nei:Gene Product(s)

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Gene

Gene Product(s)

Expression

Evolution

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Nomenclature

Function

Interactions

Localization

Sequence

Structure

Resources

Accessions

Links

References

Suggestions

Nomenclature

Standard name	Nei product
Synonyms	endonuclease VIII product, 5-formyluracil/5-hydroxymethyluracil DNA glycosylase product, B0714 product, Nei product
Product description	endonuclease VIII
EC number (for enzymes)	3.2.-.-
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Function

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Gene Ontology

Qualifier	GO ID	GO term name	Reference(s)	Evidence Code	with/from	Aspect	Notes	Status
	GO:0000703	oxidized pyrimidine base lesion DNA N-glycosylase activity	GO_REF:0000020	IEA: Inferred from Electronic Annotation	HAMAP:MF_01253	F	Seeded from EcoCyc 12.5	complete
	GO:0003676	nucleic acid binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR010979	F	Seeded from EcoCyc 12.5	complete
	GO:0003677	DNA binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR015886	F	Seeded from EcoCyc 12.5	complete
	GO:0003677	DNA binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0238	F	Seeded from EcoCyc 12.5	complete
	GO:0003684	damaged DNA binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR012319	F	Seeded from EcoCyc 12.5	complete
	GO:0003824	catalytic activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR015886	F	Seeded from EcoCyc 12.5	complete
	GO:0003824	catalytic activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0511	F	Seeded from EcoCyc 12.5	complete
	GO:0003906	DNA-(apurinic or apyrimidinic site) lyase activity	GO_REF:0000020	IEA: Inferred from Electronic Annotation	HAMAP:MF_01253	F	Seeded from EcoCyc 12.5	complete
	GO:0003906	DNA-(apurinic or apyrimidinic site) lyase activity	GO_REF:0000003	IEA: Inferred from Electronic Annotation	EC:4.2.99.18	F	Seeded from EcoCyc 12.5	complete
	GO:0006281	DNA repair	GO_REF:0000020	IEA: Inferred from Electronic Annotation	HAMAP:MF_01253	P	Seeded from EcoCyc 12.5	complete
	GO:0006281	DNA repair	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000214	P	Seeded from EcoCyc 12.5	complete
	GO:0006281	DNA repair	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0234	P	Seeded from EcoCyc 12.5	complete
	GO:0006284	base-excision repair	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR012319	P	Seeded from EcoCyc 12.5	complete
	GO:0006289	nucleotide-excision repair	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR015886	P	Seeded from EcoCyc 12.5	complete
	GO:0006974	response to DNA damage stimulus	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0227	P	Seeded from EcoCyc 12.5	complete
	GO:0005737	cytoplasm				C	Seeded from EcoCyc 11.1.	required fields missing
	GO:0008152	metabolic process	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0326	P	Seeded from EcoCyc 12.5	complete
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Interactions

Partner Type	Partner	Notes
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Localization

Compartment	Description	Evidence	Notes
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Structure and Physical Properties

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Physical Properties

Sequence	at EcoCyc MPEGPEIRRA ADNLEAAIKG KPLTDVWFAF PQLKPYQSQL IGQHVTHVET RGKALLTHFS NDLTLYSHNQ LYGVWRVVDT GEEPQTTRVL RVKLQTADKT ILLYSASDIE MLTPEQLTTH PFLQRVGPDV LDPNLTPEVV KERLLSPRFR NRQFAGLLLD QAFLAGLGNY LRVEILWQVG LTGNHKAKDL NAAQLDALAH ALLEIPRFSY ATRGQVDENK HHGALFRFKV FHRDGEPCER CGSIIEKTTL SSRPFYWCPG CQH
Mol. Wt	29.85 kDa (calc)
pI
Extinction coefficient	32430 - 32930 (calc based on 7 Y, 4 W, and 4 C residues)
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Domains/Motifs/Modification Sites

Type	Residues	Description	Notes
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Structure

Structure Type	Organism	Accession	Residues covered	Notes
X-RAY DIFFRACTION	synthetic construct	1K3X Crystal structure of a trapped reaction intermediate of the DNA repair enzyme Endonuclease VIII with Brominated-DNA
X-RAY DIFFRACTION	synthetic construct	1K3W Crystal structure of a trapped reaction intermediate of the DNA Repair Enzyme Endonuclease VIII with DNA
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Gene Product Resources

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Resource type	Source	Notes/Reference
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Accessions in Other Databases

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Database	Accession	Notes
EcoCyc (EcoliWiki Page)	EcoCyc:G6383-MONOMER
UniProt (EcoliWiki Page)	UniProt:P50465
PFAM (EcoliWiki Page)	PFAM:PF01149
RefSeq (EcoliWiki Page)	RefSeq:NP_415242
ModBase (EcoliWiki Page)	ModBase:P50465
PDB (EcoliWiki Page)	PDB:1K3W
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Links

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Name	URL	Comments
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References

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Categories

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