fabF:Gene Product(s)

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Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

FabF

Synonyms

3-oxoacyl-[acyl-carrier-protein] synthase II[1], B1095[2][1], Vtr[2][1], Cvc[2][1], VtrB[2][1], FabJ[2][1], FabF[2][1]

Product description

FabF[2][3];

Component of 3-oxoacyl-ACP synthase II[2]

beta-Ketoacyl-ACP synthase II; KAS II; homodimeric[4]

EC number (for enzymes)
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Notes

Function

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Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference(s) Evidence Code with/from Aspect Notes Status
GO:0016740

transferase activity

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0808

F

Seeded from EcoCyc [5]

complete

GO:0009058

biosynthetic process

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000794

P

Seeded from EcoCyc [5]

complete

GO:0008610

lipid biosynthetic process

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0444

P

Seeded from EcoCyc [5]

complete

GO:0008415

acyltransferase activity

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0012

F

Seeded from EcoCyc [5]

complete

GO:0006633

fatty acid biosynthetic process

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0275

P

Seeded from EcoCyc 12.5 [6]

complete

GO:0004315

3-oxoacyl-(acyl-carrier-protein) synthase activity

GO_REF:0000003

IEA: Inferred from Electronic Annotation

EC:2.3.1.41

F

Seeded from EcoCyc 12.5 [6]

complete

GO:0003824

catalytic activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000794

F

Seeded from EcoCyc 12.5 [6]

complete

GO:0005515

protein binding

PMID:15690043[7]

IPI: Inferred from Physical Interaction

UniProtKB:P0A6Y8

F

Seeded from EcoCyc [5]

complete

GO:0005737

cytoplasm

C

Seeded from EcoCyc 11.1[3].

required fields missing

GO:0005829

cytosol

PMID:16858726[8]

IDA: Inferred from Direct Assay

C

Seeded from EcoCyc [5]

complete

GO:0008152

metabolic process

GO_REF:0000002
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR016038
InterPro:IPR016039

P

Seeded from EcoCyc [5]

complete

GO:0016747

transferase activity, transferring acyl groups other than amino-acyl groups

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR017568

F

Seeded from EcoCyc [5]

complete

GO:0033817

beta-ketoacyl-acyl-carrier-protein synthase II activity

GO_REF:0000003

IEA: Inferred from Electronic Annotation

EC:2.3.1.179

F

Seeded from EcoCyc [5]

complete

GO:0003824

catalytic activity

GO_REF:0000002
GO_REF:0000002
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000794
InterPro:IPR016038
InterPro:IPR016039

F

Seeded from EcoCyc

complete

GO:0005515

protein binding

PMID:15690043[7]

IPI: Inferred from Physical Interaction

UniProtKB:P0A6Y8

F

Seeded from EcoCyc

complete

GO:0005829

cytosol

PMID:16858726[8]

IDA: Inferred from Direct Assay

C

Seeded from EcoCyc

complete

GO:0006633

fatty acid biosynthetic process

GO_REF:0000002
GO_REF:0000004

IEA: Inferred from Electronic Annotation

InterPro:IPR017568
SP_KW:KW-0275

P

Seeded from EcoCyc

complete

GO:0008152

metabolic process

GO_REF:0000002
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR016038
InterPro:IPR016039

P

Seeded from EcoCyc

complete

GO:0008415

acyltransferase activity

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0012

F

Seeded from EcoCyc

complete

GO:0008610

lipid biosynthetic process

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0444

P

Seeded from EcoCyc

complete

GO:0009058

biosynthetic process

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000794

P

Seeded from EcoCyc

complete

GO:0016740

transferase activity

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0808

F

Seeded from EcoCyc

complete

GO:0016747

transferase activity, transferring acyl groups other than amino-acyl groups

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR017568

F

Seeded from EcoCyc

complete

GO:0033817

beta-ketoacyl-acyl-carrier-protein synthase II activity

GO_REF:0000003

IEA: Inferred from Electronic Annotation

EC:2.3.1.179

F

Seeded from EcoCyc

complete

GO:0006654

phosphatidic acid biosynthetic process

P

Seeded from EcoCyc 11.1[3].

required fields missing

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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type Partner Notes References Evidence

Protein

Subunits of 3-oxoacyl-ACP synthase II

could be indirect

Protein

dnaK

PMID:15690043[7]

Experiment(s):EBI-887268, EBI-893240

Protein

dcd

PMID:16606699[9]

Experiment(s):EBI-1138841

Protein

napG

PMID:16606699[9]

Experiment(s):EBI-1138841

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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment Description Evidence Notes
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Notes

Structure and Physical Properties

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Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Sequence

at EcoCyc

MSKRRVVVTG LGMLSPVGNT VESTWKALLA GQSGISLIDH FDTSAYATKF AGLVKDFNCE
DIISRKEQRK MDAFIQYGIV AGVQAMQDSG LEITEENATR IGAAIGSGIG GLGLIEENHT
SLMNGGPRKI SPFFVPSTIV NMVAGHLTIM YGLRGPSISI ATACTSGVHN IGHAARIIAY
GDADVMVAGG AEKASTPLGV GGFGAARALS TRNDNPQAAS RPWDKERDGF VLGDGAGMLV
LEEYEHAKKR GAKIYAELVG FGMSSDAYHM TSPPENGAGA ALAMANALRD AGIEASQIGY
VNAHGTSTPA GDKAEAQAVK TIFGEAASRV LVSSTKSMTG HLLGAAGAVE SIYSILALRD
QAVPPTINLD NPDEGCDLDF VPHEARQVSG MEYTLCNSFG FGGTNGSLIF KKI
Length

413

Mol. Wt

43.046 kDa

pI

6.0 (calculated)

Extinction coefficient

25,900 - 26,400 (calc based on 10 Y, 2 W, and 4 C residues)

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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type Residues Description Notes
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<motif_map/>

Structure See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure>fabF 562</beststructure>

Models

View models at:

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Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type Source Notes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

EcoCyc (EcoliWiki Page)

EcoCyc:3-OXOACYL-ACP-SYNTHII-MONOMER

UniProt (EcoliWiki Page)

UniProt:P0AAI5

PFAM (EcoliWiki Page)

PFAM:PF00109

RefSeq (EcoliWiki Page)

RefSeq:NP_415613

PDB (EcoliWiki Page)

PDB:1KAS


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Notes

Links

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Name URL Comments
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References

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See Help:References for how to manage references in EcoliWiki.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ 3.0 3.1 3.2 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  5. ↑ 5.0 5.1 5.2 5.3 5.4 5.5 5.6 5.7 5.8 EcoCyc (release 13.0; 2009) Keseler, IM et al. (2009) Nucleic Acids Res. 37(Database issue):D464-70
  6. ↑ 6.0 6.1 6.2 EcoCyc (release 12.5; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  7. ↑ 7.0 7.1 7.2 Butland, G et al. (2005) Interaction network containing conserved and essential protein complexes in Escherichia coli. Nature 433 531-7 PubMed
  8. ↑ 8.0 8.1 Lasserre, JP et al. (2006) A complexomic study of Escherichia coli using two-dimensional blue native/SDS polyacrylamide gel electrophoresis. Electrophoresis 27 3306-21 PubMed
  9. ↑ 9.0 9.1 Arifuzzaman, M et al. (2006) Large-scale identification of protein-protein interaction of Escherichia coli K-12. Genome Res. 16 686-91 PubMed

Categories

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