msbA:Gene Product(s)

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Nomenclature Function Interactions Localization Sequence Structure Resources Accessions Links References Suggestions

Nomenclature

Standard name

MsbA product

Synonyms

fused lipid transporter subunits of ABC superfamily: membrane component product[1], ATP-binding component product[1], B0914 product[2][1], MsbA product[2][1]

Product description

ATP-binding transport protein[2][3]

EC number (for enzymes)
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Notes

Function

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Gene Ontology

Qualifier GO ID GO term name Reference(s) Evidence Code with/from Aspect Notes Status
GO:0016021

integral_to_membrane

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR011917

C

Seeded from EcoCyc 12.5 [4]

GO:0016021

integral_to_membrane

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0812

C

Seeded from EcoCyc 12.5 [4]

GO:0016787

hydrolase_activity

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0378

F

Seeded from EcoCyc 12.5 [4]

GO:0016887

ATPase_activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR003439

F

Seeded from EcoCyc 12.5 [4]

GO:0016887

ATPase_activity

PMID:12119303[5]

IDA: Inferred from Direct Assay

F

Seeded from EcoCyc 12.5 [4]

GO:0006869

lipid_transport

PMID:11278265[6]

IMP: Inferred from Mutant Phenotype

P

Seeded from EcoCyc 12.5 [4]

GO:0009276

cell_wall_(sensu_Proteobacteria)

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR011917

C

Seeded from EcoCyc 12.5 [4]

GO:0015437

lipopolysaccharide-transporting_ATPase_activity

PMID:12119303[5]

IDA: Inferred from Direct Assay

F

Seeded from EcoCyc 12.5 [4]

GO:0016020

membrane

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0397

C

Seeded from EcoCyc 12.5 [4]

GO:0016020

membrane

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0472

C

Seeded from EcoCyc 12.5 [4]

GO:0016021

integral_to_membrane

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001140

C

Seeded from EcoCyc 12.5 [4]

GO:0016021

integral_to_membrane

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR011527

C

Seeded from EcoCyc 12.5 [4]

GO:0006869

lipid_transport

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0445

P

Seeded from EcoCyc 12.5 [4]

GO:0005524

ATP_binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR003439

F

Seeded from EcoCyc 12.5 [4]

GO:0005524

ATP_binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR011527

F

Seeded from EcoCyc 12.5 [4]

GO:0005524

ATP_binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR011917

F

Seeded from EcoCyc 12.5 [4]

GO:0005524

ATP_binding

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0067

F

Seeded from EcoCyc 12.5 [4]

GO:0005524

ATP_binding

PMID:8809774[7]

IDA: Inferred from Direct Assay

F

Seeded from EcoCyc 12.5 [4]

GO:0005624

membrane_fraction

PMID:16858726[8]

IDA: Inferred from Direct Assay

C

Seeded from EcoCyc 12.5 [4]

GO:0006810

transport

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001140

P

Seeded from EcoCyc 12.5 [4]

GO:0006810

transport

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR011527

P

Seeded from EcoCyc 12.5 [4]

GO:0006810

transport

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0813

P

Seeded from EcoCyc 12.5 [4]

GO:0006869

lipid_transport

GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_01703

P

Seeded from EcoCyc 12.5 [4]

GO:0006869

lipid_transport

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR011917

P

Seeded from EcoCyc 12.5 [4]

GO:0000166

nucleotide_binding

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0547

F

Seeded from EcoCyc 12.5 [4]

GO:0005319

lipid_transporter_activity

GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_01703

F

Seeded from EcoCyc 12.5 [4]

GO:0005319

lipid_transporter_activity

PMID:11278265[6]

IMP: Inferred from Mutant Phenotype

F

Seeded from EcoCyc 12.5 [4]

GO:0005524

ATP_binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001140

F

Seeded from EcoCyc 12.5 [4]

GO:0000166

nucleotide_binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR003593

F

Seeded from EcoCyc 12.5 [4]

GO:0017111

nucleoside-triphosphatase_activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR003593

F

Seeded from EcoCyc 12.5 [4]


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Interactions

Partner Type Partner Notes
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Notes

Localization

Compartment Description Evidence Notes
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Notes

Structure and Physical Properties

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Physical Properties

Sequence

at EcoCyc 

MHNDKDLSTW QTFRRLWPTI APFKAGLIVA GVALILNAAS DTFMLSLLKP LLDDGFGKTD
RSVLVWMPLV VIGLMILRGI TSYVSSYCIS WVSGKVVMTM RRRLFGHMMG MPVSFFDKQS
TGTLLSRITY DSEQVASSSS GALITVVREG ASIIGLFIMM FYYSWQLSII LIVLAPIVSI
AIRVVSKRFR NISKNMQNTM GQVTTSAEQM LKGHKEVLIF GGQEVETKRF DKVSNRMRLQ
GMKMVSASSI SDPIIQLIAS LALAFVLYAA SFPSVMDSLT AGTITVVFSS MIALMRPLKS
LTNVNAQFQR GMAACQTLFT ILDSEQEKDE GKRVIERATG DVEFRNVTFT YPGRDVPALR
NINLKIPAGK TVALVGRSGS GKSTIASLIT RFYDIDEGEI LMDGHDLREY TLASLRNQVA
LVSQNVHLFN DTVANNIAYA RTEQYSREQI EEAARMAYAM DFINKMDNGL DTVIGENGVL
LSGGQRQRIA IARALLRDSP ILILDEATSA LDTESERAIQ AALDELQKNR TSLVIAHRLS
TIEKADEIVV VEDGVIVERG THNDLLEHRG VYAQLHKMQF GQ
Mol. Wt

64.46 kDa (calc) [2]

pI
Extinction coefficient

46870 - 47120 (calc based on 13 Y, 5 W, and 2 C residues)

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Domains/Motifs/Modification Sites

Type Residues Description Notes
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Structure

Structure Type Organism Accession Residues covered Notes
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Notes

Gene Product Resources

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Resource type Source Notes/Reference
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Notes

Accessions in Other Databases

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Database Accession Notes

EcoCyc (EcoliWiki Page)

EcoCyc:EG10613-MONOMER

UniProt (EcoliWiki Page)

UniProt:P60752

PFAM (EcoliWiki Page)

PFAM:PF00664

RefSeq (EcoliWiki Page)

RefSeq:NP_415434

ModBase (EcoliWiki Page)

ModBase:P60752

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Notes

Links

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Name URL Comments
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References

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See Help:References for how to manage references in EcoliWiki.

  1. ↑ 1.0 1.1 1.2 1.3 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ 4.00 4.01 4.02 4.03 4.04 4.05 4.06 4.07 4.08 4.09 4.10 4.11 4.12 4.13 4.14 4.15 4.16 4.17 4.18 4.19 4.20 4.21 4.22 4.23 4.24 4.25 4.26 4.27 4.28 4.29 EcoCyc (release 12.5; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  5. ↑ 5.0 5.1 Doerrler, WT & Raetz, CR (2002) ATPase activity of the MsbA lipid flippase of Escherichia coli. J. Biol. Chem. 277 36697-705 PubMed
  6. ↑ 6.0 6.1 Doerrler, WT et al. (2001) An Escherichia coli mutant defective in lipid export. J. Biol. Chem. 276 11461-4 PubMed
  7. ↑ Polissi, A & Georgopoulos, C (1996) Mutational analysis and properties of the msbA gene of Escherichia coli, coding for an essential ABC family transporter. Mol. Microbiol. 20 1221-33 PubMed
  8. ↑ Lasserre, JP et al. (2006) A complexomic study of Escherichia coli using two-dimensional blue native/SDS polyacrylamide gel electrophoresis. Electrophoresis 27 3306-21 PubMed


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