mtn:Gene Product(s)

Standard name	Pfs
Synonyms	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase^[1], B0159^[2]^[1], Mtn^[2]^[1], YadA^[2]^[1], Pfs^[2]^[1]
Product description	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase^[2]^[3]; Component of 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase^[3] 5'-Methylthioadenosine nucleosidase; S-adenosylhomocysteine and 5'-deoxyadenosine are also substrates^[4]
EC number (for enzymes)	3.2.2.9^[1] 3.2.2.16^[1]
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Notes

Function

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Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier	GO ID	GO term name	Reference(s)	Evidence Code	with/from	Aspect	Notes	Status
	GO:0005737	cytoplasm	PMID:16858726^[5]	IDA: Inferred from Direct Assay		C	Seeded from EcoCyc ^[6]	complete
	GO:0003824	catalytic activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000845	F	Seeded from EcoCyc ^[6]	complete
	GO:0008930	methylthioadenosine nucleosidase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR010049	F	Seeded from EcoCyc 12.5 ^[7]	complete
	GO:0009116	nucleoside metabolic process	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000845	P	Seeded from EcoCyc 12.5 ^[7]	complete
	GO:0009164	nucleoside catabolic process	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR010049	P	Seeded from EcoCyc 12.5 ^[7]	complete
	GO:0016787	hydrolase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0378	F	Seeded from EcoCyc 12.5 ^[7]	complete
	GO:0019509	methionine salvage	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR010049	P	Seeded from EcoCyc 12.5 ^[7]	complete
	GO:0015949	nucleobase, nucleoside and nucleotide interconversion				P	Seeded from EcoCyc 11.1^[3].	required fields missing
	GO:0008782	adenosylhomocysteine nucleosidase activity	GO_REF:0000002 GO_REF:0000003	IEA: Inferred from Electronic Annotation	InterPro:IPR010049 EC:3.2.2.9	F	Seeded from EcoCyc ^[6]	complete
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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type	Partner	Notes
Protein	Subunits of 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase	could be indirect
Protein	Subunits of 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase	could be indirect
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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment	Description	Evidence	Notes
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Notes

Structure and Physical Properties

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Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Sequence	at EcoCyc MKIGIIGAME EEVTLLRDKI ENRQTISLGG CEIYTGQLNG TEVALLKSGI GKVAAALGAT LLLEHCKPDV IINTGSAGGL APTLKVGDIV VSDEARYHDA DVTAFGYEYG QLPGCPAGFK ADDKLIAAAE ACIAELNLNA VRGLIVSGDA FINGSVGLAK IRHNFPQAIA VEMEATAIAH VCHNFNVPFV VVRAISDVAD QQSHLSFDEF LAVAAKQSSL MVESLVQKLA HG	at EcoCyc MKIGIIGAME EEVTLLRDKI ENRQTISLGG CEIYTGQLNG TEVALLKSGI GKVAAALGAT LLLEHCKPDV IINTGSAGGL APTLKVGDIV VSDEARYHDA DVTAFGYEYG QLPGCPAGFK ADDKLIAAAE ACIAELNLNA VRGLIVSGDA FINGSVGLAK IRHNFPQAIA VEMEATAIAH VCHNFNVPFV VVRAISDVAD QQSHLSFDEF LAVAAKQSSL MVESLVQKLA HG
Mol. Wt	24.35 kDa (calc) ^[2]	24.35 kDa (calc) ^[2]
pI
Extinction coefficient	5960 - 6585 (calc based on 4 Y, 0 W, and 5 C residues)	5960 - 6585 (calc based on 4 Y, 0 W, and 5 C residues)
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Domains/Motifs/Modification Sites See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type	Residues	Description	Notes
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Structure See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

Models

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Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type	Source	Notes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
PDB (EcoliWiki Page)	PDB:1Z5P
EcoCyc (EcoliWiki Page)	EcoCyc:EG11090-MONOMER
SwissModel (EcoliWiki Page)	SwissModel:P0AF12
UniProt (EcoliWiki Page)	UniProt:P0AF12
PFAM (EcoliWiki Page)	PFAM:PF01048
RefSeq (EcoliWiki Page)	RefSeq:NP_414701
ModBase (EcoliWiki Page)	ModBase:P0AF12
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Notes

Links

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Name	URL	Comments
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References

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↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
↑ ^3.0 ^3.1 ^3.2 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
↑ Lasserre, JP et al. (2006) A complexomic study of Escherichia coli using two-dimensional blue native/SDS polyacrylamide gel electrophoresis. Electrophoresis 27 3306-21 PubMed
↑ ^6.0 ^6.1 ^6.2 EcoCyc (release 13.0; 2009) Keseler, IM et al. (2009) Nucleic Acids Res. 37(Database issue):D464-70
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 EcoCyc (release 12.5; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7

mtn:Gene Product(s)

Nomenclature

Notes

Function

Notes

Localization

Notes

Structure and Physical Properties

Notes

Gene Product Resources

Notes

Accessions in Other Databases

Notes

Links

References

Categories

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mtn:Gene Product(s)

Nomenclature

Notes

Function

Notes

Localization

Notes

Structure and Physical Properties

Notes

Gene Product Resources

Notes

Accessions in Other Databases

Notes

Links

References

Categories

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