glyA:Gene Product(s)

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Quickview   Gene   Gene Product(s)   Expression   Evolution   On One Page    
Nomenclature Function Interactions Localization Sequence Structure Resources Accessions Links References Suggestions

Nomenclature

Standard name

GlyA product

Synonyms

serine hydroxymethyltransferase product[1], B2551 product[2][1], GlyA product[2][1]

Product description

GlyA[2][3];

Component of ; glycine hydroxymethyltransferase[2][3]

EC number (for enzymes)
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Notes

Function

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Gene Ontology

Qualifier GO ID GO term name Reference(s) Evidence Code with/from Aspect Notes Status
GO:0005737

cytoplasm

C

Seeded from EcoCyc 11.1[3].

required fields missing

GO:0009063

amino acid catabolic process

P

Seeded from EcoCyc 11.1[3].

required fields missing

GO:0006545

glycine biosynthetic process

P

Seeded from EcoCyc 11.1[3].

required fields missing

GO:0046656

folic acid biosynthetic process

P

Seeded from EcoCyc 11.1[3].

required fields missing

GO:0009257

10-formyltetrahydrofolate biosynthetic process

P

Seeded from EcoCyc 11.1[3].

required fields missing

GO:0004372

glycine hydroxymethyltransferase activity

PMID:6190704[4]

IMP: Inferred from Mutant Phenotype

F

complete

GO:0004372

glycine hydroxymethyltransferase activity

PMID:3891721[5]

IDA: Inferred from Direct Assay

F

complete

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Interactions

Partner Type Partner Notes

Protein

Subunits of glycine hydroxymethyltransferase

could be indirect

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Notes

Localization

Compartment Description Evidence Notes
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Notes

Structure and Physical Properties

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Physical Properties

Sequence

at EcoCyc 

MLKREMNIAD YDAELWQAME QEKVRQEEHI ELIASENYTS PRVMQAQGSQ LTNKYAEGYP
GKRYYGGCEY VDIVEQLAID RAKELFGADY ANVQPHSGSQ ANFAVYTALL EPGDTVLGMN
LAHGGHLTHG SPVNFSGKLY NIVPYGIDAT GHIDYADLEK QAKEHKPKMI IGGFSAYSGV
VDWAKMREIA DSIGAYLFVD MAHVAGLVAA GVYPNPVPHA HVVTTTTHKT LAGPRGGLIL
AKGGSEELYK KLNSAVFPGG QGGPLMHVIA GKAVALKEAM EPEFKTYQQQ VAKNAKAMVE
VFLERGYKVV SGGTDNHLFL VDLVDKNLTG KEADAALGRA NITVNKNSVP NDPKSPFVTS
GIRVGTPAIT RRGFKEAEAK ELAGWMCDVL DSINDEAVIE RIKGKVLDIC ARYPVYA
Mol. Wt

45.32 kDa (calc) [2]

pI

6.41[2]

Extinction coefficient

46300 - 46675 (calc based on 20 Y, 3 W, and 3 C residues)

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Domains/Motifs/Modification Sites

Type Residues Description Notes
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Structure

Structure Type Organism Accession Residues covered Notes

X-RAY DIFFRACTION

Escherichia coli

1EQB X-RAY CRYSTAL STRUCTURE AT 2.7 ANGSTROMS RESOLUTION OF TERNARY COMPLEX BETWEEN THE Y65F MUTANT OF E-COLI SERINE HYDROXYMETHYLTRANSFERASE, GLYCINE AND 5-FORMYL TETRAHYDROFOLATE

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Notes

Gene Product Resources

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Resource type Source Notes/Reference
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Notes

Accessions in Other Databases

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Database Accession Notes

EcoCyc (EcoliWiki Page)

EcoCyc:GLYOHMETRANS-MONOMER

UniProt (EcoliWiki Page)

UniProt:P0A825

PFAM (EcoliWiki Page)

PFAM:PF00464

RefSeq (EcoliWiki Page)

RefSeq:NP_417046

ModBase (EcoliWiki Page)

ModBase:P0A825

PDB (EcoliWiki Page)

PDB:1EQB

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Notes

Links

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Name URL Comments
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References

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  1. ↑ 1.0 1.1 1.2 1.3 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 2.4 2.5 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ 3.0 3.1 3.2 3.3 3.4 3.5 3.6 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ Plamann, MD & Stauffer, GV (1983) Characterization of the Escherichia coli gene for serine hydroxymethyltransferase. Gene 22 9-18 PubMed
  5. ↑ Schirch, V et al. (1985) Serine hydroxymethyltransferase from Escherichia coli: purification and properties. J. Bacteriol. 163 1-7 PubMed


Categories

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