lrp:Gene Product(s)

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Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

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Standard name

Lrp

Synonyms

DNA-binding transcriptional dual regulator, leucine-binding[1], B0889[2][1], LstR[2][1], Mbf[2][1], OppI[2][1], RblA[2][1], Lss[2][1], Lrs[2][1], Ihb[2][1], Lrp[2][1], LivR[2][1], regulator for leucine (or lrp) regulon and high-affinity branched-chain amino acid transport system.[2][1]

Product description

Lrp transcriptional dual regulator[2][3]

Global regulatory protein, Leu responsive; regulator of high-affinity branched-chain amino acid transport system; octameric or hexadecameric functional state[4]

EC number (for enzymes)


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Notes

Function

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Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference(s) Evidence Code with/from Aspect Notes Status
GO:0043565

sequence-specific DNA binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000485

F

Seeded from EcoCyc [5]

complete

GO:0006355

regulation of transcription, DNA-dependent

PMID:12374860[6]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0005622

intracellular

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000485

C

Seeded from EcoCyc [5]

complete

GO:0003700

transcription factor activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000485

F

Seeded from EcoCyc [5]

complete

GO:0003677

DNA binding

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0238

F

Seeded from EcoCyc [5]

complete

GO:0005515

protein binding

PMID:16606699[7]

IPI: Inferred from Physical Interaction

UniProtKB:P0A744

F

Seeded from EcoCyc [5]

complete

GO:0009099

valine biosynthetic process

P

Seeded from EcoCyc 11.1[3].

required fields missing

GO:0009098

leucine biosynthetic process

P

Seeded from EcoCyc 11.1[3].

required fields missing

GO:0016564

transcription repressor activity

F

Seeded from EcoCyc 11.1[3].

required fields missing

GO:0005737

cytoplasm

C

Seeded from EcoCyc 11.1[3].

required fields missing

GO:0016563

transcription activator activity

F

Seeded from EcoCyc 11.1[3].

required fields missing

GO:0043201

response to leucine

PMID:1346534[8] PMID:12054800[9]

IDA: Inferred from Direct Assay

P

complete

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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type Partner Notes References Evidence

Protein

trxB

PMID:16606699[7]

Experiment(s):EBI-1138286

Protein

nadE

PMID:16606699[7]

Experiment(s):EBI-1138286
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Notes

Localization

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Compartment Description Evidence Source Notes
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Notes

Structure and Physical Properties

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Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Sequence

at EcoCyc 

MVDSKKRPGK DLDRIDRNIL NELQKDGRIS NVELSKRVGL SPTPCLERVR RLERQGFIQG
YTALLNPHYL DASLLVFVEI TLNRGAPDVF EQFNTAVQKL EEIQECHLVS GDFDYLLKTR
VPDMSAYRKL LGETLLRLPG VNDTRTYVVM EEVKQSNRLV IKTR
Length

164

Mol. Wt

18.886 kDa

pI

9.1 (calculated)

Extinction coefficient

7,450 - 7,700 (calc based on 5 Y, W, and 2 C residues)

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Domains/Motifs/Modification Sites

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Type Residues Description Notes References

Initiator Methionine

1

Removed

UniProt:P0ACJ0


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<motif_map/>

Structure
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Structures

<beststructure> gene=lrp taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type Source Notes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

EcoCyc (EcoliWiki Page)

EcoCyc:PD00353

UniProt (EcoliWiki Page)

UniProt:P0ACJ0

RefSeq (EcoliWiki Page)

RefSeq:NP_415409


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Notes

Links

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References

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See Help:References for how to manage references in EcoliWiki.

  1. ↑ 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 1.10 1.11 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.00 2.01 2.02 2.03 2.04 2.05 2.06 2.07 2.08 2.09 2.10 2.11 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ 3.0 3.1 3.2 3.3 3.4 3.5 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  5. ↑ 5.0 5.1 5.2 5.3 5.4 EcoCyc (release 13.0; 2009) Keseler, IM et al. (2009) Nucleic Acids Res. 37(Database issue):D464-70
  6. ↑ Tani, TH et al. (2002) Adaptation to famine: a family of stationary-phase genes revealed by microarray analysis. Proc. Natl. Acad. Sci. U.S.A. 99 13471-6 PubMed
  7. ↑ 7.0 7.1 7.2 Arifuzzaman, M et al. (2006) Large-scale identification of protein-protein interaction of Escherichia coli K-12. Genome Res. 16 686-91 PubMed
  8. ↑ Ernsting, BR et al. (1992) Characterization of the regulon controlled by the leucine-responsive regulatory protein in Escherichia coli. J. Bacteriol. 174 1109-18 PubMed
  9. ↑ Chen, S & Calvo, JM (2002) Leucine-induced dissociation of Escherichia coli Lrp hexadecamers to octamers. J. Mol. Biol. 318 1031-42 PubMed

Categories

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