prpC:Gene Product(s): Difference between revisions

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<span id="Structure"></span><big>'''Structure'''</big>
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<span id='Structure'></span><big>'''Structure'''</big><br />
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==== Structure figures ====
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
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===Notes===
===Notes===


Revision as of 16:38, 23 July 2009

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Quickview   Gene   Gene Product(s)   Expression   Evolution   On One Page    
Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

PrpC

Synonyms

2-methylcitrate synthase[1], B0333[2][1], YahS[2][1], YzzD[2][1], PrpC[2][1]

Product description

G6198[2][3];

Component of methylcitrate synthase[3]

2-Methylcitrate synthase; propionate catabolism via 2-methlycitrate cycle, characterized primarily in Salmonella[4]

EC number (for enzymes)
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Notes

Function

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Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference(s) Evidence Code with/from Aspect Notes Status
GO:0050440

2-methylcitrate synthase activity

PMID:9325432[5]

IDA: Inferred from Direct Assay

F

Seeded from EcoCyc 12.5 [6]

complete

GO:0050440

2-methylcitrate synthase activity

GO_REF:0000003

IEA: Inferred from Electronic Annotation

EC:2.3.3.5

F

Seeded from EcoCyc 12.5 [6]

complete

GO:0046912

transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer

GO_REF:0000002
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR002020
InterPro:IPR011278

F

Seeded from EcoCyc 12.5 [6]

complete

GO:0016740

transferase activity

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0808

F

Seeded from EcoCyc [7]

complete

GO:0005737

cytoplasm

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR011278

C

Seeded from EcoCyc [7]

complete

GO:0019679

propionate metabolic process, methylcitrate cycle

PMID:9325432[5]

IDA: Inferred from Direct Assay

P

Seeded from EcoCyc [7]

complete

GO:0044262

cellular carbohydrate metabolic process

GO_REF:0000002
GO_REF:0000002
GO_REF:0000002
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR002020
InterPro:IPR011278
InterPro:IPR016141
InterPro:IPR016142

P

Seeded from EcoCyc [7]

complete

GO:0005737

cytoplasm

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR011278

C

Seeded from EcoCyc

complete

GO:0019679

propionate metabolic process, methylcitrate cycle

PMID:9325432[5]

IDA: Inferred from Direct Assay

P

Seeded from EcoCyc

complete

GO:0044262

cellular carbohydrate metabolic process

GO_REF:0000002
GO_REF:0000002
GO_REF:0000002
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR002020
InterPro:IPR011278
InterPro:IPR016141
InterPro:IPR016142

P

Seeded from EcoCyc

complete

GO:0046912

transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer

GO_REF:0000002
GO_REF:0000002
GO_REF:0000002
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR002020
InterPro:IPR011278
InterPro:IPR016141
InterPro:IPR016142

F

Seeded from EcoCyc

complete

GO:0050440

2-methylcitrate synthase activity

GO_REF:0000003
PMID:9325432[5]

IDA: Inferred from Direct Assay

EC:2.3.3.5

F

Seeded from EcoCyc

complete

GO:0016052

carbohydrate catabolic process

P

Seeded from EcoCyc 11.1[3].

required fields missing

GO:0019679

propionate metabolic process, methylcitrate cycle

PMID:9325432[5]

IDA: Inferred from Direct Assay

P

complete

GO:0050440

2-methylcitrate synthase activity

PMID:9325432[5]

IDA: Inferred from Direct Assay

F

complete

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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type Partner Notes References Evidence

Protein

Subunits of methylcitrate synthase

could be indirect

Protein

napC

PMID:16606699[8]

Experiment(s):EBI-1136274

Protein

nadE

PMID:16606699[8]

Experiment(s):EBI-1136274

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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment Description Evidence Notes
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Notes

Structure and Physical Properties

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Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Sequence

at EcoCyc 

MSDTTILQNS THVIKPKKSV ALSGVPAGNT ALCTVGKSGN DLHYRGYDIL DLAKHCEFEE
VAHLLIHGKL PTRDELAAYK TKLKALRGLP ANVRTVLEAL PAASHPMDVM RTGVSALGCT
LPEKEGHTVS GARDIADKLL ASLSSILLYW YHYSHNGERI QPETDDDSIG GHFLHLLHGE
KPSQSWEKAM HISLVLYAEH EFNASTFTSR VIAGTGSDMY SAIIGAIGAL RGPKHGGANE
VSLEIQQRYE TPDEAEADIR KRVENKEVVI GFGHPVYTIA DPRHQVIKRV AKQLSQEGGS
LKMYNIADRL ETVMWESKKM FPNLDWFSAV SYNMMGVPTE MFTPLFVIAR VTGWAAHIIE
QRQDNKIIRP SANYVGPEDR PFVALDKRQ
Length

389

Mol. Wt

43.102 kDa

pI

7.1 (calculated)

Extinction coefficient

46,870 - 47,245 (calc based on 13 Y, 5 W, and 3 C residues)

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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type Residues Description Notes
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<motif_map/>

Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure>prpC 562</beststructure>

Models

View models at:

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Structure figures

Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type Source Notes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

EcoCyc (EcoliWiki Page)

EcoCyc:G6198-MONOMER

UniProt (EcoliWiki Page)

UniProt:P31660

PFAM (EcoliWiki Page)

PFAM:PF00285

RefSeq (EcoliWiki Page)

RefSeq:NP_414867

ModBase (EcoliWiki Page)

ModBase:P31660


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Notes

Links

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Name URL Comments
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References

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See Help:References for how to manage references in EcoliWiki.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 2.4 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ 3.0 3.1 3.2 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  5. ↑ 5.0 5.1 5.2 5.3 5.4 5.5 Textor, S et al. (1997) Propionate oxidation in Escherichia coli: evidence for operation of a methylcitrate cycle in bacteria. Arch. Microbiol. 168 428-36 PubMed
  6. ↑ 6.0 6.1 6.2 EcoCyc (release 12.5; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  7. ↑ 7.0 7.1 7.2 7.3 EcoCyc (release 13.0; 2009) Keseler, IM et al. (2009) Nucleic Acids Res. 37(Database issue):D464-70
  8. ↑ 8.0 8.1 Arifuzzaman, M et al. (2006) Large-scale identification of protein-protein interaction of Escherichia coli K-12. Genome Res. 16 686-91 PubMed

Categories

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