sucA:Gene Product(s)

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Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

SucA

Synonyms

2-oxoglutarate decarboxylase, thiamin-requiring[1]

Product description


2-oxoglutarate dehydrogenase, E1 component; yields succinyl-CoA and CO(2)[2]

EC number (for enzymes)
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Notes

Function

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Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference(s) Evidence Code with/from Aspect Notes Status
GO:0030976

thiamin pyrophosphate binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR011603

F

Seeded from EcoCyc 12.5 [3]

complete

GO:0016624

oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001017

F

Seeded from EcoCyc 12.5 [3]

complete

GO:0008152

metabolic process

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001017

P

Seeded from EcoCyc [4]

complete

GO:0006096

glycolysis

GO_REF:0000002
GO_REF:0000004

IEA: Inferred from Electronic Annotation

InterPro:IPR011603
SP_KW:KW-0324

P

Seeded from EcoCyc [4]

complete

GO:0004591

oxoglutarate dehydrogenase (succinyl-transferring) activity

GO_REF:0000002
GO_REF:0000003

IEA: Inferred from Electronic Annotation

InterPro:IPR011603
EC:1.2.4.2

F

Seeded from EcoCyc [4]

complete

GO:0005737

cytoplasm

C

Seeded from Riley et al 2006 [1].

required fields missing

GO:0005829

cytosol

PMID:16858726[5]

IDA: Inferred from Direct Assay

C

Seeded from EcoCyc [4]

complete

GO:0006099

tricarboxylic acid cycle

P

Seeded from Riley et al 2006 [1].

required field missing

GO:0016491

oxidoreductase activity

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0560

F

Seeded from EcoCyc [4]

complete

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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type Partner Notes References Evidence

Protein

hflK

PMID:15690043[6]

Experiment(s):EBI-880717

Protein

lipA

PMID:15690043[6]

Experiment(s):EBI-880717

Protein

lpdA

PMID:15690043[6]

Experiment(s):EBI-880717, EBI-886788

Protein

sucB

PMID:15690043[6]

Experiment(s):EBI-880717, EBI-880739, EBI-886788

Protein

groL

PMID:16606699[7]

Experiment(s):EBI-1137802

Protein

dnaE

PMID:16606699[7]

Experiment(s):EBI-1137802

Protein

oxc

PMID:16606699[7]

Experiment(s):EBI-1137802

Protein

rplC

PMID:15690043[6]

Experiment(s):EBI-886788

Small Molecule

TTTPP

selectively inhibits pyruvate or 2-oxoglutarate dehydrogenase (El).


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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment Description Evidence Notes
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Notes

Structure and Physical Properties

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Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Sequence

at EcoCyc 

 




Mol. Wt






pI






Extinction coefficient











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Domains/Motifs/Modification Sites
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Type
Residues
Description
Notes




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Structure
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Structures



<beststructure>sucA
562</beststructure>






Models



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Notes


Gene Product Resources


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 See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.







Resource type
Source
Notes/Reference




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Notes


Accessions in Other Databases


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See Help:Gene_accessions for help with entering information into the Gene Accessions table.







Database
Accession
Notes




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Notes


Links


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Name
URL
Comments




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References


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  1. ↑ 1.0 1.1 1.2 1.3 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)  

    2. 

  2. ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.   

    3. 

  3. ↑ 3.0 3.1 EcoCyc (release 12.5; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7  

    4. 

  4. ↑ 4.0 4.1 4.2 4.3 4.4 EcoCyc (release 13.0; 2009) Keseler, IM et al. (2009) Nucleic Acids Res. 37(Database issue):D464-70  

    5. 

  5. ↑ Lasserre, JP et al. (2006) A complexomic study of Escherichia coli using two-dimensional blue native/SDS polyacrylamide gel electrophoresis. Electrophoresis 27 3306-21  PubMed 

    6. 

  6. ↑ 6.0 6.1 6.2 6.3 6.4 Butland, G et al. (2005) Interaction network containing conserved and essential protein complexes in Escherichia coli. Nature 433 531-7  PubMed 

    7. 

  7. ↑ 7.0 7.1 7.2 Arifuzzaman, M et al. (2006) Large-scale identification of protein-protein interaction of Escherichia coli K-12. Genome Res. 16 686-91  PubMed 

    8. 








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