLGD DMDKNRAIAK RIGYPVIIKA SGGGGGRGMR VVRGDAELAQ
SISMTRAEAK AAFSNDMVYM EKYLENPRHV EIQVLADGQG NAIYLAERDC SMQRRHQKVV
EEAPAPGITP ELRRYIGERC AKACVDIGYR GAGTFEFLFE NGEFYFIEMN TRIQVEHPVT
EMITGVDLIK EQLRIAAGQP LSIKQEEVHV RGHAVECRIN AEDPNTFLPS PGKITRFHAP
GGFGVRWESH IYAGYTVPPY YDSMIGKLIC YGENRDVAIA RMKNALQELI IDGIKTNVDL
QIRIMNDENF QHGGTNIHYL EKKLGLQEK
Length

449

Mol. Wt

49.321 kDa

pI

7.1 (calculated)

Extinction coefficient

27,850 - 28,850 (calc based on 15 Y, 1 W, and 8 C residues)

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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type Residues Description Notes References

Domain

336..441

PF02785 Biotin carboxylase C-terminal domain

PMID:19920124[10]

Domain

1..110

PF00289 Carbamoyl-phosphate synthase L chain, N-terminal domain

PMID:19920124[10]

Domain

115..324

PF02786 Carbamoyl-phosphate synthase L chain, ATP binding domain

PMID:19920124[10]

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Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=accC taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

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Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type Source Notes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

NCBI (Protein) (EcoliWiki Page)

GI:16131144

Escherichia coli str. K-12 substr. MG1655

NCBI (Protein) (EcoliWiki Page)

GeneID:947761

Escherichia coli str. K-12 substr. MG1655

ASAP

ASAP:ABE-0010677

Escherichia coli str. K-12 substr. MG1655

UniProt (EcoliWiki Page)

UniProtKB/Swiss-Prot:P24182

Escherichia coli str. K-12 substr. MG1655

EcoCyc

EcoCyc:EG10276

Escherichia coli str. K-12 substr. MG1655

EcoGene

EcoGene:EG10276

Escherichia coli str. K-12 substr. MG1655

NCBI (Gene) (EcoliWiki Page)

GeneID:947761

Escherichia coli str. K-12 substr. MG1655

RegulonDB

RegulonDB:ECK120000270

Escherichia coli str. K-12 substr. MG1655

EchoBASE

EchoBASE:EB0272

Escherichia coli str. K-12 substr. MG1655

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Notes

Links

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References

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See Help:References for how to manage references in EcoliWiki.

  1. ↑ 1.0 1.1 1.2 1.3 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 2.4 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ 3.0 3.1 3.2 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  5. ↑ Abdel-Hamid, AM & Cronan, JE (2007) Coordinate expression of the acetyl coenzyme A carboxylase genes, accB and accC, is necessary for normal regulation of biotin synthesis in Escherichia coli. J. Bacteriol. 189 369-76 PubMed
  6. ↑ 6.0 6.1 6.2 6.3 Davis, MS et al. (2000) Overproduction of acetyl-CoA carboxylase activity increases the rate of fatty acid biosynthesis in Escherichia coli. J. Biol. Chem. 275 28593-8 PubMed
  7. ↑ 7.0 7.1 7.2 7.3 7.4 7.5 7.6 7.7 Butland, G et al. (2005) Interaction network containing conserved and essential protein complexes in Escherichia coli. Nature 433 531-7 PubMed
  8. ↑ 8.0 8.1 8.2 8.3 8.4 Arifuzzaman, M et al. (2006) Large-scale identification of protein-protein interaction of Escherichia coli K-12. Genome Res. 16 686-91 PubMed
  9. ↑ 9.0 9.1 9.2 9.3 9.4 Hu, P et al. (2009) Global functional atlas of Escherichia coli encompassing previously uncharacterized proteins. PLoS Biol. 7 e96 PubMed
  10. ↑ 10.0 10.1 10.2 Finn, RD et al. (2010) The Pfam protein families database. Nucleic Acids Res. 38 D211-22 PubMed

Categories

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