aqpZ:Gene Product(s)

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Quickview   Gene   Gene Product(s)   Expression   Evolution   On One Page    
Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

AqpZ

Synonyms

aquaporin[1], B0875[2][1], BniP[2][1], AqpZ[2][1]

Product description

AqpZ - water MIP channel[2][3]

Aquaporin Z, bacterial glycerol and water channel; RpoS regulon[4]

EC number (for enzymes)


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Notes

Function

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Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference(s) Evidence Code with/from Aspect Notes Status
GO:0015250

water channel activity

GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_01146

F

Seeded from EcoCyc 12.5 [5]

complete

GO:0016021

integral to membrane

GO_REF:0000002
GO_REF:0000004

IEA: Inferred from Electronic Annotation

InterPro:IPR012269
SP_KW:KW-0812

C

Seeded from EcoCyc [6]

complete

GO:0016020

membrane

GO_REF:0000002
GO_REF:0000004
GO_REF:0000004

IEA: Inferred from Electronic Annotation

InterPro:IPR000425
SP_KW:KW-0397
SP_KW:KW-0472

C

Seeded from EcoCyc 12.5 [5]

complete

GO:0006833

water transport

PMID:10400575[7]

IMP: Inferred from Mutant Phenotype

P

Seeded from EcoCyc [6]

complete

GO:0006970

response to osmotic stress

PMID:10400575[7]

IMP: Inferred from Mutant Phenotype

P

Seeded from EcoCyc [6]

complete

GO:0009992

cellular water homeostasis

PMID:9520416[8]

IMP: Inferred from Mutant Phenotype

P

Seeded from EcoCyc [6]

complete

GO:0015250

water channel activity

PMID:10400575[7]

IMP: Inferred from Mutant Phenotype

F

Seeded from EcoCyc 12.5 [5]

complete

GO:0005215

transporter activity

GO_REF:0000002
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000425
InterPro:IPR012269

F

Seeded from EcoCyc [6]

complete

GO:0005886

plasma membrane

GO_REF:0000020
GO_REF:0000004
GO_REF:0000004
GO_REF:0000023

IEA: Inferred from Electronic Annotation

HAMAP:MF_01146
SP_KW:KW-0997
SP_KW:KW-1003
SP_SL:SL-0037

C

Seeded from EcoCyc [6]

complete

GO:0006810

transport

GO_REF:0000002
GO_REF:0000002
GO_REF:0000004

IEA: Inferred from Electronic Annotation

InterPro:IPR000425
InterPro:IPR012269
SP_KW:KW-0813

P

Seeded from EcoCyc [6]

complete

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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type Partner Notes References Evidence
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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment Description Evidence Notes

plasma membrane

C-terminus localized in the cytoplasm with 6 predicted transmembrane domains

Daley et al. (2005) [9]

plasma membrane

From EcoCyc[3]

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Notes

Structure and Physical Properties

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Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Sequence

at EcoCyc 

MFRKLAAECF GTFWLVFGGC GSAVLAAGFP ELGIGFAGVA LAFGLTVLTM AFAVGHISGG
HFNPAVTIGL WAGGRFPAKE VVGYVIAQVV GGIVAAALLY LIASGKTGFD AAASGFASNG
YGEHSPGGYS MLSALVVELV LSAGFLLVIH GATDKFAPAG FAPIAIGLAL TLIHLISIPV
TNTSVNPARS TAVAIFQGGW ALEQLWFFWV VPIVGGIIGG LIYRTLLEKR D
Length

231

Mol. Wt

23.7 kDa (calc) [2]

pI
Extinction coefficient

34950 - 35200 (calc based on 5 Y, 5 W, and 2 C residues)

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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type Residues Description Notes

Domain

205 - 227

Predicted membrane-spanning helix.

TMD predicted by TMHMM[10]

Domain

156 - 178

Predicted membrane-spanning helix.

TMD predicted by TMHMM[10]

Domain

127 - 149

Predicted membrane-spanning helix.

TMD predicted by TMHMM[10]

Domain

81 - 103

Predicted membrane-spanning helix.

TMD predicted by TMHMM[10]

Domain

33 - 55

Predicted membrane-spanning helix.

TMD predicted by TMHMM[10]

Domain

7 - 29

Predicted membrane-spanning helix.

TMD predicted by TMHMM[10]

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tmhmm.php?gene=aqpZ&show=pic&.jpg
Click the image to view raw output from TMHMM.

Structure See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure>aqpZ 562</beststructure>

Models

View models at:

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Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type Source Notes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

EcoCyc (EcoliWiki Page)

EcoCyc:AQPZ-MONOMER

UniProt (EcoliWiki Page)

UniProt:P60844

PFAM (EcoliWiki Page)

PFAM:PF00230

RefSeq (EcoliWiki Page)

RefSeq:NP_415396

ModBase (EcoliWiki Page)

ModBase:P60844

PDB (EcoliWiki Page)

PDB:1RC2


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Notes

Links

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Name URL Comments
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References

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  1. ↑ 1.0 1.1 1.2 1.3 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 2.4 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ 3.0 3.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  5. ↑ 5.0 5.1 5.2 EcoCyc (release 12.5; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  6. ↑ 6.0 6.1 6.2 6.3 6.4 6.5 6.6 EcoCyc (release 13.0; 2009) Keseler, IM et al. (2009) Nucleic Acids Res. 37(Database issue):D464-70
  7. ↑ 7.0 7.1 7.2 Delamarche, C et al. (1999) Visualization of AqpZ-mediated water permeability in Escherichia coli by cryoelectron microscopy. J. Bacteriol. 181 4193-7 PubMed
  8. ↑ Calamita, G et al. (1998) Regulation of the Escherichia coli water channel gene aqpZ. Proc. Natl. Acad. Sci. U.S.A. 95 3627-31 PubMed
  9. ↑ Daley, DO et al. (2005) Global topology analysis of the Escherichia coli inner membrane proteome. Science 308 1321-3 PubMed
  10. ↑ 10.0 10.1 10.2 10.3 10.4 10.5 Krogh, A et al. (2001) Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes. J. Mol. Biol. 305 567-80 PubMed


Categories

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