metN:Gene Product(s)

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Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

MetN

Synonyms

DL-methionine transporter subunit[1], ATP-binding component of ABC superfamily[1], B0199[2][1], MetD[2][1], MetN[2][1], Abc[2][1]

Product description

MetN[2][3];

Component of L- and D-methionine uptake ABC permease[2][3]

L,D-methionine transporter, ATP-binding protein; methionine sulfoximine sensitivity[4]

EC number (for enzymes)


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Notes

Function

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Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference(s) Evidence Code with/from Aspect Notes Status
GO:0005515

protein binding

PMID:15690043[5]

IPI: Inferred from Physical Interaction

UniProtKB:P0A6N1

F

Seeded from EcoCyc [6]

complete

GO:0000166

nucleotide binding

GO_REF:0000002
GO_REF:0000004

IEA: Inferred from Electronic Annotation

InterPro:IPR003593
SP_KW:KW-0547

F

Seeded from EcoCyc [6]

complete

GO:0005524

ATP binding

PMID:12169620[7]

IDA: Inferred from Direct Assay

F

Seeded from EcoCyc 12.5 [8]

complete

GO:0006810

transport

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0813

P

Seeded from EcoCyc [6]

complete

GO:0006865

amino acid transport

GO_REF:0000004
GO_REF:0000020

IEA: Inferred from Electronic Annotation

SP_KW:KW-0029
HAMAP:MF_01719

P

Seeded from EcoCyc 12.5 [8]

complete

GO:0009276

Gram-negative-bacterium-type cell wall

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR012692

C

Seeded from EcoCyc [6]

complete

GO:0015424

amino acid-transporting ATPase activity

GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_01719

F

Seeded from EcoCyc 12.5 [8]

complete

GO:0016020

membrane

GO_REF:0000004
GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0397
SP_KW:KW-0472

C

Seeded from EcoCyc 12.5 [8]

complete

GO:0016787

hydrolase activity

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0378

F

Seeded from EcoCyc [6]

complete

GO:0016887

ATPase activity

PMID:12169620[7]

IDA: Inferred from Direct Assay

F

Seeded from EcoCyc 12.5 [8]

complete

GO:0017111

nucleoside-triphosphatase activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR003593

F

Seeded from EcoCyc [6]

complete

GO:0048473

D-methionine transport

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR012692

P

Seeded from EcoCyc [6]

complete

GO:0048474

D-methionine transmembrane transporter activity

PMID:12169620[7]

IDA: Inferred from Direct Assay

F

Seeded from EcoCyc [6]

complete

GO:0005737

cytoplasm

C

Seeded from EcoCyc 11.1[3].

required fields missing

GO:0005886

plasma membrane

GO_REF:0000004
GO_REF:0000004
GO_REF:0000023

IEA: Inferred from Electronic Annotation

SP_KW:KW-0997
SP_KW:KW-1003
SP_SL:SL-0037

C

Seeded from EcoCyc [6]

complete

GO:0015821

methionine transport

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR017908

P

Seeded from EcoCyc [6]

complete

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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type Partner Notes References Evidence

Protein

Subunits of L- and D-methionine uptake ABC permease

could be indirect

Protein

tufA

PMID:15690043[5]

Experiment(s):EBI-879029

Protein

mntR

PMID:15690043[5]

Experiment(s):EBI-882305

Protein

gyrB

PMID:15690043[5]

Experiment(s):EBI-882305

Protein

hycG

PMID:15690043[5]

Experiment(s):EBI-882305

Protein

ilvD

PMID:15690043[5]

Experiment(s):EBI-882305

Protein

perR

PMID:15690043[5]

Experiment(s):EBI-882305

Protein

wcaC

PMID:15690043[5]

Experiment(s):EBI-882305

Protein

yfeA

PMID:15690043[5]

Experiment(s):EBI-882305

Protein

yhjB

PMID:15690043[5]

Experiment(s):EBI-882305

Protein

yjhC

PMID:15690043[5]

Experiment(s):EBI-882305

Protein

dnaK

PMID:16606699[9]

Experiment(s):EBI-1135927

Protein

yehH

PMID:16606699[9]

Experiment(s):EBI-1135927

Protein

truA

PMID:16606699[9]

Experiment(s):EBI-1135927
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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment Description Evidence Source Notes

cytoplasm

From EcoCyc[3]


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Notes

Structure and Physical Properties

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Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Sequence

at EcoCyc 

MIKLSNITKV FHQGTRTIQA LNNVSLHVPA GQIYGVIGAS GAGKSTLIRC VNLLERPTEG
SVLVDGQELT TLSESELTKA RRQIGMIFQH FNLLSSRTVF GNVALPLELD NTPKDEVKRR
VTELLSLVGL GDKHDSYPSN LSGGQKQRVA IARALASNPK VLLCDEATSA LDPATTRSIL
ELLKDINRRL GLTILLITHE MDVVKRICDC VAVISNGELI EQDTVSEVFS HPKTPLAQKF
IQSTLHLDIP EDYQERLQAE PFTDCVPMLR LEFTGQSVDA PLLSETARRF NVNNNIISAQ
MDYAGGVKFG IMLTEMHGTQ QDTQAAIAWL QEHHVKVEVL GYV
Length

343

Mol. Wt

37.788 kDa

pI

6.4 (calculated)

Extinction coefficient

12,950 - 13,575 (calc based on 5 Y, 1 W, and 5 C residues)

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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type Residues Description Notes References
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<motif_map/>

Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=metN taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type Source Notes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

EcoCyc (EcoliWiki Page)

EcoCyc:ABC-MONOMER

SwissModel (EcoliWiki Page)

SwissModel:P30750

UniProt (EcoliWiki Page)

UniProt:P30750

PFAM (EcoliWiki Page)

PFAM:PF00005

RefSeq (EcoliWiki Page)

RefSeq:NP_414741


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Notes

Links

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References

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See Help:References for how to manage references in EcoliWiki.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 2.4 2.5 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ 3.0 3.1 3.2 3.3 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  5. ↑ 5.00 5.01 5.02 5.03 5.04 5.05 5.06 5.07 5.08 5.09 5.10 Butland, G et al. (2005) Interaction network containing conserved and essential protein complexes in Escherichia coli. Nature 433 531-7 PubMed
  6. ↑ 6.00 6.01 6.02 6.03 6.04 6.05 6.06 6.07 6.08 6.09 EcoCyc (release 13.0; 2009) Keseler, IM et al. (2009) Nucleic Acids Res. 37(Database issue):D464-70
  7. ↑ 7.0 7.1 7.2 Gál, J et al. (2002) The metD D-methionine transporter locus of Escherichia coli is an ABC transporter gene cluster. J. Bacteriol. 184 4930-2 PubMed
  8. ↑ 8.0 8.1 8.2 8.3 8.4 EcoCyc (release 12.5; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  9. ↑ 9.0 9.1 9.2 Arifuzzaman, M et al. (2006) Large-scale identification of protein-protein interaction of Escherichia coli K-12. Genome Res. 16 686-91 PubMed

Categories

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