msbA:Gene Product(s)

From EcoliWiki
Revision as of 23:06, 18 June 2010 by 127.0.0.1 (talk)
Jump to navigation Jump to search

{{#css:Suppresslinks.css}}<css>h1 .editsection { display:none;} h2 .editsection { display:none;}</css>

Quickview   Gene   Gene Product(s)   Expression   Evolution   On One Page    
Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

MsbA fused lipid transporter subunits of ABC superfamily: membrane component[1], ATP-binding component[1], B0914[2][1], MsbA[2][1] ATP-binding transport protein[2][3]

Lipid exporter to the outer membrane; exports LPS, phospholipids, and lipid A; drug export and resistance; ABC transporter flippase; biogenesis of outer membrane; lipid-activated ATPase[4]

Synonyms
Product description
EC number (for enzymes)


edit table


Notes

Function

[back to top]


Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference(s) Evidence Code with/from Aspect Notes Status
GO:0005319

lipid transporter activity GOA:hamap
GO_REF:0000020 IEA: Inferred from Electronic Annotation HAMAP:MF_01703 F Seeded from EcoCyc (v14.0)

GO:0005524

ATP binding GOA:interpro
GO_REF:0000002 IEA: Inferred from Electronic Annotation InterPro:IPR001140 F Seeded from EcoCyc (v14.0)

GO:0005524

ATP binding GOA:interpro
GO_REF:0000002 IEA: Inferred from Electronic Annotation InterPro:IPR003439 F Seeded from EcoCyc (v14.0)

GO:0005524

ATP binding GOA:interpro
GO_REF:0000002 IEA: Inferred from Electronic Annotation InterPro:IPR011527 F Seeded from EcoCyc (v14.0)

GO:0005524

ATP binding GOA:interpro
GO_REF:0000002 IEA: Inferred from Electronic Annotation InterPro:IPR011917 F Seeded from EcoCyc (v14.0)

GO:0005524

ATP binding GOA:interpro
GO_REF:0000002 IEA: Inferred from Electronic Annotation InterPro:IPR017871 F Seeded from EcoCyc (v14.0)

GO:0005524

ATP binding GOA:spkw
SP_KW:GO_REF:0000004 IEA: Inferred from Electronic Annotation SP_KW:KW-0067 F Seeded from EcoCyc (v14.0)

GO:0005886

plasma membrane GOA:spkw
SP_KW:GO_REF:0000004 IEA: Inferred from Electronic Annotation SP_KW:KW-0997 C Seeded from EcoCyc (v14.0)

GO:0005886

plasma membrane GOA:spkw
SP_KW:GO_REF:0000004 IEA: Inferred from Electronic Annotation SP_KW:KW-1003 C Seeded from EcoCyc (v14.0)

GO:0006869

lipid transport GOA:hamap
GO_REF:0000020 IEA: Inferred from Electronic Annotation HAMAP:MF_01703 P Seeded from EcoCyc (v14.0)

GO:0006869

lipid transport GOA:interpro
GO_REF:0000002 IEA: Inferred from Electronic Annotation InterPro:IPR011917 P Seeded from EcoCyc (v14.0)

GO:0006869

lipid transport GOA:spkw
SP_KW:GO_REF:0000004 IEA: Inferred from Electronic Annotation SP_KW:KW-0445 P Seeded from EcoCyc (v14.0)

GO:0016020

membrane GOA:spkw
SP_KW:GO_REF:0000004 IEA: Inferred from Electronic Annotation SP_KW:KW-0472 C Seeded from EcoCyc (v14.0)

GO:0016020

membrane PMID:16858726[5] IDA: Inferred from Direct Assay

C

Seeded from EcoCyc (v14.0)

GO:0016021

integral to membrane GOA:interpro
GO_REF:0000002 IEA: Inferred from Electronic Annotation InterPro:IPR001140 C Seeded from EcoCyc (v14.0)

GO:0016021

integral to membrane GOA:interpro
GO_REF:0000002 IEA: Inferred from Electronic Annotation InterPro:IPR011527 C Seeded from EcoCyc (v14.0)

GO:0016021

integral to membrane GOA:interpro
GO_REF:0000002 IEA: Inferred from Electronic Annotation InterPro:IPR011917 C Seeded from EcoCyc (v14.0)

GO:0005515

protein binding PMID:18344567[6] IDA: Inferred from Direct Assay

C

complete

GO:0016021

integral to membrane GOA:spkw
SP_KW:GO_REF:0000004 IEA: Inferred from Electronic Annotation SP_KW:KW-0812 C Seeded from EcoCyc (v14.0)

GO:0034040

lipid-transporting ATPase activity PMID:18344567[6] IDA: Inferred from Direct Assay

F

complete

GO:0016021

integral to membrane GO_REF:0000023 IEA: Inferred from Electronic Annotation SP_SL:SL-9909 C Seeded from EcoCyc (v14.0)

GO:0008289

lipid binding PMID:18344567[6] IDA: Inferred from Direct Assay

F

complete

GO:0055085

transmembrane transport GOA:interpro
GO_REF:0000002 IEA: Inferred from Electronic Annotation InterPro:IPR001140 P Seeded from EcoCyc (v14.0)

GO:0008144

drug binding PMID:18344567[6] IDA: Inferred from Direct Assay

F

complete

GO:0055085

transmembrane transport GOA:interpro
GO_REF:0000002 IEA: Inferred from Electronic Annotation InterPro:IPR011527 P Seeded from EcoCyc (v14.0)


edit table

Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type Partner Notes References Evidence
edit table


Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment Description Evidence Source Notes

plasma membrane C-terminus localized in the cytoplasm with 6 predicted transmembrane domains Daley et al. (2005) [7]



edit table


Notes

Structure and Physical Properties

[back to top]


Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Sequence

at EcoCyc 

MHNDKDLSTW QTFRRLWPTI APFKAGLIVA GVALILNAAS DTFMLSLLKP LLDDGFGKTD
RSVLVWMPLV VIGLMILRGI TSYVSSYCIS WVSGKVVMTM RRRLFGHMMG MPVSFFDKQS
TGTLLSRITY DSEQVASSSS GALITVVREG ASIIGLFIMM FYYSWQLSII LIVLAPIVSI
AIRVVSKRFR NISKNMQNTM GQVTTSAEQM LKGHKEVLIF GGQEVETKRF DKVSNRMRLQ
GMKMVSASSI SDPIIQLIAS LALAFVLYAA SFPSVMDSLT AGTITVVFSS MIALMRPLKS
LTNVNAQFQR GMAACQTLFT ILDSEQEKDE GKRVIERATG DVEFRNVTFT YPGRDVPALR
NINLKIPAGK TVALVGRSGS GKSTIASLIT RFYDIDEGEI LMDGHDLREY TLASLRNQVA
LVSQNVHLFN DTVANNIAYA RTEQYSREQI EEAARMAYAM DFINKMDNGL DTVIGENGVL
LSGGQRQRIA IARALLRDSP ILILDEATSA LDTESERAIQ AALDELQKNR TSLVIAHRLS
TIEKADEIVV VEDGVIVERG THNDLLEHRG VYAQLHKMQF GQ

582 64.462 kDa 8.8 (calculated) 46,870 - 47,120 (calc based on 13 Y, 5 W, and 2 C residues)

Length
Mol. Wt
pI
Extinction coefficient


edit table


Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type Residues Description Notes References
edit table

<motif_map/>

tmhmm.php?gene=msbA&show=pic&.jpg
Click the image to view raw output from TMHMM.

Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=msbA taxon=562,83333 </beststructure> View models at:

Models


edit table

Structure figures

Notes

Gene Product Resources

[back to top]


See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type Source Notes/Reference
edit table


Notes

Accessions in Other Databases

[back to top]


See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

EcoCyc (EcoliWiki Page) EcoCyc:EG10613-MONOMER

UniProt (EcoliWiki Page) UniProt:P60752

PFAM (EcoliWiki Page) PFAM:PF00664

RefSeq (EcoliWiki Page) RefSeq:NP_415434


edit table


Notes

Links

[back to top]




References

[back to top]


See Help:References for how to manage references in EcoliWiki.

  1. ↑ 1.0 1.1 1.2 1.3 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  5. ↑ Lasserre, JP et al. (2006) A complexomic study of Escherichia coli using two-dimensional blue native/SDS polyacrylamide gel electrophoresis. Electrophoresis 27 3306-21 PubMed
  6. ↑ 6.0 6.1 6.2 6.3 Eckford, PD & Sharom, FJ (2008) Functional characterization of Escherichia coli MsbA: interaction with nucleotides and substrates. J. Biol. Chem. 283 12840-50 PubMed
  7. ↑ Daley, DO et al. (2005) Global topology analysis of the Escherichia coli inner membrane proteome. Science 308 1321-3 PubMed

Categories

[back to top]


Retrieved from "https://ecoliwiki.org/colipedia/index.php?title=msbA:Gene_Product(s)&oldid=1147694"