aaeB:Gene Product(s)

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Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

AaeB

Synonyms

p-hydroxybenzoic acid efflux system component[1], B3240[2][1], AaeB[2][1], YhcP[2][1] , ECK3229, JW3209, yhcP, b3240

Product description

AaeAB Hydroxylated, Aromatic Carboxylic Acid Efflux Transport System Protein B[2][3];

Component of AaeAB Hydroxylated, Aromatic Carboxylic Acid Efflux Transport System[3]

AaeAB p-hydroxybenzoic acid efflux pump PET component; efflux protein family[4]

EC number (for enzymes)


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Notes

Function

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<protect> Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0006810

transport

PMID:15489430[5]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0005886

plasma membrane

GOA:hamap
GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_01545

C

Seeded from EcoCyc (v14.0)

complete

GO:0046942

carboxylic acid transport

PMID:15489430[5]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0005886

plasma membrane

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0997

C

Seeded from EcoCyc (v14.0)

complete

GO:0042221

response to chemical stimulus

PMID:15489430[5]

IGI: Inferred from Genetic Interaction

EcoliWiki:aaeA

P

complete

GO:0005886

plasma membrane

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-1003

C

Seeded from EcoCyc (v14.0)

complete

GO:0006810

transport

GOA:hamap
GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_01545

P

Seeded from EcoCyc (v14.0)

complete

GO:0006810

transport

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0813

P

Seeded from EcoCyc (v14.0)

complete

GO:0016020

membrane

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0472

C

Seeded from EcoCyc (v14.0)

complete

GO:0016021

integral to membrane

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0812

C

Seeded from EcoCyc (v14.0)

complete

GO:0016021

integral to membrane

GO_REF:0000023

IEA: Inferred from Electronic Annotation

SP_SL:SL-9909

C

Seeded from EcoCyc (v14.0)

complete

GO:0042221

response to chemical stimulus

PMID:15489430[5]

IGI: Inferred from Genetic Interaction

P

Seeded from EcoCyc (v14.0)

Missing: with/from

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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type Partner Notes References Evidence

Protein

Subunits of AaeAB Hydroxylated, Aromatic Carboxylic Acid Efflux Transport System

could be indirect


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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment Description Evidence Reference/Source Notes

plasma membrane

C-terminus localized in the cytoplasm with 10 predicted transmembrane domains

Daley et al. (2005) [6]


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Notes

Structure and Physical Properties

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<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence

at EcoCyc 

MGIFSIANQH IRFAVKLATA IVLALFVGFH FQLETPRWAV LTAAIVAAGT AFAAGGEPYS
GAIRYRGFLR IIGTFIGCIA GLVIIIAMIR APLLMILVCC IWAGFCTWIS SLVRIENSYA
WGLAGYTALI IVITIQPEPL LTPQFAVERC SEIVIGIVCA IMADLLFSPR SIKQEVDREL
ESLLVAQYQL MQLCIKHGDG EVVDKAWGDL VRRTTALQGM RSNLNMESSR WARANRRLKA
INTLSLTLIT QSCETYLIQN TRPELITDTF REFFDTPVET AQDVHKQLKR LRRVIAWTGE
RETPVTIYSW VAAATRYQLL KRGVISNTKI NATEEEILQG EPEVKVESAE RHHAMVNFWR
TTLSCILGTL FWLWTGWTSG SGAMVMIAVV TSLAMRLPNP RMVAIDFIYG TLAALPLGLL
YFLVIIPNTQ QSMLLLCISL AVLGFFLGIE VQKRRLGSMG ALASTINIIV LDNPMTFHFS
QFLDSALGQI VGCVLAFTVI LLVRDKSRDR TGRVLLNQFV SAAVSAMTTN VARRKENHLP
ALYQQLFLLM NKFPGDLPKF RLALTMIIAH QRLRDAPIPV NEDLSAFHRQ MRRTADHVIS
ARSDDKRRRY FGQLLEELEI YQEKLRIWQA PPQVTEPVNR LAGMLHKYQH ALTDS
Length

655

Mol. Wt

73.593 kDa

pI

9.6 (calculated)

Extinction coefficient

92,360 - 93,735 (calc based on 14 Y, 13 W, and 11 C residues)

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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type Residues Description Notes References

Domain

10..655

PF04632 Fusaric acid resistance protein family

PMID:19920124[7]

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<motif_map/>

tmhmm.php?gene=aaeB&show=pic&.jpg
Click the image to view raw output from TMHMM.

Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=aaeB taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

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Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type Source Notes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

NCBI (Protein) (EcoliWiki Page)

GI:16131130

Escherichia coli str. K-12 substr. MG1655

NCBI (Protein) (EcoliWiki Page)

GeneID:947747

Escherichia coli str. K-12 substr. MG1655

ASAP

ASAP:ABE-0010629

Escherichia coli str. K-12 substr. MG1655

UniProt (EcoliWiki Page)

UniProtKB/Swiss-Prot:P46481

Escherichia coli str. K-12 substr. MG1655

EcoCyc

EcoCyc:G7685

Escherichia coli str. K-12 substr. MG1655

EcoGene

EcoGene:EG12822

Escherichia coli str. K-12 substr. MG1655

NCBI (Gene) (EcoliWiki Page)

GeneID:947747

Escherichia coli str. K-12 substr. MG1655

RegulonDB

RegulonDB:ECK120004232

Escherichia coli str. K-12 substr. MG1655

EchoBASE

EchoBASE:EB2673

Escherichia coli str. K-12 substr. MG1655

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Notes

Links

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References

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See Help:References for how to manage references in EcoliWiki.

  1. ↑ 1.0 1.1 1.2 1.3 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ 3.0 3.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  5. ↑ 5.0 5.1 5.2 5.3 Van Dyk, TK et al. (2004) Characterization of the Escherichia coli AaeAB efflux pump: a metabolic relief valve? J. Bacteriol. 186 7196-204 PubMed
  6. ↑ Daley, DO et al. (2005) Global topology analysis of the Escherichia coli inner membrane proteome. Science 308 1321-3 PubMed
  7. ↑ Finn, RD et al. (2010) The Pfam protein families database. Nucleic Acids Res. 38 D211-22 PubMed

Categories

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